Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Alexandra Bernlind"'
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 55:393-399
The myeloperoxidase (MPO) inhibitors 1 and 2 were prepared as their isotopologues with carbon-14, carbon-13, and nitrogen-15 or tritium with high specific activity and purity. Starting from potassium [14C]cyanide or [14C]formate provided metabolicall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f09c26d64f838c9097b1d0564f431670
https://doi.org/10.1002/jlcr.2961
https://doi.org/10.1002/jlcr.2961
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 55:80-83
The γ-secretase inhibitor dibenzazepine (DBZ) and the γ-secretase modulators 1 and AZ8349 were prepared as tritium-labeled compounds with high specific activity and radiochemical purity. [3H]DBZ was labeled via an iodinated precursor, [3H]1 was lab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::287818795edac14801922886f275c1e6
https://doi.org/10.1002/jlcr.1955
https://doi.org/10.1002/jlcr.1955
Autor:
Anna-Karin Tidén, Stefan Lundquist, Louisa V. Forbes, Nicholas J. Magon, Guy N. L. Jameson, Henrietta Norman, Staffan Schmidt, Alexandra Bernlind, Françoise Auchère, Susanne Gustavsson, Mats Svensson, Anthony J. Kettle, Revathy Senthilmohan, Per-Olof Markgren, Louise N. Paton, Tove Sjögren, Håkan Eriksson
Publikováno v:
Journal of Biological Chemistry. 286:37578-37589
Myeloperoxidase (MPO) is a prime candidate for promoting oxidative stress during inflammation. This abundant enzyme of neutrophils uses hydrogen peroxide to oxidize chloride to highly reactive and toxic chlorine bleach. We have identified 2-thioxanth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80ea56a092699fcfee3c626d7915cca1
https://doi.org/10.1074/jbc.m111.266981
https://doi.org/10.1074/jbc.m111.266981
Publikováno v:
Journal of labelled compoundsradiopharmaceuticals. 56(9-10)
A method for the preparation of [3'-(3) H]-4-(2'-chloro-6'-hydroxyphenyl)-2-thioxo-3,4-dihydro-1H-indeno[1,2-d]pyrimidin-5(2H)-one (1), a TRPA1 inhibitor, was developed for the evaluation of imaging properties of a class of TRPA1 inhibitors. 1 was pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b8d4d454df074951f793d1263eeaa72f
https://pubmed.ncbi.nlm.nih.gov/24285533
https://pubmed.ncbi.nlm.nih.gov/24285533
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals.
A method for the preparation of [2,3,4-3H]BMS299897 has been developed. The methyl ester of BMS299897 was oxidized to its double bond derivative, via a phenyl selenide. The resulting double bond was reduced with tritium using Wilkinson's catalyst. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e85b2910bbf6c09f4b380ccd73c8871
https://doi.org/10.1002/jlcr.1719
https://doi.org/10.1002/jlcr.1719
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 56:536-537
A method for the preparation of [3′-3H]-4-(2′-chloro-6′-hydroxyphenyl)-2-thioxo-3,4-dihydro-1H-indeno[1,2-d]pyrimidin-5(2H)-one (1), a TRPA1 inhibitor, was developed for the evaluation of imaging properties of a class of TRPA1 inhibitors. 1 was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fd047f2b637e92e495cac54faf5a077
https://doi.org/10.1002/jlcr.3030
https://doi.org/10.1002/jlcr.3030
Autor:
Per H. Svensson, Satish Srinivas Kitambi, Patrik Ernfors, Rune Ringom, Alexandra Bernlind, David Wennman, Mikael Granath, Lars Hammarström, Robert K. Harmel, Ylva Gravenfors, Fredrik Lehmann, Ylva Roddis, Katarina Färnegårdh, Göran Lundin
Publikováno v:
Journal of Medicinal Chemistry
Glioblastoma remains an incurable brain cancer. Drugs developed in the past 20 years have not improved the prognosis for patients, necessitating the development of new treatments. We have previously reported the therapeutic potential of the quinoline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff09203c2f0fd3f9f34cf8c5f7bab3e7