Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Alexandra Crowe"'
Autor:
Alexandra Crowe, Wei Yue
Publikováno v:
Bio-Protocol, Vol 13, Iss 2 (2023)
Externí odkaz:
https://doaj.org/article/cc4b0c44da5e49cfb63d7a2050f2e0a5
Autor:
Alexandra Crowe, Wei Yue
Publikováno v:
Bio-Protocol, Vol 9, Iss 24 (2019)
Semi-quantitative immunohistochemistry (IHC) is a powerful method for investigating protein expression and localization within tissues that involves using software, such as the freely available Fiji (ImageJ), to conduct deconvolution and downstream a
Externí odkaz:
https://doaj.org/article/113b88c1760041b7a1578da10c4a95ed
Publikováno v:
Bio-Protocol, Vol 9, Iss 16 (2019)
Organic anion transporting polypeptide (OATP) 1B1 is a liver-specific transport protein that plays an important role in hepatic drug disposition. It transports many drugs from the blood into the liver, including lipid-lowering statins. The c. 521 T>C
Externí odkaz:
https://doaj.org/article/53a1021f8f704c7e92dda80132bf4967
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0186924 (2017)
OATP1B1 and OATP1B3 mediate hepatic uptake of many drugs (e.g., statins) and can mediate transporter-mediated drug-drug-interactions (DDIs). Bortezomib is the first-in-class proteasome inhibitor drug approved by the U. S. Food and Drug Administration
Externí odkaz:
https://doaj.org/article/86bbcde6c6c747709fffcfec4808043e
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 3, p 855 (2018)
Organic anion transporting polypeptides (OATP) 1B1 and OATP1B3 are important hepatic transporters that mediate the uptake of many clinically important drugs, including statins from the blood into the liver. Reduced transport function of OATP1B1 and O
Externí odkaz:
https://doaj.org/article/a886acbb5a6d4caca67e85c50c4cebef
Publikováno v:
Journal of Convention & Event Tourism. 23:269-296
Autor:
Wei Yue, Khondoker Alam, Taleah Farasyn, Qiang Liu, Kai Ding, Alexandra Crowe, Sonia Pahwa, Ruhul Kayesh, Oliver Hatley, Sibylle Neuhoff
Publikováno v:
J Pharm Sci
Organic anion transporting polypeptides (OATP) 1B1 and OATP1B3 are important determinants of transporter-mediated drug-drug interactions (DDIs). Current studies assessed the OATP1B1 and OATP1B3-mediated DDI potential of vemurafenib, a kinase inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::545872511e4fa8529411df0cd308674d
https://europepmc.org/articles/PMC7750294/
https://europepmc.org/articles/PMC7750294/
Autor:
Taleah Farasyn, Alexandra Crowe, Sonia Pahwa, Khondoker Alam, Kai Ding, Wei Yue, Sibylle Neuhoff, Oliver Hatley
Publikováno v:
Journal of Pharmaceutical Sciences. 106:2123-2135
Present studies determined the effects of pretreatment with rifampicin, an organic anion-transporting polypeptide (OATP) inhibitor, and the tyrosine kinase inhibitor dasatinib on OATP1B1- and OATP1B3-mediated transport, and evaluated the OATP-mediate
Autor:
Erin Rubin, Wei Yue, Kar Ming Fung, Jonathan Miller, Kai Ding, Feng Yin, Sonia Pahwa, Alexandra Crowe, Khondoker Alam, Wei Zheng
Publikováno v:
Pharm Res
PURPOSE: Membrane transport protein organic anion transporting polypeptide (OATP) 1B1 mediates hepatic uptake of many drugs (e.g. statins). The OATP1B1 c.521T>C (p. V174A) polymorphism has reduced transport activity. Conflicting in vitro results exis
Autor:
TuKiet T. Lam, Alexandra Crowe, Jean Kanyo, Kai Ding, Taleah Farasyn, Oliver Hatley, Sibylle Neuhoff, Wei Yue, Khondoker Alam
Publikováno v:
J Pharm Sci
Organic anion transporting polypeptides (OATP)1B1 and OATP1B3 mediate hepatic uptake of many drugs including lipid-lowering statins. Current studies determined the OATP1B1/1B3-mediated drug-drug interaction (DDI) potential of mammalian target of rapa