Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Alexandra D. Zaitsev"'
Autor:
Soumya S. Ray, Stephanie Kang, Scott A. Gerber, Min Liu, Alexandra D. Zaitsev, Gregory D. Cuny, Marcie A. Glicksman, Justin W. Jackson
Publikováno v:
Biochemistry. 50:9399-9408
Leucine-rich repeat kinase 2 (LRRK2), a large and complex protein that possesses two enzymatic properties, kinase and GTPase, is one of the major genetic factors in Parkinson's disease (PD). Here, we characterize the kinetic and catalytic mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::558f272facef4a0353acccad99cd9934
https://doi.org/10.1021/bi201173d
https://doi.org/10.1021/bi201173d
Autor:
Alexandra D. Zaitsev, Marcie A. Glicksman, Ross L. Stein, Brittany Dobson, Ken Auerbach, Zhenyu Yue, Min Liu, Kathleen Seyb, Shibu M. Poulose, Eli R. Schuman, Gregory D. Cuny
Publikováno v:
Analytical Biochemistry. 404:186-192
LRRK2 is a large and complex protein that possesses kinase and GTPase activities and has emerged as the most relevant player in PD pathogenesis possibly through a toxic gain-of-function mechanism. Kinase activity is a critical component of LRRK2 func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1355d152d1ee8eb13257db35da4c0ab
https://doi.org/10.1016/j.ab.2010.05.033
https://doi.org/10.1016/j.ab.2010.05.033