Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Alexandra Chang-Graham"'
Autor:
Melinda A. Engevik, Zhongcheng Shi, James Versalovic, Faith D. Ihekweazu, Kathleen M. Hoch, Anthony M. Haag, Jennifer K. Spinler, Deborah Schady, Wenly Ruan, Sigmund J. Haidacher, Beatrice Herrmann, Magdalena Esparza, Susan Venable, Alexandra Chang-Graham, Joseph M. Hyser, Amy C. Engevik, Thomas D. Horvath, Kristen A. Engevik, Berkley Luck
Publikováno v:
Gut Microbes
article-version (VoR) Version of Record
Gut Microbes, Vol 13, Iss 1 (2021)
article-version (VoR) Version of Record
Gut Microbes, Vol 13, Iss 1 (2021)
Endoplasmic reticulum (ER) stress compromises the secretion of MUC2 from goblet cells and has been linked with inflammatory bowel disease (IBD). Although Bifidobacterium can beneficially modulate mucin production, little work has been done investigat
Autor:
Kristen A. Engevik, Annie Goodwin, Alexandra Chang-Graham, Sigmund J. Haidacher, Joseph M. Hyser, Yuying Liu, Jasmin Freeborn, Faith D. Ihekweazu, Melinda A. Engevik, Susan Venable, Robert Fultz, Anthony M. Haag, James Versalovic, Deborah Schady, Zhongcheng Shi, Thomas D. Horvath, Evelyn S. Park, Wenly Ruan, Jennifer K. Spinler
Publikováno v:
Am J Pathol
The intestinal microbiota influences the development and function of the mucosal immune system. However, the exact mechanisms by which commensal microbes modulate immunity is not clear. We previously demonstrated that commensal Bacteroides ovatus ATC
Human-Derived Bifidobacterium dentium Modulates the Mammalian Serotonergic System and Gut–Brain Axis
Autor:
Noah F. Shroyer, Amy C. Engevik, Sridevi Devaraj, Bradley T. Endres, Berkley Luck, James Versalovic, Heather A. Danhof, Faith D. Ihekweazu, Anne Hall, Zhongcheng Shi, Chonnikant Visuthranukul, Kevin W. Garey, Anthony M. Haag, Robert A. Britton, Sigmund J. Haidacher, Melinda A. Engevik, Alexandra Chang-Graham, Joseph M. Hyser, Thomas D. Horvath
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 221-248 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims The human gut microbiota can regulate production of serotonin (5-hydroxytryptamine [5-HT]) from enterochromaffin cells. However, the mechanisms underlying microbial-induced serotonin signaling are not well understood. Methods Adult
Autor:
Kristen A. Engevik, Jennifer M. Auchtung, Melinda A. Engevik, James Versalovic, Alexandra Chang-Graham, Joseph M. Hyser, Amy C. Engevik, Wenly Ruan, Ruth Ann Luna, Jennifer K. Spinler
Publikováno v:
ACS Infectious Diseases. 7:1126-1142
It is widely accepted that the pathogen Clostridioides difficile exploits an intestinal environment with an altered microbiota, but the details of these microbe-microbe interactions are unclear. Adherence and colonization of mucus has been demonstrat
Autor:
Kristen A. Engevik, Nadim J. Ajami, Jacob L. Perry, Lori Banks, Diane S. Hutchinson, Melinda A. Engevik, Joseph F. Petrosino, Alexandra Chang-Graham, Joseph M. Hyser
Publikováno v:
Gut Microbes, Vol 11, Iss 5, Pp 1324-1347 (2020)
Gut Microbes
Gut Microbes
Multiple studies have identified changes within the gut microbiome in response to diarrheal-inducing bacterial pathogens. However, examination of the microbiome in response to viral pathogens remains understudied. Compounding this, many studies use f
Autor:
Robert A. Britton, James Versalovic, Alexandra Chang-Graham, Joseph M. Hyser, Wenly Ruan, Melinda A. Engevik, Kristen A. Engevik, Sara C. Di Rienzi, Anne Hall, Annie Goodwin, Heather A. Danhof, Susan Venable, Zhongcheng Shi
Publikováno v:
The Journal of Physiology. 598:3085-3105
Key points Enteroids are a physiologically relevant model to examine the human intestine and its functions. Previously, the measurable cytokine response of human intestinal enteroids has been limited following exposure to host or microbial pro-inflam
Autor:
James Versalovic, Robert A. Britton, Melinda A. Engevik, Heather A. Danhof, Kevin W. Garey, Beatrice Herrmann, Alexandra Chang-Graham, Joseph M. Hyser, Kristen A. Engevik, Bradley T. Endres, Jennifer K. Spinler
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 318:G870-G888
Clostridioides difficile is an important nosocomial pathogen that produces toxins to cause life-threatening diarrhea and colitis. Toxins bind to epithelial receptors and promote the collapse of the actin cytoskeleton. C. difficile toxin activity is c
Autor:
Heather A. Danhof, Robert A. Britton, Susan Venable, Jennifer K. Spinler, Kristen A. Engevik, Colleen K. Brand, Kendal D. Hirschi, Xinli Liu, Zhongcheng Shi, Amy C. Engevik, Alexandra Chang-Graham, Joseph M. Hyser, James Versalovic, Melinda A. Engevik, Yanling Zhao, Evan S. Krystofiak, Wenly Ruan
Publikováno v:
mBio
mBio, Vol 12, Iss 2 (2021)
mBio, Vol 12, Iss 2 (2021)
Several studies have identified an increased abundance of Fusobacterium in the intestinal tracts of patients with colon cancer, liver cirrhosis, primary sclerosing cholangitis, gastroesophageal reflux disease, HIV infection, and alcoholism. However,
Autor:
Joseph A. Sorg, Heather A. Danhof, Alexandra Chang-Graham, Joseph M. Hyser, Jennifer K. Spinler, James Versalovic, Melinda A. Engevik, Robert A. Britton, Ritu Shrestha, Anthony M. Haag, Mahmoud A. Mohammad
Publikováno v:
Gut Microbes, Vol 12, Iss 1 (2020)
Gut Microbes
article-version (VoR) Version of Record
Gut Microbes
article-version (VoR) Version of Record
Antibiotic resistance is one of the world’s greatest public health challenges and adjunct probiotic therapies are strategies that could lessen this burden. Clostridioides difficile infection (CDI) is a prime example where adjunct probiotic therapie
Autor:
J. Thomas Gebert, Melinda A. Engevik, Joel C. Nelson, Kristen A. Engevik, Robert A. Britton, Jacob L. Perry, Joseph S. Kellen, Francesca J. Scribano, James Versalovic, Mary K. Estes, Heather A. Danhof, Narayan P. Sastri, Alexandra Chang-Graham, Joseph M. Hyser, Alicia C. Strtak
Publikováno v:
Science
Riding the calcium waves Rotavirus causes severe diarrhea and vomiting in children worldwide, yet how infection causes these diseases remains poorly understood. A leading theory is that virus-infected cells secrete paracrine signaling molecules that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2eb72ea7fd7c619c72a42da5e1fed53