Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Alexandra Diot"'
Autor:
Flora Nguyen Van Long, Audrey Lardy-Cleaud, Dimitri Carène, Caroline Rossoni, Frédéric Catez, Paul Rollet, Nathalie Pion, Déborah Monchiet, Agathe Dolbeau, Marjorie Martin, Valentin Simioni, Susan Bray, Doris Le Beherec, Fernanda Mosele, Ibrahim Bouakka, Amélie Colombe-Vermorel, Laetitia Odeyer, Alexandra Diot, Lee B. Jordan, Alastair M. Thompson, Françoise Jamen, Thierry Dubois, Sylvie Chabaud, Stefan Michiels, Isabelle Treilleux, Jean-Christophe Bourdon, David Pérol, Alain Puisieux, Fabrice André, Jean-Jacques Diaz, Virginie Marcel
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-12 (2022)
Abstract Background A current critical need remains in the identification of prognostic and predictive markers in early breast cancer. It appears that a distinctive trait of cancer cells is their addiction to hyperactivation of ribosome biogenesis. T
Externí odkaz:
https://doaj.org/article/fb1de5e1e47048e5883db9d402d40dd4
Autor:
Muyang, Li, Fredrick, Philantrope, Alexandra, Diot, Jean-Christophe, Bourdon, Patricia, Thompson
Publikováno v:
Cancers; Volume 14; Issue 13; Pages: 3255
SMG1, a phosphatidylinositol 3-kinase-related kinase (PIKK), essential in nonsense-mediated RNA decay (NMD), also regulates p53, including the alternative splicing of p53 isoforms reported to retain p53 functions. We confirm that SMG1 inhibition in M
Autor:
Gilles Gadea, Nikola Arsic, Kenneth Fernandes, Alexandra Diot, Sébastien M Joruiz, Samer Abdallah, Valerie Meuray, Stéphanie Vinot, Christelle Anguille, Judit Remenyi, Marie P Khoury, Philip R Quinlan, Colin A Purdie, Lee B Jordan, Frances V Fuller-Pace, Marion de Toledo, Maïlys Cren, Alastair M Thompson, Jean-Christophe Bourdon, Pierre Roux
Publikováno v:
eLife, Vol 5 (2016)
TP53 is conventionally thought to prevent cancer formation and progression to metastasis, while mutant TP53 has transforming activities. However, in the clinic, TP53 mutation status does not accurately predict cancer progression. Here we report, base
Externí odkaz:
https://doaj.org/article/f581c63f2c83491e9dc7660202f2310e
Autor:
Sun-Young Lee, Claire Robertson, Alexandra Diot, Valerie Meuray, Jean-Christophe Bourdon, Mina J. Bissell
Publikováno v:
Journal of cell science. 135(21)
Growing evidence indicates that p53 (encoded by TP53) has a crucial role in normal tissue development. The role of the canonical p53 (p53α) and its 12 isoforms in development and homeostasis of healthy tissue remains poorly understood. Here, we demo
Autor:
Flora Nguyen Van Long, Audrey Lardy-Cleaud, Dimitri Carène, Caroline Rossoni, Frédéric Catez, Paul Rollet, Nathalie Pion, Déborah Monchiet, Agathe Dolbeau, Marjorie Martin, Valentin Simioni, Susan Bray, Doris Le Beherec, Fernanda Mosele, Ibrahim Bouakka, Amélie Colombe-Vermorel, Laetitia Odeyer, Alexandra Diot, Lee B. Jordan, Alastair M. Thompson, Françoise Jamen, Thierry Dubois, Sylvie Chabaud, Stefan Michiels, Isabelle Treilleux, Jean-Christophe Bourdon, David Pérol, Alain Puisieux, Fabrice André, Jean-Jacques Diaz, Virginie Marcel
Publikováno v:
BMC Cancer
BMC Cancer, 2022, 22 (1), pp.526. ⟨10.1186/s12885-022-09552-x⟩
BMC Cancer, 2022, 22 (1), pp.526. ⟨10.1186/s12885-022-09552-x⟩
Background A current critical need remains in the identification of prognostic and predictive markers in early breast cancer. It appears that a distinctive trait of cancer cells is their addiction to hyperactivation of ribosome biogenesis. Thus, ribo
Autor:
Flora, Nguyen Van Long, Audrey, Lardy-Cleaud, Susan, Bray, Sylvie, Chabaud, Thierry, Dubois, Alexandra, Diot, Alastair M, Thompson, Jean-Christophe, Bourdon, David, Perol, Philippe, Bouvet, Jean-Jacques, Diaz, Virginie, Marcel
Publikováno v:
Cancers
Background: Nucleolin (NCL) is a multifunctional protein with oncogenic properties. Anti-NCL drugs show strong cytotoxic effects, including in triple-negative breast cancer (TNBC) models, and are currently being evaluated in phase II clinical trials.
