Quantitative CT imaging and radiation-absorbed dose estimations of 166Ho microspheres: paving the way for clinical application

Autor: Chiron Morsink, Nienke Klaassen, Gerrit van de Maat, Milou Boswinkel, Alexandra Arranja, Robin Bruggink, Ilva van Houwelingen, Irene Schaafsma, Jan Willem Hesselink, Frank Nijsen, Bas van Nimwegen

Publikováno v: European Radiology Experimental, Vol 8, Iss 1, Pp 1-17 (2024)

Abstract Background Microbrachytherapy enables high local tumor doses sparing surrounding tissues by intratumoral injection of radioactive holmium-166 microspheres (166Ho-MS). Magnetic resonance imaging (MRI) cannot properly detect high local Ho-MS c

Externí odkaz: https://doaj.org/article/7830881403b74f8a903d2e567f24bea3

Imaging-assisted hydrogel formation for single cell isolation

Autor: Serhii Mytnyk, Alexandra Arranja, Marcel de Puit, Jan H. van Esch, Sander Oldenhof

Publikováno v: Scientific Reports, 10(1)
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)

We report a flexible single-cell isolation method by imaging-assisted hydrogel formation. Our approach consists of imaging-aided selective capture of cells of interest by encasing them into a polymeric hydrogel, followed by removal of unwanted cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::999133b32289caaae98629801f1bdc38
http://resolver.tudelft.nl/uuid:85fa13e7-3a5a-4b99-8d94-abeebfcb9e60

Intravenous and intratumoral injection of Pluronic P94: The effect of administration route on biodistribution and tumor retention

Autor: Eduardo Mendes, Marion de Jong, Costanza Santini, F. Schosseler, Karolina Morawska, Monique R. Bernsen, Alexandra Arranja, Peter Dubruel, Antonia G. Denkova

Publikováno v: Nanomedicine: Nanotechnology, Biology and Medicine
Nanomedicine: Nanotechnology, Biology and Medicine, 2017, 13 (7), pp.2179-2188. ⟨10.1016/j.nano.2017.04.015⟩
Nanomedicine-Nanotechnology Biology and Medicine, 13(7), 2179-2188. Elsevier Inc.

International audience; Pluronics P94 are block-copolymer showing prolonged circulation time and tumor-cell internalization in vitro, suggesting a potential for tumor accumulation and as a drug carrier. Here we report the results of the radiolabeled-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09aa3884be66c27fe7e42b65e48f1711
https://doi.org/10.1016/j.nano.2017.04.015

Interactions of Pluronic nanocarriers with 2D and 3D cell cultures: Effects of PEO block length and aggregation state

Autor: Sandra Van Vlierberghe, Alexandra Arranja, Gilles Waton, Peter Dubruel, Antonia G. Denkova, Eduardo Mendes, Karolina Morawska, F. Schosseler

Publikováno v: Journal of Controlled Release. 224:126-135

This work reveals how the physicochemical properties of Pluronic block copolymers influence significantly their interactions with cancer cells, whether in monolayer or spheroid cultures, and how different clinical applications can be foreseen. Two-di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96f20f625c514cea8056381172f5d629
https://doi.org/10.1016/j.jconrel.2016.01.014

Fluorescent CSC models evidence that targeted nanomedicines improve treatment sensitivity of breast and colon cancer stem cells

Autor: Mafalda Videira, Ibane Abasolo, Núria Bergadà Fort, Diego Arango, Luis Pleno de Gouveia, Joan Sayos Ortega, Rafael Miñana Prieto, Alexandra Arranja, Petra Gener, Diana Rafael, Guillem Romero Sabat, Yolanda Fernández, Simó Schwartz

Publikováno v: Nanomedicine: Nanotechnology, Biology and Medicine. 11:1883-1892

To be able to study the efficacy of targeted nanomedicines in marginal population of highly aggressive cancer stem cells (CSC), we have developed a novel in vitro fluorescent CSC model that allows us to visualize these cells in heterogeneous populati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::349e9e03ff6d12e0cf470dbb767957d2
https://doi.org/10.1016/j.nano.2015.07.009