Zobrazeno 1 - 10
of 282
pro vyhledávání: '"Alexandra C, Newton"'
Autor:
Gema Lordén, Jacob M. Wozniak, Kim Doré, Lara E. Dozier, Chelsea Cates-Gatto, Gentry N. Patrick, David J. Gonzalez, Amanda J. Roberts, Rudolph E. Tanzi, Alexandra C. Newton
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Mutations that enhance the activity of protein kinase C alpha (PKCα) are associated with Alzheimer’s Disease. Here, the authors report that the enhanced activity of one variant, PKCα M489V, is sufficient to rewire the brain phosphoproteome, drive
Externí odkaz:
https://doaj.org/article/f626c5ecba534cfcaa1608a36cecb5d0
Autor:
Caila A. Pilo, Alexandra C. Newton
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Protein kinase C (PKC) isozymes transduce myriad signals within the cell in response to the generation of second messengers from membrane phospholipids. The conventional isozyme PKCγ reversibly binds Ca2+ and diacylglycerol, which leads to an open,
Externí odkaz:
https://doaj.org/article/d0c80aa759b74b0ab3bc359c09b0f423
Autor:
Xin Zhou, Yanghao Zhong, Olivia Molinar-Inglis, Maya T. Kunkel, Mingyuan Chen, Tengqian Sun, Jiao Zhang, John Y.-J. Shyy, JoAnn Trejo, Alexandra C. Newton, Jin Zhang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The role of mTORC1 at the lysosome is well established, but mTORC1 is known to be active in other cellular locations. Here, the authors develop Akt-STOPS to inhibit Akt specifically in the nucleus and identify a new regulatory mode for mTORC1 distinc
Externí odkaz:
https://doaj.org/article/328e1750a1694424bd2ac2b272c85bfe
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Hijacking the autophagic machinery is a key mechanism through which invasive pathogens such as Staphylococcus aureus replicate in their host cells. We have previously demonstrated that the bacteria replicate in phagosomes labeled with the autophagic
Externí odkaz:
https://doaj.org/article/2aff9979669a4c1bb7586b90930b9b19
Autor:
Hannah Tovell, Alexandra C. Newton
Publikováno v:
Biochemical Journal. 480:219-223
Allosteric regulation of multi-domain protein kinases provides a common mechanism to acutely control kinase activity. Protein kinase C serves as a paradigm for multi-domain proteins whose activity is exquisitely tuned by interdomain conformational ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93b7e4a312b8ac6d24dfec6a38e55f7f
https://doi.org/10.1042/bcj20220507
https://doi.org/10.1042/bcj20220507
Autor:
Ksenya Cohen Katsenelson, Joshua D Stender, Agnieszka T Kawashima, Gema Lordén, Satoshi Uchiyama, Victor Nizet, Christopher K Glass, Alexandra C Newton
Publikováno v:
eLife, Vol 8 (2019)
Inflammation is an essential aspect of innate immunity but also contributes to diverse human diseases. Although much is known about the kinases that control inflammatory signaling, less is known about the opposing phosphatases. Here we report that de
Externí odkaz:
https://doaj.org/article/a2603861948642c48bd8b12f43110840
Autor:
Li Gu, Yahui Zhu, Kosuke Watari, Maiya Lee, Junlai Liu, Sofia Perez, Melinda Thai, Joshua E. Mayfield, Bichen Zhang, Karina Cunha e Rocha, Fuming Li, Laura C. Kim, Alexander C. Jones, Igor H. Wierzbicki, Xiao Liu, Alexandra C. Newton, Tatiana Kisseleva, Jun Hee Lee, Wei Ying, David J. Gonzalez, Alan R. Saltiel, M. Celeste Simon, Michael Karin
Publikováno v:
Cell Metabolism.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00e8d8a54295dcaa500ab3e53d8a2e5b
https://doi.org/10.1016/j.cmet.2023.03.021
https://doi.org/10.1016/j.cmet.2023.03.021
Autor:
Timothy R. Baffi, Alexandra C. Newton
Publikováno v:
Trends in Biochemical Sciences. 47:518-530
Protein kinase C (PKC) isozymes are maintained in a 'ready-to-go' but 'safe' autoinhibited conformation until second messenger binding unleashes an autoinhibitory pseudosubstrate to allow substrate phosphorylation. However, to gain this 'ready-to-go'
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da5e15062e056af0e21c2dcc97852040
https://doi.org/10.1016/j.tibs.2022.03.003
https://doi.org/10.1016/j.tibs.2022.03.003
Autor:
Alexander C. Jones, Alexandr P. Kornev, Jui-Hung Weng, Gerard Manning, Susan S. Taylor, Alexandra C. Newton
Publikováno v:
bioRxiv
Conventional protein kinase C (PKC) isozymes tune the signaling output of cells, with loss-of-function somatic mutations associated with cancer and gain-of-function germline mutations identified in neurodegeneration. PKC with impaired autoinhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa4c80e72f6f9459a21a7f12be44d61
https://doi.org/10.1101/2023.03.16.532226
https://doi.org/10.1101/2023.03.16.532226
Autor:
Corina E. Antal, Julia A. Callender, Alexandr P. Kornev, Susan S. Taylor, Alexandra C. Newton
Publikováno v:
Cell Reports, Vol 12, Iss 8, Pp 1252-1260 (2015)
The signaling output of protein kinase C (PKC) is exquisitely controlled, with its disruption resulting in pathophysiologies. Identifying the structural basis for autoinhibition is central to developing effective therapies for cancer, where PKC activ
Externí odkaz:
https://doaj.org/article/c650f394c8d446f09707acf389c72e84