Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Alexandra Bernardo-Colón"'
Autor:
Alexandra Bernardo-Colón, Lijin Dong, Mones Abu-Asab, Richard S. Brush, Martin-Paul Agbaga, S. Patricia Becerra
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 5, Pp 100358- (2023)
Photoreceptor cells express the patatin-like phospholipase domain-containing 2 (PNPLA2) gene that codes for pigment epithelium-derived factor receptor (PEDF-R) (also known as ATGL). PEDF-R exhibits phospholipase activity that mediates the neurotrophi
Externí odkaz:
https://doaj.org/article/e6edfbfcaeb9463cb8396dbeb2decb19
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Retinal and choroidal inflammatory lesions increase the levels of the pro-inflammatory cytokine interleukin-6 (IL-6). Pigment epithelium-derived factor (PEDF) has anti-inflammatory properties, but it is not known if it can prevent the production of I
Externí odkaz:
https://doaj.org/article/83d777ab535646b0b164fe11e7a88838
Autor:
Chloe N. Thomas, Alexandra Bernardo-Colón, Ella Courtie, Gareth Essex, Tonia S. Rex, Richard J. Blanch, Zubair Ahmed
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Ocular repeated air blast injuries occur from low overpressure blast wave exposure, which are often repeated and in quick succession. We have shown that caspase-2 caused the death of retinal ganglion cells (RGC) after blunt ocular trauma. He
Externí odkaz:
https://doaj.org/article/5b1afdd3ed344166bd25ff7af7659085
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss , Pp 139-148 (2020)
The power of CRISPRi to decrease targeted gene expression for clinical applications has been inhibited by delivery challenges. Existing constructs are too large to fit within the ∼4.7 kb packaging size limitation of adeno-associated virus (AAV), th
Externí odkaz:
https://doaj.org/article/e62d5d2d855a481eac4ae831ee2cf1cb
Publikováno v:
Neurobiology of Disease, Vol 134, Iss , Pp - (2020)
Our goal was to investigate the neuroprotective effects of galantamine in a mouse model of blast-induced indirect traumatic optic neuropathy (bITON). Galantamine is an FDA-approved acetylcholinesterase inhibitor used to treat mild-moderate Alzheimer'
Externí odkaz:
https://doaj.org/article/804a7522fff24b79b726440a94f10209
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10, p 5344 (2021)
Retinoprotective proteins play important roles for retinal tissue integrity. They can directly affect the function and the survival of photoreceptors, and/or indirectly target the retinal pigment epithelium (RPE) and endothelial cells that support th
Externí odkaz:
https://doaj.org/article/de8f0b4cc5be4287868cf385f4f9a48a
Autor:
Alexandra Bernardo-Colón, Victoria Vest, Melissa L. Cooper, Sarah A. Naguib, David J. Calkins, Tonia S. Rex
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Indirect traumatic optic neuropathy (ITON) is a condition that is often associated with traumatic brain injury and can result in significant vision loss due to degeneration of retinal ganglion cell (RGC) axons at the time of injury or within the ensu
Externí odkaz:
https://doaj.org/article/79ead76cd86d48029e469df5ecae02ab
Autor:
Gareth Essex, Alexandra Bernardo-Colón, Tonia S. Rex, Zubair Ahmed, Richard J Blanch, Chloe N. Thomas, Ella Courtie
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
Ocular repeated air blast injuries occur from low overpressure blast wave exposure, which are often repeated and in quick succession. We have shown that caspase-2 caused the death of retinal ganglion cells (RGC) after blunt ocular trauma. Here, we in
Publikováno v:
The FASEB Journal. 36
Autor:
Sarah Naguib, Mukesh K. Gupta, Carlisle DeJulius, Alexandra Bernardo-Colón, Taylor E. Kavanaugh, Jon R. Backstrom, Tonia S. Rex, Craig L. Duvall
Publikováno v:
J Control Release
Wild-type erythropoietin (EPO) is promising for neuroprotection, but its therapeutic use is limited because it causes a systemic rise in hematocrit. We have developed an EPO-R76E derivative that maintains neuroprotective function without effects on h