Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Alexandra Bick"'
Autor:
Willem Buys, Alexandra Bick, Rabea J. Madel, Astrid M. Westendorf, Jan Buer, Frank Herbstreit, Carsten J. Kirschning, Jürgen Peters
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionEarly sepsis is a life-threatening immune dysregulation believed to feature a “cytokine storm” due to activation of pattern recognition receptors by pathogen and danger associated molecular patterns. However, treatments with single to
Externí odkaz:
https://doaj.org/article/0f6bd744994d4ebcab332f1c92080099
Autor:
Linda E. Cox, Kai Walstein, Lena Völlger, Friederike Reuner, Alexandra Bick, Annika Dötsch, Andrea Engler, Jürgen Peters, Maren von Köckritz-Blickwede, Simon T. Schäfer
Publikováno v:
BMC Anesthesiology, Vol 20, Iss 1, Pp 1-9 (2020)
Abstract Background There is little knowledge, whether in patients with sepsis neutrophil extracellular trap (NET) formation and NET degrading nuclease activity are altered. Thus, we tested the hypotheses that 1) NET formation from neutrophils of sep
Externí odkaz:
https://doaj.org/article/a9e95e84342c4822aab23297fcb152e2
Autor:
Alexandra Bick, Willem Buys, Andrea Engler, Rabea Madel, Mazen Atia, Francesca Faro, Astrid M Westendorf, Andreas Limmer, Jan Buer, Frank Herbstreit, Carsten J Kirschning, Jürgen Peters
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0273247 (2022)
RationaleThe immune profile of sepsis patients is incompletely understood and hyperinflammation and hypoinflammation may occur concurrently or sequentially. Immune checkpoint inhibition (ICI) may counter hypoinflammation but effects are uncertain. We
Externí odkaz:
https://doaj.org/article/6ea8ff6976ca474f997f552712c7e3fe
Autor:
Linda Cox, Kai Walstein, Lena Völlger, Friederike Reuner, Alexandra Bick, Annika Dötsch, Andrea Engler, Jürgen Peters, Maren von Köckritz-Blickwede, Simon T. Schäfer
Publikováno v:
BMC Anesthesiology
BMC Anesthesiology, Vol 20, Iss 1, Pp 1-9 (2020)
BMC Anesthesiology, Vol 20, Iss 1, Pp 1-9 (2020)
Background: There is little knowledge, whether in patients with sepsis neutrophil extracellular trap (NET) formation and NET degrading nuclease activity are altered. Thus, we tested the hypotheses that 1) NET formation from neutrophils of septic pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed85df836e1b186271efa12abdb5475e
https://duepublico2.uni-due.de/receive/duepublico_mods_00071666
https://duepublico2.uni-due.de/receive/duepublico_mods_00071666
Autor:
Nathalie M. Malewicz, Astrid M. Westendorf, Monika Lindemann, Simon T. Schäfer, Kai Walstein, Jürgen Peters, Torsten Heine, Annika Dötsch, Peter A. Horn, Linda Cox, Andrea Engler, Alexandra Bick
Critically ill patients are at risk for sepsis, and immunosuppressive mechanisms may prevail. Whether functional tests are helpful to detect immune alterations is largely unknown. Therefore, we tested the hypotheses that reactivity of peripheral bloo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a098a2bf56cf0d1ba4c888aa232a682
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85075814242
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85075814242
Autor:
Schäfer, Annika Dötsch, Lewin Eisele, Miriam Rabeling, Katharina Rump, Kai Walstein, Alexandra Bick, Linda Cox, Andrea Engler, Hagen Bachmann, Karl-Heinz Jöckel, Michael Adamzik, Jürgen Peters, Simon
Publikováno v:
International Journal of Molecular Sciences; Volume 18; Issue 6; Pages: 1266
Hypoxia-inducible-factor-2α (HIF-2α) and HIF-2 degrading prolyl-hydroxylases (PHD) are key regulators of adaptive hypoxic responses i.e., in acute respiratory distress syndrome (ARDS). Specifically, functionally active genetic variants of HIF-2α (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::fed9f859689e562707e60dd022f9d515
Autor:
Annika Dötsch, Lewin Eisele, Miriam Rabeling, Katharina Rump, Kai Walstein, Alexandra Bick, Linda Cox, Andrea Engler, Hagen S. Bachmann, Karl-Heinz Jöckel, Michael Adamzik, Jürgen Peters, Simon T. Schäfer
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 18, Iss 6, p 1266 (2017)
International Journal of Molecular Sciences, Vol 18, Iss 6, p 1266 (2017)
Hypoxia-inducible-factor-2α (HIF-2α) and HIF-2 degrading prolyl-hydroxylases (PHD) are key regulators of adaptive hypoxic responses i.e., in acute respiratory distress syndrome (ARDS). Specifically, functionally active genetic variants of HIF-2α (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8f1def363c60637c892d341be1d38b26
https://pubmed.ncbi.nlm.nih.gov/28613249
https://pubmed.ncbi.nlm.nih.gov/28613249
Autor:
Joachim Fandrey, Jürgen Peters, Michael Adamzik, Simon T. Schäfer, Paktis Roshangar, Stilla Frede, Alexandra Bick, Sandra Winning
Publikováno v:
Anesthesiology. 118:1426-1436
Background: Hypoxia-inducible factor-1 (HIF-1) is a molecular key player in response to hypoxemic/inflammatory conditions prevailing in sepsis. In a prospective observational study, we tested the hypotheses that sepsis affects HIF-1α messenger ribon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db3b9610a25d13c7374d8b934cea0c96
https://doi.org/10.1097/aln.0b013e31828baa67
https://doi.org/10.1097/aln.0b013e31828baa67
Autor:
Annika, Höcker, Miriam, Rabeling, Alexandra, Bick, Linda, Cox, Maximiliane, Kreuzer, Andrea, Engler, Kai, Walstein, Hagen S, Bachmann, Karl-Heinz, Jöckel, Lewin, Eisele, Michael, Adamzik, Jürgen, Peters, Simon T, Schäfer
Publikováno v:
BMC Anesthesiology
Background Hypoxia-inducible-factor-1α (HIF-1α) and HIF-1 degrading prolyl-hydroxylases (PHD) are key regulators of the hypoxic-inflammatory response. Functionally active genetic variants in the HIF-1α (C/T; Single Nucleotide Polymorphism (SNP) rs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::08b3412187e012caa2a7629e9d71e313
https://pubmed.ncbi.nlm.nih.gov/27515179
https://pubmed.ncbi.nlm.nih.gov/27515179
Autor:
Simon T. Schäfer, Paktis Roshangar, Alexandra Bick, Sandra Winning, Jürgen Peters, Joachim Fandrey, Stilla Frede, Michael Adamzik
Publikováno v:
Survey of Anesthesiology. 58:106-107
Background Hypoxia-inducible factor-1 (HIF-1) is a molecular key player in response to hypoxemic/inflammatory conditions prevailing in sepsis. In a prospective observational study, we tested the hypotheses that sepsis affects HIF-1α messenger ribonu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53863d4a89f017af2dda83313134a318
https://doi.org/10.1097/01.sa.0000446364.03792.74
https://doi.org/10.1097/01.sa.0000446364.03792.74