Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Alexandra Badea"'
Autor:
Rohan Nadkarni, Zay Yar Han, Robert J Anderson, Alex J Allphin, Darin P Clark, Alexandra Badea, Cristian T Badea
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0303288 (2024)
BackgroundBrain region segmentation and morphometry in humanized apolipoprotein E (APOE) mouse models with a human NOS2 background (HN) contribute to Alzheimer's disease (AD) research by demonstrating how various risk factors affect the brain. Photon
Externí odkaz:
https://doaj.org/article/d4e74ba18b244235b08cd7e48428e2f1
Autor:
Seth T. Gammon, Allison S. Cohen, Adrienne L. Lehnert, Daniel C. Sullivan, Dariya Malyarenko, Henry Charles Manning, David A. Hormuth, Heike E. Daldrup-Link, Hongyu An, James D. Quirk, Kooresh Shoghi, Mark David Pagel, Paul E. Kinahan, Robert S. Miyaoka, A. McGarry Houghton, Michael T. Lewis, Peder Larson, Renuka Sriram, Stephanie J. Blocker, Stephen Pickup, Alexandra Badea, Cristian T. Badea, Thomas E. Yankeelov, Thomas L. Chenevert
Publikováno v:
Tomography, Vol 9, Iss 2, Pp 750-758 (2023)
Providing method descriptions that are more detailed than currently available in typical peer reviewed journals has been identified as an actionable area for improvement. In the biochemical and cell biology space, this need has been met through the c
Externí odkaz:
https://doaj.org/article/987d12f93c464f0385e654e3a94d2678
Publikováno v:
Stats, Vol 5, Iss 4, Pp 948-969 (2022)
In this paper, we propose a bivariate extension of univariate composite (two-spliced) distributions defined by a bivariate Pareto distribution for values larger than some thresholds and by a bivariate Gumbel distribution on the complementary domain.
Externí odkaz:
https://doaj.org/article/74aa2c928cce4f8d8e3ec79231a01157
Autor:
Jacques A. Stout, Ali Mahzarnia, Rui Dai, Robert J. Anderson, Scott Cousins, Jie Zhuang, Eleonora M. Lad, Diane B. Whitaker, David J. Madden, Guy G. Potter, Heather E. Whitson, Alexandra Badea
Publikováno v:
Biomedicines, Vol 12, Iss 1, p 147 (2024)
Age-related macular degeneration (AMD) has recently been linked to cognitive impairment. We hypothesized that AMD modifies the brain aging trajectory, and we conducted a longitudinal diffusion MRI study on 40 participants (20 with AMD and 20 controls
Externí odkaz:
https://doaj.org/article/77398214e77240b9a1080cc9f8a87bc5
Autor:
Alex J Allphin, Ali Mahzarnia, Darin P Clark, Yi Qi, Zay Y Han, Prajwal Bhandari, Ketan B Ghaghada, Alexandra Badea, Cristian T Badea
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0291733 (2023)
BackgroundCardiovascular disease (CVD) is associated with the apolipoprotein E (APOE) gene and lipid metabolism. This study aimed to develop an imaging-based pipeline to comprehensively assess cardiac structure and function in mouse models expressing
Externí odkaz:
https://doaj.org/article/768e4b5423604938a362b839e745ecfc
Autor:
Alexandra Badea, Didong Li, Andrei R. Niculescu, Robert J. Anderson, Jacques A. Stout, Christina L. Williams, Carol A. Colton, Nobuyo Maeda, David B. Dunson
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Externí odkaz:
https://doaj.org/article/1dacade8043c412481ea0f4528a13431
Autor:
K. Saidas Nair, Chitrangda Srivastava, Robert V. Brown, Swanand Koli, Hélène Choquet, Hong Soon Kang, Yien-Ming Kuo, Sara A. Grimm, Caleb Sutherland, Alexandra Badea, G. Allan Johnson, Yin Zhao, Jie Yin, Kyoko Okamoto, Graham Clark, Terete Borrás, Gulab Zode, Krishnakumar Kizhatil, Subhabrata Chakrabarti, Simon W. M. John, Eric Jorgenson, Anton M. Jetten
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Dysfunction of the trabecular meshwork (TM) is the chief cause of elevated intraocular pressure, the major risk factor of glaucoma. Here, the authors identify the transcription factor, GLIS1, as a critical regulator of TM maintenance and intraocular
Externí odkaz:
https://doaj.org/article/1d13ccf102314720a834e165f6b1a62d
Autor:
Alexandra Badea, Didong Li, Andrei R. Niculescu, Robert J. Anderson, Jacques A. Stout, Christina L. Williams, Carol A. Colton, Nobuyo Maeda, David B. Dunson
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Spatial navigation and orientation are emerging as promising markers for altered cognition in prodromal Alzheimer’s disease, and even in cognitively normal individuals at risk for Alzheimer’s disease. The different APOE gene alleles confer variou
Externí odkaz:
https://doaj.org/article/a5632a24f40443a39db761658b010de1
Autor:
Jie Zhuang, David J. Madden, Priscila Cunha, Alexandra Badea, Simon W. Davis, Guy G. Potter, Eleonora M. Lad, Scott W. Cousins, Nan-Kuei Chen, Kala Allen, Abigail J. Maciejewski, Xuan Duong Fernandez, Michele T. Diaz, Heather E. Whitson
Publikováno v:
NeuroImage: Clinical, Vol 30, Iss , Pp 102594- (2021)
Age-related macular degeneration (AMD) is a common retina disease associated with cognitive impairment in older adults. The mechanism(s) that account for the link between AMD and cognitive decline remain unclear. Here we aim to shed light on this iss
Externí odkaz:
https://doaj.org/article/7a157163c7b740429d4ba986b29534f4
Autor:
Robert J. Anderson, Christopher M. Long, Evan D. Calabrese, Scott H. Robertson, G. Allan Johnson, Gary P. Cofer, Richard J. O'Brien, Alexandra Badea
Publikováno v:
Frontiers in Physics, Vol 8 (2020)
Network approaches provide sensitive biomarkers for neurological conditions, such as Alzheimer's disease (AD). Mouse models can help advance our understanding of underlying pathologies, by dissecting vulnerable circuits. While the mouse brain contain
Externí odkaz:
https://doaj.org/article/b6c62c3adcd04a21b8636dd8367f9675