Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Alexandra Chittka"'
Autor:
Rocio Enriquez-Gasca, Poppy A. Gould, Hale Tunbak, Lucia Conde, Javier Herrero, Alexandra Chittka, Christine R. Beck, Robert Gifford, Helen M. Rowe
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112625- (2023)
Summary: Endogenous retroviruses (ERVs) have rewired host gene networks. To explore the origins of co-option, we employed an active murine ERV, IAPEz, and an embryonic stem cell (ESC) to neural progenitor cell (NPC) differentiation model. Transcripti
Externí odkaz:
https://doaj.org/article/6a9e0395bbad4b8485afd09c5158792b
Autor:
Annika Schmidt, Jana Frei, Ansgar Poetsch, Alexandra Chittka, Hui Zhang, Chris Aßmann, Anne Lehmkuhl, Uta-Maria Bauer, Ulrike A. Nuber, M. Cristina Cardoso
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Rett syndrome is a human intellectual disability disorder that is associated with mutations in the X-linked MECP2 gene. The epigenetic reader MeCP2 binds to methylated cytosines on the DNA and regulates chromatin organization. We have shown previousl
Externí odkaz:
https://doaj.org/article/a32a708dc9b24bf0862ff7e3198c2f3e
Autor:
Alexandra Chittka, Lars Chittka
Publikováno v:
PLoS Biology, Vol 8, Iss 11, p e1000532 (2010)
Externí odkaz:
https://doaj.org/article/128200be8d044c919202697c148c6987
Autor:
Alexandra Chittka
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e13807 (2010)
Epigenetic modifications regulate key transitions in cell fate during development of the central nervous system (CNS). During cortical development the initial population of proliferative neuroepithelial precursor cells give rise to neurons and then g
Externí odkaz:
https://doaj.org/article/a9706cd1e1f743eca20377ef74a39022
Autor:
Petra Mlcochova, Katherine A. Sutherland, Alexandra Chittka, Christiana Georgiou, Gina M. Lenzi, Mahdad Noursadeghi, Stuart J. D. Neil, Sarah A. Watters, Robertus A. M. de Bruin, Asim Khwaja, Simon Yona, Baek Kim, Cosetta Bertoli, Jan Rehwinkel, Greg J. Towers, Matthew C. Gage, Ravindra K. Gupta
Publikováno v:
Mlcochova, P, Sutherland, K A, Watters, S A, Bertoli, C, de Bruin, R A M, Rehwinkel, J, Neil, S J, Lenzi, G M, Kim, B, Khwaja, A, Gage, M C, Georgiou, C, Chittka, A, Yona, S, Noursadeghi, M, Towers, G J & Gupta, R K 2017, ' A G1-like state allows HIV-1 to bypass SAMHD1 restriction in macrophages ', The EMBO journal, vol. 36, no. 5, pp. 604-616 . https://doi.org/10.15252/embj.201696025
The EMBO Journal
The EMBO Journal
An unresolved question is how HIV‐1 achieves efficient replication in terminally differentiated macrophages despite the restriction factor SAMHD1. We reveal inducible changes in expression of cell cycle‐associated proteins including MCM2 and cycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b827e597ca2e337f38562406fc199183
https://doi.org/10.15252/embj.201696025
https://doi.org/10.15252/embj.201696025
Publikováno v:
Journal of insect physiology. 116
Proper neural development in insects depends on the controlled proliferation and differentiation of neural precursors. In holometabolous insects, these processes must be coordinated during larval and pupal development. Recently, protein arginine meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7553ee3537e2f506633327b8d97403b2
https://pubmed.ncbi.nlm.nih.gov/31039373
https://pubmed.ncbi.nlm.nih.gov/31039373
Publikováno v:
Journal of Biological Chemistry
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Background: Neural stem cells generate all the cell types of the central nervous system. Results: Transcription factor, PRDM4, recruits protein arginine methyltransferase 5 (PRMT5) to control the timing of neurogenesis. Conclusion: PRDM4- and PRMT5-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3e2daf02b02f2a8eed9ad265e76d86d
https://doi.org/10.1074/jbc.m112.392746
https://doi.org/10.1074/jbc.m112.392746
Publikováno v:
Biochemical and biophysical research communications. 474(2)
PRDM4 is a member of the PRDM family of transcriptional regulators which control various aspects of cellular differentiation and proliferation. PRDM proteins exert their biological functions both in the cytosol and the nucleus of cells. All PRDM prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411407654084fc439605de9917240994
https://pubmed.ncbi.nlm.nih.gov/27125459
https://pubmed.ncbi.nlm.nih.gov/27125459
Publikováno v:
Current Biology. 22:R835-R838
Summary Social insects represent a unique model for how the same genome can give rise to entirely different phenotypes — soldiers, common labourers, and queens. New research on ants and honeybees points to DNA methylation as a crucial factor in det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c82042749a2263e99a5684bda6cc7e4
https://doi.org/10.1016/j.cub.2012.07.045
https://doi.org/10.1016/j.cub.2012.07.045
Publikováno v:
Journal of Endocrinology. 198:185-191
Although the zonation of the adrenal cortex has a clear functional role, the mechanisms that maintain it remain largely conjectural. The concept that an outer proliferative layer gives rise to cells that migrate inwards, adopting sequentially the zon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::820f8b1051e313fb97f3aa5233dd6645
https://doi.org/10.1677/joe-08-0084
https://doi.org/10.1677/joe-08-0084