Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Alexandra E. Conibear"'
Autor:
Alexandra E. Conibear, Eamonn Kelly
Publikováno v:
Mol Pharmacol
The field of biased agonism has grown substantially in recent years and the μ-opioid receptor has been one of the most intensively studied receptor targets for developing biased agonists. Yet, despite extensive research efforts, the development of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272bfffea7ac4b54c6dceeace6867c89
https://doi.org/10.1124/mol.119.115956
https://doi.org/10.1124/mol.119.115956
Autor:
Nina K Blum, Alexandra E. Conibear, Lawrence Toll, Christopher P Bailey, Sam Groom, Stefan Schulz, Andrea Kliewer, Yangmei Li, Robert J. Hill, Graeme Henderson, Stephen M. Husbands, Alexander Disney, Eamonn Kelly
Publikováno v:
Groom, S, Blum, N K, Conibear, A E, Disney, A, Hill, R, Husbands, S M, Li, Y, Toll, L, Kliewer, A, Schulz, S, Henderson, G, Kelly, E & Bailey, C P 2020, ' A novel G protein-biased agonist at the μ opioid receptor induces substantial receptor desensitization through G protein-coupled receptor kinase ', British Journal of Pharmacology . https://doi.org/10.1111/bph.15334
Background and purpose G protein-biased μ opioid receptor agonists have the potential to induce less receptor desensitisation and tolerance than balanced opioids. Here, we investigated if the cyclic endomorphin analogue Tyr-c[D-Lys-Phe-Tyr-Gly] (Com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc648062a7130f11bcbd573241c38c74
https://purehost.bath.ac.uk/ws/files/214871251/Groom_et_al_Accepted_version_inc_figures.pdf
https://purehost.bath.ac.uk/ws/files/214871251/Groom_et_al_Accepted_version_inc_figures.pdf
Autor:
Alexandra E, Conibear, Junaid, Asghar, Rob, Hill, Graeme, Henderson, Eva, Borbely, Valeria, Tekus, Zsuzsanna, Helyes, Josephine, Palandri, Chris, Bailey, Ingemar, Starke, Bengt, von Mentzer, David, Kendall, Eamonn, Kelly
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics
Agonists at the δ opioid receptor are known to be potent antihyperalgesics in chronic pain models and effective in models of anxiety and depression. However, some δ opioid agonists have proconvulsant properties while tolerance to the therapeutic ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0ca4495a6e2a0845669d1fa86960b59d
https://pubmed.ncbi.nlm.nih.gov/31594792
https://pubmed.ncbi.nlm.nih.gov/31594792
Autor:
Groom, Sam1,2 (AUTHOR), Blum, Nina K.3 (AUTHOR), Conibear, Alexandra E.2 (AUTHOR), Disney, Alexander1 (AUTHOR), Hill, Rob2,4 (AUTHOR), Husbands, Stephen M.1 (AUTHOR), Li, Yangmei5 (AUTHOR), Toll, Lawrence6 (AUTHOR), Kliewer, Andrea3 (AUTHOR), Schulz, Stefan3 (AUTHOR), Henderson, Graeme2 (AUTHOR), Kelly, Eamonn2 (AUTHOR), Bailey, Chris P.1 (AUTHOR) c.p.bailey@bath.ac.uk
Publikováno v:
British Journal of Pharmacology. Apr2023, Vol. 180 Issue 7, p943-957. 15p. 1 Black and White Photograph, 1 Chart, 5 Graphs.