Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Alexandra B. Forman"'
Autor:
Clare F. Malone, Minjee Kim, Gabriela Alexe, Kathleen Engel, Alexandra B. Forman, Amanda Robichaud, Amy Saur Conway, Amy Goodale, Ashleigh Meyer, Delan Khalid, Allen Thayakumar, John M. Hatcher, Nathanael S. Gray, Federica Piccioni, Kimberly Stegmaier
Publikováno v:
Cancer Research. 83:285-300
Aberrant RAS/MAPK signaling is a common driver of oncogenesis that can be therapeutically targeted with clinically approved MEK inhibitors. Disease progression on single-agent MEK inhibitors is common, however, and combination therapies are typically
Autor:
Kimberly Stegmaier, Francisca Vazquez, Todd R. Golub, David E. Root, Scott T. Younger, Joseph D. Mancias, Volker Hovestadt, Nancy Dumont, Brenton R. Paolella, Joshua M. Dempster, Amy Saur Conway, Amanda L. Robichaud, Miljan Kuljanin, Alfredo Gonzalez, Mai Abdusamad, Michael V. Rothberg, Alexandra B. Forman, Guillaume Kugener, Neekesh V. Dharia, Clare F. Malone
NXT2 expression is associated with NXT1 dependency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b3b0cf92ac2514acd3f0a02dca1932
https://doi.org/10.1158/2159-8290.22539455.v1
https://doi.org/10.1158/2159-8290.22539455.v1
Autor:
Kimberly Stegmaier, Francisca Vazquez, Todd R. Golub, David E. Root, Scott T. Younger, Joseph D. Mancias, Volker Hovestadt, Nancy Dumont, Brenton R. Paolella, Joshua M. Dempster, Amy Saur Conway, Amanda L. Robichaud, Miljan Kuljanin, Alfredo Gonzalez, Mai Abdusamad, Michael V. Rothberg, Alexandra B. Forman, Guillaume Kugener, Neekesh V. Dharia, Clare F. Malone
CRISPR guide sequences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f5c15a72ce13e9594b29f8a9df403d
https://doi.org/10.1158/2159-8290.22539446.v1
https://doi.org/10.1158/2159-8290.22539446.v1
Autor:
Kimberly Stegmaier, Francisca Vazquez, Todd R. Golub, David E. Root, Scott T. Younger, Joseph D. Mancias, Volker Hovestadt, Nancy Dumont, Brenton R. Paolella, Joshua M. Dempster, Amy Saur Conway, Amanda L. Robichaud, Miljan Kuljanin, Alfredo Gonzalez, Mai Abdusamad, Michael V. Rothberg, Alexandra B. Forman, Guillaume Kugener, Neekesh V. Dharia, Clare F. Malone
Differential NXT2 expression in neuroblastoma cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48596ce6d85a7becb6ded4f53a2dd34a
https://doi.org/10.1158/2159-8290.22539452.v1
https://doi.org/10.1158/2159-8290.22539452.v1
Autor:
Kimberly Stegmaier, Francisca Vazquez, Todd R. Golub, David E. Root, Scott T. Younger, Joseph D. Mancias, Volker Hovestadt, Nancy Dumont, Brenton R. Paolella, Joshua M. Dempster, Amy Saur Conway, Amanda L. Robichaud, Miljan Kuljanin, Alfredo Gonzalez, Mai Abdusamad, Michael V. Rothberg, Alexandra B. Forman, Guillaume Kugener, Neekesh V. Dharia, Clare F. Malone
NXT1 is a selective and lethal dependency in neuroblastoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c007b460f4affa6e191fd02da49f312
https://doi.org/10.1158/2159-8290.22539461
https://doi.org/10.1158/2159-8290.22539461
Autor:
Kimberly Stegmaier, Francisca Vazquez, Todd R. Golub, David E. Root, Scott T. Younger, Joseph D. Mancias, Volker Hovestadt, Nancy Dumont, Brenton R. Paolella, Joshua M. Dempster, Amy Saur Conway, Amanda L. Robichaud, Miljan Kuljanin, Alfredo Gonzalez, Mai Abdusamad, Michael V. Rothberg, Alexandra B. Forman, Guillaume Kugener, Neekesh V. Dharia, Clare F. Malone
NXT2 expression is not associated with neuroblastoma disease subtypes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9cf9888fe1dbf41f41b0f00cae68372
https://doi.org/10.1158/2159-8290.22539449
https://doi.org/10.1158/2159-8290.22539449
Autor:
Kimberly Stegmaier, Francisca Vazquez, Todd R. Golub, David E. Root, Scott T. Younger, Joseph D. Mancias, Volker Hovestadt, Nancy Dumont, Brenton R. Paolella, Joshua M. Dempster, Amy Saur Conway, Amanda L. Robichaud, Miljan Kuljanin, Alfredo Gonzalez, Mai Abdusamad, Michael V. Rothberg, Alexandra B. Forman, Guillaume Kugener, Neekesh V. Dharia, Clare F. Malone
CRISPR screens prioritize rapidly lethal in vivo relevant dependencies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1af877322b325280a79c0f7396f7b380
https://doi.org/10.1158/2159-8290.22539464.v1
https://doi.org/10.1158/2159-8290.22539464.v1
Autor:
Kimberly Stegmaier, Francisca Vazquez, Todd R. Golub, David E. Root, Scott T. Younger, Joseph D. Mancias, Volker Hovestadt, Nancy Dumont, Brenton R. Paolella, Joshua M. Dempster, Amy Saur Conway, Amanda L. Robichaud, Miljan Kuljanin, Alfredo Gonzalez, Mai Abdusamad, Michael V. Rothberg, Alexandra B. Forman, Guillaume Kugener, Neekesh V. Dharia, Clare F. Malone
NXT2 loss leads to loss of NXF1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::465ffef89586b08395587f60551eec44
https://doi.org/10.1158/2159-8290.22539458.v1
https://doi.org/10.1158/2159-8290.22539458.v1
Autor:
Kimberly Stegmaier, Francisca Vazquez, Todd R. Golub, David E. Root, Scott T. Younger, Joseph D. Mancias, Volker Hovestadt, Nancy Dumont, Brenton R. Paolella, Joshua M. Dempster, Amy Saur Conway, Amanda L. Robichaud, Miljan Kuljanin, Alfredo Gonzalez, Mai Abdusamad, Michael V. Rothberg, Alexandra B. Forman, Guillaume Kugener, Neekesh V. Dharia, Clare F. Malone
Cancer dependency maps, which use CRISPR/Cas9 depletion screens to profile the landscape of genetic dependencies in hundreds of cancer cell lines, have identified context-specific dependencies that could be therapeutically exploited. An ideal therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c0222ac2a2c6c22d60bba9034ffb48f
https://doi.org/10.1158/2159-8290.c.6549098.v1
https://doi.org/10.1158/2159-8290.c.6549098.v1
Autor:
Kimberly Stegmaier, Federica Piccioni, Nathanael S. Gray, John M. Hatcher, Allen Thayakumar, Delan Khalid, Ashleigh Meyer, Amy Goodale, Amy Saur Conway, Amanda Robichaud, Alexandra B. Forman, Kathleen Engel, Gabriela Alexe, Minjee Kim, Clare F. Malone
Supplemental Figures S1-S6 and Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8650dac4e203c2c17f3354686bcb280e
https://doi.org/10.1158/0008-5472.22432890.v1
https://doi.org/10.1158/0008-5472.22432890.v1