Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Alexandra Ambrico"'
Autor:
Adam Naguib, Grinu Mathew, Colleen R. Reczek, Kaitlin Watrud, Alexandra Ambrico, Tali Herzka, Irene Casanova Salas, Matthew F. Lee, Nour El-Amine, Wu Zheng, M. Emilia Di Francesco, Joseph R. Marszalek, Darryl J. Pappin, Navdeep S. Chandel, Lloyd C. Trotman
Publikováno v:
Cell Reports, Vol 23, Iss 1, Pp 58-67 (2018)
Summary: A hallmark of advanced prostate cancer (PC) is the concomitant loss of PTEN and p53 function. To selectively eliminate such cells, we screened cytotoxic compounds on Pten−/−;Trp53−/− fibroblasts and their Pten-WT reference. Highly se
Externí odkaz:
https://doaj.org/article/ef92114328e64222bc2c836f7460a8f4
Autor:
Lorna Wills, Saya H. Ebbesen, Wu Zheng, Navneet Narula, Scott Powers, Kendra S. Plafker, Lloyd C. Trotman, Tali Herzka, Brian D. Robinson, Kaitlin Watrud, Vivek Mittal, Brendon M. Stiles, Nasser K. Altorki, Carlos Stahlhut, Dawid G. Nowak, John E. Wilkinson, Abu Nasar, Raffaella Sordella, Matthias Minderer, Carlos Cordon-Cardo, Mireia Castillo-Martin, Martha E. Zeeman, Alexandra Ambrico, Muhan Chen, Victoria M.-Y. Wang, Scott M. Plafker
Publikováno v:
The Journal of Cell Biology
Reduced PTEN protein is linked to tumorigenesis. Here, Chen et al. show that the nuclear transport receptor Importin-11 separates PTEN from degradation machinery. IPO11 mutant mice exhibit PTEN degradation, lung adenocarcinoma, and prostate neoplasia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31477751c8156743578470802ad370b5
https://doi.org/10.1083/jcb.201604025
https://doi.org/10.1083/jcb.201604025
Autor:
Chun Gwon Park, Johannes T.-H. Yeh, David Ng, Lloyd C. Trotman, Mario A. Shields, Jean Albrengues, Ellese M. Carmona, Dale Uyeminami, Laura Maiorino, Mikala Egeblad, Phyllis A. Gimotty, Douglas T. Fearon, Priya Upadhyay, Victoria Küttner, Carmelita Bautista, Michael S. Goldberg, Kent E. Pinkerton, Emilis Bružas, Arnaud Pommier, Scott K. Lyons, Alexandra Ambrico, Morgan E. Poindexter, Kenneth Chang
Publikováno v:
Science (New York, N.Y.), vol 361, iss 6409
INTRODUCTION Most cancer patients die from cancer that recurs after spreading to a different tissue, rather than from their original tumor. After successful treatment of the original tumor, cancer cells that have disseminated to other sites can under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4540c6b7f30194a0a75ecc7747ba0dc4
https://escholarship.org/uc/item/07z534z0
https://escholarship.org/uc/item/07z534z0
Autor:
Lloyd C. Trotman, Irene Casanova-Salas, Dawid G. Nowak, Alexandra Ambrico, Kaitlin Watrud, Vincent D'Andrea
Publikováno v:
Cancer Research. 78:1097-1097
Prostate cancer (PC) is one of the most prevalent cancers among men, causing almost 30,000 deaths per year in the US alone. Death caused by PC is mainly due to metastasis, and the 5-year survival rate of metastatic PC is only 28%. In contrast, the 5-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::076aa5cc7939784704ef7cb1750f1425
https://doi.org/10.1158/1538-7445.am2018-1097
https://doi.org/10.1158/1538-7445.am2018-1097
Autor:
Lily C. Wang, Hyejin Cho, Lewis C. Cantley, Carlos Stahlhut, Lloyd C. Trotman, Kaitlin Watrud, Jun Qi, Alexandra Ambrico, James E. Bradner
Publikováno v:
Cancer Research. 76:4165-4165
We describe our efforts to determine the effect of MYC and PI3K inhibition in a genetically engineered mouse model of naïve and castration-resistant metastatic prostate cancer. Metastasis is a major driver of mortality and morbidity in prostate canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ded84b62c75de348e87a77a9316d2a17
https://doi.org/10.1158/1538-7445.am2016-4165
https://doi.org/10.1158/1538-7445.am2016-4165
Autor:
Lewis C. Cantley, Hyejin Cho, Lloyd C. Trotman, Carlos Stahlhut, Alexandra Ambrico, James E. Bradner, Lily C. Wang, Jun Qi, Kaitlin Watrud
Publikováno v:
Cancer Research. 75:2636-2636
Metastasis is a major driver of mortality and morbidity in prostate cancer, the most common cancer type in men and the second leading cause of cancer-related deaths in the western world. To recapitulate the process in genetically engineered mice, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5ede5bde1b0cff99b80228799906201
https://doi.org/10.1158/1538-7445.am2015-2636
https://doi.org/10.1158/1538-7445.am2015-2636