Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Alexandra C. Chadwick"'
Autor:
Kallanthottathil G. Rajeev, Nicole M. Gaudelli, Yusuf S. Nasrullah, Soumyashree A. Gangopadhyay, Andrew M. Bellinger, Sara P. Garcia, James Madsen, Jamie E. DeNizio, Athul Sanjeev, Lisa N. Kasiewicz, Giuseppe Ciaramella, Aaron Beach, Ellen Rohde, Anne Marie Mazzola, Thomas V. Colace, Kui Wang, Sowmya Iyer, Caroline W. Reiss, Padma Malyala, Steven H. Y. Fan, Victoria Clendaniel, Christopher J. Cheng, Jennifer Lavoie, Taiji Mizoguchi, Yuri Matsumoto, Madeleine Shay, Kiran Musunuru, Leslie E. Stolz, Maurine C. Braun, Chaitali Dutta, Ying K. Tam, Joseph Nneji, Ryan Garrity, Alexandra C. Chadwick, Souvik Biswas, Michael Amaonye, John D. Ganey, Mary R. Stahley, Huilan Ren, Huei-Mei Chen, Kathleen Berth, Sekar Kathiresan
Publikováno v:
Nature. 593:429-434
Gene-editing technologies, which include the CRISPR–Cas nucleases1–3 and CRISPR base editors4,5, have the potential to permanently modify disease-causing genes in patients6. The demonstration of durable editing in target organs of nonhuman primat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::202cb5c958a9c7ceda5f4b4bf29aa718
https://doi.org/10.1038/s41586-021-03534-y
https://doi.org/10.1038/s41586-021-03534-y
Autor:
Ellen Rohde, Christopher J. Cheng, Souvik Biswas, Anne Marie Mazzola, Kallanthottathil G. Rajeev, Aaron Beach, Huilan Ren, Lisa N. Kasiewicz, Chaitali Dutta, Padma Malyala, Kiran Musunuru, Sekar Kathiresan, Andrew M. Bellinger, Alexandra C. Chadwick
Standard lipid nanoparticles (LNPs) deliver gene editing cargoes to hepatocytes through receptor-mediated uptake via the low-density lipoprotein receptor (LDLR). Homozygous familial hypercholesterolemia (HoFH) is a morbid genetic disease characterize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37b45fcbbf0d5ddb47b59a097a02d6ce
https://doi.org/10.1101/2021.11.08.467731
https://doi.org/10.1101/2021.11.08.467731
Autor:
Alexandra C Chadwick, Rebecca L Holme, Yiliang Chen, Michael J Thomas, Mary G Sorci-Thomas, Roy L Silverstein, Kirkwood A Pritchard, Daisy Sahoo
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123138 (2015)
High density lipoproteins (HDL) are considered athero-protective, primarily due to their role in reverse cholesterol transport, where they transport cholesterol from peripheral tissues to the liver for excretion. The current study was designed to det
Externí odkaz:
https://doaj.org/article/dd6032d5dc634b9c84eeabbe99420d20
Autor:
Alexandra C Chadwick, Daisy Sahoo
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45660 (2012)
In rodents, SR-BI has been firmly established as a physiologically relevant HDL receptor that mediates removal of HDL-cholesteryl esters (CE). However, its role in human lipoprotein metabolism is less defined. Recently, two unique point mutations in
Externí odkaz:
https://doaj.org/article/a7e36680f3614d75a83bc32ca96b097a
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 37:1741-1747
Objective— High-efficiency genome editing to disrupt therapeutic target genes, such as PCSK9 (proprotein convertase subtilisin/kexin type 9), has been demonstrated in preclinical animal models, but there are safety concerns because of the unpredict
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a2cd531460b91e3440c05bf3b556737
https://doi.org/10.1161/atvbaha.117.309881
https://doi.org/10.1161/atvbaha.117.309881
Autor:
Brian F. Volkman, Francis C. Peterson, Davin R. Jensen, Alexandra C. Chadwick, Daisy Sahoo, Sarah C. Proudfoot, Philip T. Lange, Paul J. Hanson
Publikováno v:
Structure. 25:446-457
The interaction of high density lipoprotein (HDL) with its receptor, scavenger receptor BI (SR-BI), is critical for lowering plasma cholesterol levels and reducing the risk for cardiovascular disease. The HDL/SR-BI complex facilitates delivery of cho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a409e0eb6e9275fb6ba34a39f8460b10
https://doi.org/10.1016/j.str.2017.01.001
https://doi.org/10.1016/j.str.2017.01.001
Autor:
Heather A. Hartman, Nicholas J. Ahn, Deepthi Alapati, Kiran Musunuru, Jeremy Katzen, Avery C. Rossidis, Hiaying Li, Michael F. Beers, Edward E. Morrisey, Yaniv Tomer, William J. Zacharias, William H. Peranteau, Su Zhou, Barbara E. Coons, Kshitiz Singh, John D. Stratigis, Alexandra C. Chadwick
Monogenic lung diseases that are caused by mutations in surfactant genes of the pulmonary epithelium are marked by perinatal lethal respiratory failure or chronic diffuse parenchymal lung disease with few therapeutic options. Using a CRISPR fluoresce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f962fe89ad5ef2b700d153b5cdf19ac9
https://europepmc.org/articles/PMC6822403/
https://europepmc.org/articles/PMC6822403/
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 38
High density lipoproteins (HDL) facilitate reverse cholesterol transport (RCT), the process by which cholesterol effluxed from peripheral tissues is delivered via selective uptake to the liver for excretion. These processes are mediated by HDL's high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::052b1d9eececad48842ad9d1f7cdd446
https://doi.org/10.1161/atvb.38.suppl_1.563
https://doi.org/10.1161/atvb.38.suppl_1.563
Autor:
Wenjian Lv, Alexandra E Sperry, A. Christina Vourakis, Kiran Musunuru, Xiao Wang, Wenjun Li, Alexandra C. Chadwick
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 38
Angiopoietin-like 3 ( ANGPTL3 ) associates strongly with blood lipid phenotypes in human genetics studies and has thus emerged as promising therapeutic target for plasma lipids. We examined the coding regions of ANGPTL3 and identified 82 rare variant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5012328fdefe6a3558d54ab371ce0cf
https://doi.org/10.1161/atvb.38.suppl_1.013
https://doi.org/10.1161/atvb.38.suppl_1.013
Autor:
William H. Peranteau, William J. Zacharias, Barbara E. Coons, Deepthi Alapati, Alexandra C. Chadwick, Kshitiz Singh, Edward E. Morrisey, Haiying Li, John D. Stratigis, Wenjian Lv, Rajan Jain, Li Li, Nicholas J. Ahn, Kiran Musunuru, Philip W. Zoltick, Avery C. Rossidis, Heather A. Hartman
Publikováno v:
Cardiovascular Research
Nature medicine
Nature medicine
In utero gene editing has the potential to prenatally treat genetic diseases that result in significant morbidity and mortality before or shortly after birth. We assessed the viral vector-mediated delivery of clustered regularly interspaced short pal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ccaae8b897439ca1f66181cdf77c632
https://pubmed.ncbi.nlm.nih.gov/30824914
https://pubmed.ncbi.nlm.nih.gov/30824914