Muscle specific versus ubiquitous expression of Gag based HIV-1 DNA vaccines: a comparative analysis

Autor: Diana Hammer, Ralf Wagner, Alexandra Bojak, Hans Wolf

Publikováno v: Vaccine. 20:1975-1979

Most studies on DNA-based immunization have used viral promoters to drive antigen expression. In this study, we analyzed the properties of the commonly used CMV promoter, the tissue specific murine muscle creatine kinase (MCK) promoter as well as a h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2702005b5d5282d50e8aa5b8e13b252e
https://doi.org/10.1016/s0264-410x(02)00081-6

Contents Vol. 45, 2002

Autor: Colin R. Howard, A. Chatterji, Åke Lundkvist, Shereen El Kholy, C. Porta, A. Žvirblienė, Andrea Jegerlehner, Rolf E. Streeck, Stephen Norley, T. Lin, Peter Öhlschläger, Christian Pitra, Jeremy C. Simpson, Detlev H. Krüger, Patrik Maurer, Jörg Reimann, J. Staniulis, Reinhard Kurth, Matthias T. Dittmar, Matti Sällberg, Andris Kazaks, Jonas Kneser, Sylvie Lachmann, Carol A. Roneker, Brent E. Korba, G.P. Lomonossoff, Brian Hjelle, Andris Dislers, L.L. Burns, Eva-Jasmin Freyschmidt, Petra Riedl, Alain Tissot, David R. Milich, Hae-Wol Cho, Marcin Kwissa, Michael Nassal, D.W.G. Brown, J.E. Johnson, S. Süle, James Brooke Murray, Volker Bruss, A. Hale, Angela Rösen-Wolff, K. Sasnauskas, J. Michael Lord, Maurice R. Hilleman, Oliver Hohn, Diana Koletzki, R. Ulrich, Heidrun Guthöhrlein, Brigitte Beer, Wolfram Osen, Ivars Petrovskis, Shahryar Khattak, Lutz Gissmann, Franziska Lechner, Reinhold Schirmbeck, Gary T. Jennings, Hans Gelderblom, W.A. Knowles, A. Dargevičiūte, Jens Wild, Wolfgang A. Renner, Peter G. Stockley, Helga Meisel, Paul J. Cote, Ronald K. Potkul, W. Martin Kast, Velta Ose, Tom R. Phillips, D. Bartkevičiūte, Janice Hughes, Min Wu, Martin F. Bachmann, Peter Sebbel, Erik Seibold, Rainer G. Ulrich, S.S. Taylor, Doris Binninger-Schinzel, Ludwig Deml, Andrew W. Taylor-Robinson, Martin Müller, Paul Pumpens, Chris J. Adams, Ralf Wagner, Hans-Georg Kräusslich, Andreas M. Kaufmann, Robert Allan Mastico, Dörte Radke, Alexandra Bojak, Christophe Hourioux, Ulrich Marcus, Karen G. Heal, Joyce Jones, Mark T. Wakabayashi, Elmars Grens, Corina Cosma, L. Jin, George P. Lomonossoff, Dace Skrastina, Ho-Wang Lee, Stephan Menne, Galina Borisova, Bud C. Tennant, Diane M. Da Silva, William L. Brown, A. Bulavaite, Gholamreza Darai, Thorsten U. Vogel, Nico Michel, John L. Gerin, A. Gedvilaite

Publikováno v: Intervirology. 45:387-389

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ddc9c5708247dd1a35fde974cf4cb774
https://doi.org/10.1159/000069063

Impact of codon usage modification on T cell immunogenicity and longevity of HIV-1 gag-specific DNA vaccines

Autor: Ralf Wagner, Ludwig Deml, Jens Wild, Alexandra Bojak

Publikováno v: Intervirology. 45(4-6)

In this study, we analyzed the in vitro expression, potency and longevity of immune responses induced in a Balb/c mouse model by a synthetic HIV-1 gag gene exhibiting a codon usage that was adapted to that of highly expressed mammalian genes (syngag)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2d8f83d3c250862dd2d5c8675282c5
https://pubmed.ncbi.nlm.nih.gov/12566710

The past, present and future of HIV-vaccine development: a critical view

Autor: Ludwig Deml, Alexandra Bojak, Ralf Wagner

Publikováno v: Drug discovery today. 7(1)

Despite the extensive efforts that have been made to combat AIDS, the global number of HIV-1 infections is still increasing. There is major consent among scientists worldwide, that the development of successful HIV vaccine strategies requires a profo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf388f4419724e44df61b220c43646c
https://pubmed.ncbi.nlm.nih.gov/11790602

Erratum to 'Influence of polypeptide size and intracellular sorting on the induction of epitope-specific CTL responses by DNA vaccines in a mouse model' [Vaccine 22 (2004) 1732–1743]

Autor: Ralf Wagner, Jens Wild, Alexandra Bojak, Ludwig Deml

Publikováno v: Vaccine. 22:4132-4133

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f2acb58041392c77bebf79f23207e59
https://doi.org/10.1016/j.vaccine.2004.07.004