Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Alexandra B. Pincus"'
Autor:
Alexandra B. Pincus, Samuel J. Huang, Katie M. Lebold, Ubaldo De La Torre, Becky J. Proskocil, Matthew G. Drake, Hiroyuki Nakai, Allison D. Fryer, David B. Jacoby
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract We report subpopulations of airway parasympathetic neurons expressing substance P, neuronal nitric oxide synthase, and tyrosine hydroxylase, highlighting unexplored heterogeneity in this population. These neurotransmitter-specific subpopulat
Externí odkaz:
https://doaj.org/article/82e9296bdbf147ce882dcf05e2ab00fe
Autor:
Katie M, Lebold, Matthew G, Drake, Alexandra B, Pincus, Aubrey B, Pierce, Allison D, Fryer, David B, Jacoby
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 67:89-98
Asthma is a heterogeneous inflammatory airway disease that develops in response to a combination of genetic predisposition and environmental exposures. Patients with asthma are grouped into phenotypes with shared clinical features and biomarker profi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c3f709e762c846279bcfacb1369646
https://doi.org/10.1165/rcmb.2021-0535oc
https://doi.org/10.1165/rcmb.2021-0535oc
Autor:
Katie M. Lebold, Madeline Cook, Alexandra B. Pincus, Kimberly A. Nevonen, Brett A. Davis, Lucia Carbone, Gina N. Calco, Allison D. Fryer, David B. Jacoby, Matthew G. Drake
Maternal asthma increases childhood asthma risk through multiple mechanisms including epigenetic regulation of asthma-associated genes. DNA methylation is one form of epigenetic regulation that is both inherited and modified by environmental exposure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f424ec2076d8b27f694b35efa14d6526
https://doi.org/10.1101/2022.01.25.477760
https://doi.org/10.1101/2022.01.25.477760
Publikováno v:
Neurosci Lett
Neural changes underly hyperresponsiveness in asthma and other airway diseases. Afferent sensory nerves, nerves within the brainstem, and efferent parasympathetic nerves all contribute to airway hyperresponsiveness. Inflammation plays a critical role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::553abacb8ef04d65465ca3283a91ee60
https://pubmed.ncbi.nlm.nih.gov/33667601
https://pubmed.ncbi.nlm.nih.gov/33667601
Publikováno v:
Airway cell biology and immunopathology.
Background: Studies of airway parasympathetic nerves have been limited by inability to stimulate specific populations of neurons. We undertook these studies to develop an optogenetic approach to stimulate airway parasympathetic neurons in vivo. Metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5292540d23446acf1ff86c59cb5cf8fb
https://doi.org/10.1183/13993003.congress-2019.pa5214
https://doi.org/10.1183/13993003.congress-2019.pa5214
Publikováno v:
Lung and airway developmental biology.
Background: Maternal asthma causes airway hyperreactivity in infants at birth and increases asthma risk in childhood. Humans with severe asthma have increased sensory nerve density in airways. Aim: We investigated whether maternal allergen exposure a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e440d6462409a01836d1918f4a57026a
https://doi.org/10.1183/13993003.congress-2018.pa1380
https://doi.org/10.1183/13993003.congress-2018.pa1380
Autor:
Katherine M. Lebold, Matthew G. Drake, Allison D. Fryer, Becky J. Proskocil, Zhenying Nie, David B. Jacoby, Emily D. Blum, Alexandra B. Pincus, Quinn R. Roth-Carter
Airway eosinophils are increased in asthma and are especially abundant around airway nerves. Nerves control bronchoconstiction and in asthma, airway hyperreactivity (where airways contract excessively to inhaled stimuli) develops when eosinophils alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de3443e9a060453eea1ce1b04d1b83c6
https://europepmc.org/articles/PMC6541210/
https://europepmc.org/articles/PMC6541210/
Autor:
Matthew G. Drake, David B. Jacoby, Alexandra B. Pincus, Katie Lebold, Allison D. Fryer, Nancy Y. Lee, James Lee
Publikováno v:
Allergy and immunology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4825e4d045c3da01f459de481288f45b
https://doi.org/10.1183/1393003.congress-2017.oa4851
https://doi.org/10.1183/1393003.congress-2017.oa4851