Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Alexandra B Nelson"'
Autor:
Jonathan S Schor, Isabelle Gonzalez Montalvo, Perry WE Spratt, Rea J Brakaj, Jasmine A Stansil, Emily L Twedell, Kevin J Bender, Alexandra B Nelson
Publikováno v:
eLife, Vol 11 (2022)
Subthalamic nucleus deep brain stimulation (STN DBS) relieves many motor symptoms of Parkinson’s disease (PD), but its underlying therapeutic mechanisms remain unclear. Since its advent, three major theories have been proposed: (1) DBS inhibits the
Externí odkaz:
https://doaj.org/article/666d2c4e2e3b44e798b540be83165200
Autor:
Michael B. Ryan, Allison E. Girasole, Andrew J. Flores, Emily L. Twedell, Matthew M. McGregor, Rea Brakaj, Ronald F. Paletzki, Thomas S. Hnasko, Charles R. Gerfen, Alexandra B. Nelson
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114483- (2024)
Summary: The striatum integrates dopaminergic and glutamatergic inputs to select preferred versus alternative actions. However, the precise mechanisms underlying this process remain unclear. One way to study action selection is to understand how it b
Externí odkaz:
https://doaj.org/article/825603252a4c4ae58da19f1e6899922c
Autor:
Yaisa Andrews-Zwilling, Anna K Gillespie, Alexxai V Kravitz, Alexandra B Nelson, Nino Devidze, Iris Lo, Seo Yeon Yoon, Nga Bien-Ly, Karen Ring, Daniel Zwilling, Gregory B Potter, John L R Rubenstein, Anatol C Kreitzer, Yadong Huang
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40555 (2012)
Although extensive research has demonstrated the importance of excitatory granule neurons in the dentate gyrus of the hippocampus in normal learning and memory and in the pathogenesis of amnesia in Alzheimer's disease (AD), the role of hilar GABAergi
Externí odkaz:
https://doaj.org/article/1f169e12eed84a99bcdef4bcb3aeb143
Autor:
Jingwen Yao, Melanie A. Morrison, Angela Jakary, Sivakami Avadiappan, Yicheng Chen, Johanna Luitjens, Julia Glueck, Theresa Driscoll, Michael D. Geschwind, Alexandra B. Nelson, Javier E. Villanueva-Meyer, Christopher P. Hess, Janine M. Lupo
Publikováno v:
NeuroImage, Vol 265, Iss , Pp 119788- (2023)
Quantitative susceptibility mapping (QSM) is a promising tool for investigating iron dysregulation in neurodegenerative diseases, including Huntington's disease (HD). Many diverse methods have been proposed to generate accurate and robust QSM images.
Externí odkaz:
https://doaj.org/article/a3391d4e1e5b428a868b35701d13743e
Autor:
Matthew M. McGregor, Gabriel L. McKinsey, Allison E. Girasole, Chloe J. Bair-Marshall, John L.R. Rubenstein, Alexandra B. Nelson
Publikováno v:
Cell Reports, Vol 29, Iss 6, Pp 1419-1428.e5 (2019)
Summary: One long-standing model of striatal function divides the striatum into compartments called striosome and matrix. While some anatomical evidence suggests that these populations represent distinct striatal pathways with differing inputs and ou
Externí odkaz:
https://doaj.org/article/9cd914ce656f4cc0ab1432dd66a315d0
Autor:
Michael B. Ryan, Allison E. Girasole, Matthew M. McGregor, Rea Brakaj, Ronald F. Paletzki, Charles R. Gerfen, Alexandra B. Nelson
The striatum integrates dopaminergic and glutamatergic inputs to select preferred versus alternative actions, but the precise mechanisms remain unclear. One way to study action selection is when it breaks down. Here, we explored the cellular and syna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8270c786bb83cf3367f1e0808a5ebacb
https://doi.org/10.1101/2022.10.31.514594
https://doi.org/10.1101/2022.10.31.514594
The S-Factor, a New Measure of Disease Severity in Spinocerebellar Ataxia: Findings and Implications
Autor:
Louisa P. Selvadurai, Susan L. Perlman, George R. Wilmot, Sub H. Subramony, Christopher M. Gomez, Tetsuo Ashizawa, Henry L. Paulson, Chiadi U. Onyike, Liana S. Rosenthal, Haris I. Sair, Sheng-Han Kuo, Eva-Maria Ratai, Theresa A. Zesiewicz, Khalaf O. Bushara, Gülin Öz, Cameron Dietiker, Michael D. Geschwind, Alexandra B. Nelson, Puneet Opal, Talene A. Yacoubian, Peggy C. Nopoulos, Vikram G. Shakkottai, Karla P. Figueroa, Stefan M. Pulst, Peter E. Morrison, Jeremy D. Schmahmann
Spinocerebellar ataxias (SCAs) are progressive neurodegenerative disorders, but there is no metric that predicts disease severity over time. We hypothesized that by developing a new metric, the Severity Factor (S-Factor) using immutable disease param
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d9f84d79ecb1e743ffa267784f9f2c4
https://escholarship.org/uc/item/798300bm
https://escholarship.org/uc/item/798300bm
Autor:
Jingwen Yao, Melanie A. Morrison, Angela Jakary, Sivakami Avadiappan, Yicheng Chen, Johanna Luitjens, Julia Glueck, Theresa Driscoll, Michael D. Geschwind, Alexandra B. Nelson, Javier E. Villanueva-Meyer, Christopher P. Hess, Janine M. Lupo
Publikováno v:
NeuroImage.
Quantitative susceptibility mapping (QSM) is a promising tool for investigating iron dysregulation in neurodegenerative diseases, including Huntington's disease (HD). A diverse range of methods have been proposed to generate accurate and robust QSM i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2acd954261f1d12bc2d6ebccc4536ee9
https://pubmed.ncbi.nlm.nih.gov/36476567
https://pubmed.ncbi.nlm.nih.gov/36476567
Autor:
Jonathan S Schor, Isabelle Gonzalez Montalvo, Perry WE Spratt, Rea J Brakaj, Jasmine A Stansil, Emily L Twedell, Kevin J Bender, Alexandra B Nelson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09b1000288eb46b79f7dcb965de3e71e
https://doi.org/10.7554/elife.75253.sa2
https://doi.org/10.7554/elife.75253.sa2
Autor:
Alexandra B. Nelson, Allison E. Girasole, Hsien-Yang Lee, Louis J. Ptáček, Anatol C. Kreitzer
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 42, iss 13
J Neurosci
J Neurosci
Abnormal involuntary movements, or dyskinesias, are seen in many neurologic diseases, including disorders where the brain appears grossly normal. This observation suggests that alterations in neural activity or connectivity may underlie dyskinesias.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e2d91998b2a614b7b42d64a63db4a1d
https://escholarship.org/uc/item/2916w3dt
https://escholarship.org/uc/item/2916w3dt