Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Alexandra C. Brown"'
Autor:
Jay C. Horvat, Richard Y. Kim, Natasha Weaver, Christopher Augood, Alexandra C. Brown, Chantal Donovan, Pierrick Dupre, Lakshitha Gunawardhana, Jemma R. Mayall, Nicole G. Hansbro, Avril A. B. Robertson, Luke A. J. O’Neill, Matthew A. Cooper, Elizabeth G. Holliday, Philip M. Hansbro, Peter G. Gibson
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-14 (2023)
Abstract Background Increased airway NLRP3 inflammasome-mediated IL-1β responses may underpin severe neutrophilic asthma. However, whether increased inflammasome activation is unique to severe asthma, is a common feature of immune cells in all infla
Externí odkaz:
https://doaj.org/article/60288ffe24fd40148d0b5a1960f9d444
Autor:
Xiaofan Tu, Henry M. Gomez, Richard Y. Kim, Alexandra C. Brown, Emma de Jong, Izabela Galvao, Alen Faiz, Anthony Bosco, Jay C. Horvat, Philip Hansbro, Chantal Donovan
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Lung transcriptomics studies in asthma have provided valuable information in the whole lung context, however, deciphering the individual contributions of the airway and parenchyma in disease pathogenesis may expedite the development of novel
Externí odkaz:
https://doaj.org/article/911ea9c2ab394ba2934f8c80d24c27d0
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Recent advances in mouse models of experimental asthma coupled with vast improvements in systems that assess respiratory physiology have considerably increased the accuracy and human relevance of the outputs from these studies. In fact, these models
Externí odkaz:
https://doaj.org/article/90ea8e3c33224ff3b33b6fd9530d9f36
Autor:
Celine Vidaillac, Valerie Fei Lee Yong, Marie-Stephanie Aschtgen, Jing Qu, Shuowei Yang, Guangfu Xu, Zi Jing Seng, Alexandra C. Brown, Md Khadem Ali, Tavleen K. Jaggi, Jagadish Sankaran, Yong Hwee Foo, Francesco Righetti, Anu Maashaa Nedumaran, Micheál Mac Aogáin, Dan Roizman, Jean-Alexandre Richard, Thomas R. Rogers, Masanori Toyofuku, Dahai Luo, Edmund Loh, Thorsten Wohland, Bertrand Czarny, Jay C. Horvat, Philip M. Hansbro, Liang Yang, Liang Li, Staffan Normark, Birgitta Henriques-Normark, Sanjay H. Chotirmall
Publikováno v:
mBio, Vol 11, Iss 6 (2020)
Externí odkaz:
https://doaj.org/article/c28fd07a0c564aec9c94a5818f69e570
Autor:
Celine Vidaillac, Valerie Fei Lee Yong, Marie-Stephanie Aschtgen, Jing Qu, Shuowei Yang, Guangfu Xu, Zi Jing Seng, Alexandra C. Brown, Md Khadem Ali, Tavleen K. Jaggi, Jagadish Sankaran, Yong Hwee Foo, Francesco Righetti, Anu Maashaa Nedumaran, Micheál Mac Aogáin, Dan Roizman, Jean-Alexandre Richard, Thomas R. Rogers, Masanori Toyofuku, Dahai Luo, Edmund Loh, Thorsten Wohland, Bertrand Czarny, Jay C. Horvat, Philip M. Hansbro, Liang Yang, Liang Li, Staffan Normark, Birgitta Henriques-Normark, Sanjay H. Chotirmall
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
ABSTRACT Estrogen, a major female sex steroid hormone, has been shown to promote the selection of mucoid Pseudomonas aeruginosa in the airways of patients with chronic respiratory diseases, including cystic fibrosis. This results in long-term persist
Externí odkaz:
https://doaj.org/article/a70f533655e045bc87d30e38bc6cedeb
Autor:
Rebecca J. Marshall, Pornthida Armart, Katina D. Hulme, Keng Yih Chew, Alexandra C. Brown, Philip M. Hansbro, Conor J. Bloxham, Melanie Flint, Katharina Ronacher, Helle Bielefeldt-Ohmann, Linda A. Gallo, Kirsty R. Short
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT People with diabetes are two times more likely to die from influenza than people with no underlying medical condition. The mechanisms underlying this susceptibility are poorly understood. In healthy individuals, small and short-lived postpra
Externí odkaz:
https://doaj.org/article/e7526e11425e4113be3ebc0f2d499ad6
Autor:
Alexandra C. Brown, Daniel L. M. Suess
Publikováno v:
Journal of the American Chemical Society. 145:2075-2080
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4b4e9cc929e9f7304355dbdd426c5a0
https://doi.org/10.1021/jacs.2c13126
https://doi.org/10.1021/jacs.2c13126
Publikováno v:
J Am Chem Soc
Synthetic [Fe(4)S(4)] clusters with Fe–R groups (R = alkyl/benzyl) are shown to release organic radicals on an [Fe(4)S(4)](3+)–R/[Fe(4)S(4)](2+) redox couple, the same that has been proposed for a radical-generating intermediate in the superfamil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a69fd96975aa748a574fc1c10e7a16
https://doi.org/10.1021/jacs.2c03195
https://doi.org/10.1021/jacs.2c03195
Autor:
Alexandra C. Brown, Daniel L. M. Suess
Publikováno v:
Inorg Chem
Reported herein are alkyne and alkene adducts of synthetic [Fe(4)S(4)](+) clusters that model intermediates and inhibitor-bound states in enzymes involved in isoprenoid biosynthesis. Treatment of the N-heterocyclic carbene-ligated cluster [(IMes)(3)F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ffc4fe9876b5550e8615d90ea85ed6
https://doi.org/10.1021/acs.inorgchem.2c01353
https://doi.org/10.1021/acs.inorgchem.2c01353
Publikováno v:
Nature Synthesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c4dbdeccbf3f401a1a3f99854f5255e
https://doi.org/10.1038/s44160-023-00286-7
https://doi.org/10.1038/s44160-023-00286-7