Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Alexandra C Walls"'
Autor:
Tyler N Starr, Allison J Greaney, Cameron M Stewart, Alexandra C Walls, William W Hannon, David Veesler, Jesse D Bloom
Publikováno v:
PLoS Pathogens, Vol 18, Iss 11, p e1010951 (2022)
SARS-CoV-2 continues to acquire mutations in the spike receptor-binding domain (RBD) that impact ACE2 receptor binding, folding stability, and antibody recognition. Deep mutational scanning prospectively characterizes the impacts of mutations on thes
Externí odkaz:
https://doaj.org/article/935a02fbd2d6495d8f961be0fd3e02fe
Autor:
Marcos C. Miranda, Elizabeth Kepl, Mary Jane Navarro, Chengbo Chen, Max Johnson, Kaitlin R. Sprouse, Cameron Stewart, Anne Palser, Adian Valdez, Deleah Pettie, Claire Sydeman, Cassandra Ogohara, John C. Kraft, Minh Pham, Michael Murphy, Sam Wrenn, Brooke Fiala, Rashmi Ravichandran, Daniel Ellis, Lauren Carter, Davide Corti, Paul Kellam, Kelly Lee, Alexandra C. Walls, David Veesler, Neil P. King
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-14 (2024)
Abstract We previously described a two-component protein nanoparticle vaccine platform that displays 60 copies of the SARS-CoV-2 spike protein RBD (RBD-NP). The vaccine, when adjuvanted with AS03, was shown to elicit robust neutralizing antibody and
Externí odkaz:
https://doaj.org/article/649dcf2c588340c39547078121604655
Autor:
Adam S. Dingens, Katharine H. D. Crawford, Amanda Adler, Sarah L. Steele, Kirsten Lacombe, Rachel Eguia, Fatima Amanat, Alexandra C. Walls, Caitlin R. Wolf, Michael Murphy, Deleah Pettie, Lauren Carter, Xuan Qin, Neil P. King, David Veesler, Florian Krammer, Jane A. Dickerson, Helen Y. Chu, Janet A. Englund, Jesse D. Bloom
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-6 (2020)
COVID-19 disease is less common in children than adults, but the extent to which SARS-CoV-2 infections are missed through symptom-driven testing is not well understood. In this study, the authors show that approximately 1% of children seeking care fo
Externí odkaz:
https://doaj.org/article/399ad20101ad4ac9854352e24ec39d01
Autor:
Qing Xiong, Lei Cao, Chengbao Ma, M. Alejandra Tortorici, Chen Liu, Junyu Si, Peng Liu, Mengxue Gu, Alexandra C. Walls, Chunli Wang, Lulu Shi, Fei Tong, Meiling Huang, Jing Li, Chufeng Zhao, Chao Shen, Yu Chen, Huabin Zhao, Ke Lan, Davide Corti, David Veesler, Xiangxi Wang, Huan Yan
Publikováno v:
Nature. 612:748-757
Middle East respiratory syndrome coronavirus (MERS-CoV) and several bat coronaviruses use dipeptidyl peptidase-4 (DPP4) as an entry receptor1–4. However, the receptor for NeoCoV—the closest known MERS-CoV relative found in bats—remains unclear5
Autor:
John E. Bowen, Amin Addetia, Ha V. Dang, Cameron Stewart, Jack T. Brown, William K. Sharkey, Kaitlin R. Sprouse, Alexandra C. Walls, Ignacio G. Mazzitelli, Jennifer K. Logue, Nicholas M. Franko, Nadine Czudnochowski, Abigail E. Powell, Exequiel Dellota, Kumail Ahmed, Asefa Shariq Ansari, Elisabetta Cameroni, Andrea Gori, Alessandra Bandera, Christine M. Posavad, Jennifer M. Dan, Zeli Zhang, Daniela Weiskopf, Alessandro Sette, Shane Crotty, Najeeha Talat Iqbal, Davide Corti, Jorge Geffner, Gyorgy Snell, Renata Grifantini, Helen Y. Chu, David Veesler
Publikováno v:
Science. 377:890-894
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern comprises several sublineages, with BA.2 and BA.2.12.1 having replaced the previously dominant BA.1 and with BA.4 and BA.5 increasing in prevalence worldwide.
