Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Alexandra C. McPherron"'
Autor:
Young Jae Bahn, Hariom Yadav, Paolo Piaggi, Brent S. Abel, Oksana Gavrilova, Danielle A. Springer, Ioannis Papazoglou, Patricia M. Zerfas, Monica C. Skarulis, Alexandra C. McPherron, Sushil G. Rane
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 13 (2023)
Understanding how skeletal muscle fiber proportions are regulated is vital to understanding muscle function. Oxidative and glycolytic skeletal muscle fibers differ in their contractile ability, mitochondrial activity, and metabolic properties. Fiber-
Externí odkaz:
https://doaj.org/article/e661227f09e44dff81ed08f7b6f00ce5
Autor:
Tingqing Guo, William Jou, Tatyana Chanturiya, Jennifer Portas, Oksana Gavrilova, Alexandra C McPherron
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4937 (2009)
Myostatin (Mstn) is a secreted growth factor expressed in skeletal muscle and adipose tissue that negatively regulates skeletal muscle mass. Mstn(-/-) mice have a dramatic increase in muscle mass, reduction in fat mass, and resistance to diet-induced
Externí odkaz:
https://doaj.org/article/36577fc9aec345a8b481c61dabc095df
Publikováno v:
International Journal of Biological Sciences
Retrospective and prospective studies show that lean mass or strength is positively associated with metabolic health. Mice deficient in myostatin, a growth factor that negatively regulates skeletal muscle mass, have increased muscle and body weights
Publikováno v:
International Journal of Biological Sciences
Type 1 diabetes mellitus (T1DM), or insulin dependent DM, is accompanied by decreased muscle mass. The growth factor myostatin (MSTN) is a negative regulator of muscle growth, and a loss of MSTN signaling has been shown to increase muscle mass and pr
Autor:
Alexandra C. McPherron
Publikováno v:
Circulation Research. 113:487-491
In an intriguing new study, Loffredo et al report that joining the circulation of old mice with that of young mice reduces age-related cardiac hypertrophy. They also found that the growth factor growth/differentiation factor 11 is a circulating negat
Autor:
Irini Manoli, Andrew E. Arai, Warner M. Burch, William A. Gahl, Angela Dispenzieri, Elisabeth J. Rushing, Qian Wang, Justin Y. Kwan, Maria Tsokos, Alexandra C. McPherron
Publikováno v:
Molecular Genetics and Metabolism. 108:249-254
Amyloid myopathy associated with a plasma cell dyscrasia is a rare cause of muscle hypertrophy. It can be a challenging diagnosis, since pathological findings are often elusive. In addition, the mechanism by which immunoglobulin light-chain depositio
Publikováno v:
Adipocyte
Skeletal muscle insulin resistance is a predictor of the development of type 2 diabetes and maintenance of adequate muscle glucose disposal in muscle may help to prevent diabetes. Lipodystrophy is a type of diabetes caused by a reduction of white adi
Autor:
Alexandra C. McPherron
Publikováno v:
Acta physiologica (Oxford, England). 217(1)
Autor:
Oksana Gavrilova, William Jou, Alexandra C. McPherron, Tingqing Guo, Jennifer Portas, Nichole D. Bond
Publikováno v:
Diabetes
Lipodystrophies are characterized by a loss of white adipose tissue, which causes ectopic lipid deposition, peripheral insulin resistance, reduced adipokine levels, and increased food intake (hyperphagia). The growth factor myostatin (MSTN) negativel
Publikováno v:
Muscle & Nerve. 42:355-362
The growth factor myostatin (Mstn) is a negative regulator of skeletal muscle mass. Mstn(-/-) muscles are hypertrophied, stronger, and more glycolytic than Mstn(+/+) muscles, suggesting that they might not perform endurance exercise as well as Mstn(+