Autor:
Frederik J. Hes, T. van Wezel, Stephanie A. Schubert, Dina Ruano, Alexandra Diot, D.Q.C.M. Barge-Schaapveld, Carli M. J. Tops, Jean-Christophe Bourdon, N F de Miranda, Sebastien M. Joruiz
Publikováno v:
ESMO Open. 3:A249-A250
Introduction Germline pathogenic variants in the canonical TP53 gene cause Li-Fraumeni, a severe cancer predisposition syndrome characterised by early onset of multiple tumours, particularly breast cancer, brain tumours, soft-tissue sarcomas, osteosa
Autor:
Frances V. Fuller-Pace, Samer Abdallah, Pierre Roux, Christelle Anguille, Marie P. Khoury, Alexandra Diot, Nikola Arsic, Valerie Meuray, Colin A. Purdie, Philip R. Quinlan, Judit Remenyi, St�phanie Vinot, Marion de Toledo, S�bastien M. Joruiz, Ma�lys Cren, Gilles Gadea, Lee B. Jordan, Kenneth Fernandes, Alastair M. Thompson, Jean-Christophe Bourdon
Publikováno v:
eLife
eLife, eLife Sciences Publication, 2016, 5, 〈10.7554/eLife.14734〉
eLife, Vol 5 (2016)
eLife, eLife Sciences Publication, 2016, 5, pp.e14734. ⟨10.7554/eLife.14734⟩
eLife, 2016, 5, pp.e14734. ⟨10.7554/eLife.14734⟩
eLife, eLife Sciences Publication, 2016, 5, 〈10.7554/eLife.14734〉
eLife, Vol 5 (2016)
eLife, eLife Sciences Publication, 2016, 5, pp.e14734. ⟨10.7554/eLife.14734⟩
eLife, 2016, 5, pp.e14734. ⟨10.7554/eLife.14734⟩
TP53 is conventionally thought to prevent cancer formation and progression to metastasis, while mutant TP53 has transforming activities. However, in the clinic, TP53 mutation status does not accurately predict cancer progression. Here we report, base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd6e5e3665203f26a5977193bbf1fdd8
http://hal.univ-reunion.fr/hal-01703040
http://hal.univ-reunion.fr/hal-01703040
Autor:
Sebastien M. Joruiz, Judit Remenyi, Alexandra Diot, Gilles Gadea, Valerie Meuray, Marie P. Khoury, Christelle Anguille, Stéphanie Vinot, Marion de Toledo, Frances V. Fuller-Pace, Philip R. Quinlan, Colin A. Purdie, Nikola Arsic, Kenneth Fernandes, Samer Abdallah, Alastair M. Thompson, Lee B. Jordan, Jean-Christophe Bourdon, Maïlys Cren, Pierre Roux
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b8de1f78025ccf44c1eb1f433992bc2
https://doi.org/10.7554/elife.14734.022
https://doi.org/10.7554/elife.14734.022
Autor:
Crissy Dudgeon, Jean-Christophe Bourdon, David P. Lane, Alexandra Diot, Calvina Kek, Kenneth Fernandes, Shin'ichi Saito, Albert J. Fornace, Ettore Appella, Oleg N. Demidov, Dmitry V. Bulavin
Publikováno v:
Cancer Research. 66:2928-2936
Activation of apoptosis is believed to be critical for the role of p53 as a tumor suppressor. Here, we report a new mouse strain carrying a human p53 transgene in the mouse p53-null background. Expression of human p53 in these mice was comparable wit