Autor:
Jun Siong Low, Josipa Jerak, M. Alejandra Tortorici, Matthew McCallum, Dora Pinto, Antonino Cassotta, Mathilde Foglierini, Federico Mele, Rana Abdelnabi, Birgit Weynand, Julia Noack, Martin Montiel-Ruiz, Siro Bianchi, Fabio Benigni, Nicole Sprugasci, Anshu Joshi, John E. Bowen, Cameron Stewart, Megi Rexhepaj, Alexandra C. Walls, David Jarrossay, Diego Morone, Philipp Paparoditis, Christian Garzoni, Paolo Ferrari, Alessandro Ceschi, Johan Neyts, Lisa A. Purcell, Gyorgy Snell, Davide Corti, Antonio Lanzavecchia, David Veesler, Federica Sallusto
Publikováno v:
Science. 377:735-742
The coronavirus spike glycoprotein attaches to host receptors and mediates viral fusion. Using a broad screening approach, we isolated seven monoclonal antibodies (mAbs) that bind to all human-infecting coronavirus spike proteins from severe acute re
Autor:
Matthew McCallum, Nadine Czudnochowski, Laura E. Rosen, Samantha K. Zepeda, John E. Bowen, Alexandra C. Walls, Kevin Hauser, Anshu Joshi, Cameron Stewart, Josh R. Dillen, Abigail E. Powell, Tristan I. Croll, Jay Nix, Herbert W. Virgin, Davide Corti, Gyorgy Snell, David Veesler
Publikováno v:
Science (New York, N.Y.), vol 375, iss 6583
Science
Science
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern evades antibody-mediated immunity that comes from vaccination or infection with earlier variants due to accumulation of numerous spike mutations. To understan
Autor:
Tyler N. Starr, Samantha K. Zepeda, Alexandra C. Walls, Allison J. Greaney, Sergey Alkhovsky, David Veesler, Jesse D. Bloom
Publikováno v:
Nature. 603:913-918
Two different sarbecoviruses have caused major human outbreaks in the past two decades1,2. Both of these sarbecoviruses, SARS-CoV-1 and SARS-CoV-2, engage ACE2 through the spike receptor-binding domain2–6. However, binding to ACE2 orthologues of hu
Autor:
John E. Bowen, Young-Jun Park, Cameron Stewart, Jack T. Brown, William K. Sharkey, Alexandra C. Walls, Anshu Joshi, Kaitlin R. Sprouse, Matthew McCallum, M. Alejandra Tortorici, Nicholas M. Franko, Jennifer K. Logue, Ignacio G. Mazzitelli, Annalee W. Nguyen, Rui P. Silva, Yimin Huang, Jun Siong Low, Josipa Jerak, Sasha W. Tiles, Kumail Ahmed, Asefa Shariq, Jennifer M. Dan, Zeli Zhang, Daniela Weiskopf, Alessandro Sette, Gyorgy Snell, Christine M. Posavad, Najeeha Talat Iqbal, Jorge Geffner, Alessandra Bandera, Andrea Gori, Federica Sallusto, Jennifer A. Maynard, Shane Crotty, Wesley C. Van Voorhis, Carlos Simmerling, Renata Grifantini, Helen Y. Chu, Davide Corti, David Veesler
Publikováno v:
Science Immunology, 7 (78)
Numerous safe and effective coronavirus disease 2019 vaccines have been developed worldwide that use various delivery technologies and engineering strategies. We show here that vaccines containing prefusion-stabilizing S mutations elicit antibody res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf2fccde0b0e427d8e4670b2fff9021d
https://hdl.handle.net/20.500.11850/596105
https://hdl.handle.net/20.500.11850/596105
Autor:
Antonio Lanzavecchia, Lisa A. Purcell, Young-Jun Park, Nuria Izquierdo-Useros, Siro Bianchi, Stefano Jaconi, Marcel Meury, Maria De Agostini, Exequiel Dellota, Davide Corti, Fabio Benigni, David Veesler, Amalio Telenti, Elisabetta Cameroni, Florian A. Lempp, Herbert W. Virgin, Júlia Vergara-Alert, Martin Montiel-Ruiz, Hannah Kaiser, Jiayi Zhou, Javier Martinez-Picado, Anshu Joshi, Julia Noack, Alexandra C. Walls, Leah Soriaga, John E. Bowen
Publikováno v:
Nature. 598:342-347
SARS-CoV-2 infection—which involves both cell attachment and membrane fusion—relies on the angiotensin-converting enzyme 2 (ACE2) receptor, which is paradoxically found at low levels in the respiratory tract1–3, suggesting that there may be add