Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Alexandra Christodoulou"'
Autor:
Alexandra Christodoulou, Julia Y. Tsai, Nutthakarn Suwankitwat, Andreas Anderson, Brian M. Iritani
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Inborn errors of immunity (IEI) are a group of diseases in humans that typically present as increased susceptibility to infections, autoimmunity, hyperinflammation, allergy, and in some cases malignancy. Among newly identified genes linked to IEIs in
Externí odkaz:
https://doaj.org/article/1f31fd16313e409a93c34d9cb7bebf71
Autor:
Alan Avalos, Jacob T. Tietsort, Nutthakarn Suwankitwat, Jonathan D. Woods, Shaun W. Jackson, Alexandra Christodoulou, Christopher Morrill, H. Denny Liggitt, Chengsong Zhu, Quan-Zhen Li, Kevin K. Bui, Heon Park, Brian M. Iritani
Publikováno v:
JCI Insight, Vol 7, Iss 9 (2022)
Hematopoietic protein-1 (Hem-1) is a member of the actin-regulatory WASp family verprolin homolog (WAVE) complex. Loss-of-function variants in the NCKAP1L gene encoding Hem-1 were recently discovered to result in primary immunodeficiency disease (PID
Externí odkaz:
https://doaj.org/article/7b1c015f36ab4961996e21a2e851809a
Autor:
Pierre Sujobert, Laury Poulain, Etienne Paubelle, Florence Zylbersztejn, Adrien Grenier, Mireille Lambert, Elizabeth C. Townsend, Jean-Marie Brusq, Edwige Nicodeme, Justine Decrooqc, Ina Nepstad, Alexa S. Green, Johanna Mondesir, Marie-Anne Hospital, Nathalie Jacque, Alexandra Christodoulou, Tiffany A. Desouza, Olivier Hermine, Marc Foretz, Benoit Viollet, Catherine Lacombe, Patrick Mayeux, David M. Weinstock, Ivan C. Moura, Didier Bouscary, Jerome Tamburini
Publikováno v:
Cell Reports, Vol 11, Iss 9, Pp 1446-1457 (2015)
AMPK is a master regulator of cellular metabolism that exerts either oncogenic or tumor suppressor activity depending on context. Here, we report that the specific AMPK agonist GSK621 selectively kills acute myeloid leukemia (AML) cells but spares no
Externí odkaz:
https://doaj.org/article/9222733afbf84f689b27bbb06ca36d9b