Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Alexandra Abos"'
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 5, Pp n/a-n/a (2024)
Abstract Accurate prediction of a new compound's pharmacokinetic (PK) profile is pivotal for the success of drug discovery programs. An initial assessment of PK in preclinical species and humans is typically performed through allometric scaling and m
Externí odkaz:
https://doaj.org/article/7895c398bbc04b57838d372fbbb73873
Publikováno v:
Frontiers in Systems Biology, Vol 3 (2023)
Prediction of a new molecule’s exposure in plasma is a critical first step toward understanding its efficacy/toxicity profile and concluding whether it is a possible first-in-class, best-in-class candidate. For this prediction, traditional pharmaco
Externí odkaz:
https://doaj.org/article/6a15d59481f444f890704204a16bd684
Autor:
Carme Uribe, Carme Junque, Esther Gómez-Gil, Alexandra Abos, Sven C. Mueller, Antonio Guillamon
Publikováno v:
Data in Brief, Vol 31, Iss , Pp 105691- (2020)
We provide T2*-weighted and T1-weighted images acquired on a 3T MRI scanner obtained from 17 transwomen and 29 transmen with gender incongruence; and 22 ciswomen and 19 cismen that identified themselves to the sex assigned at birth. Data from three d
Externí odkaz:
https://doaj.org/article/6370135ec4584244957bc5c09a2718b3
Autor:
Carme Uribe, Carme Junque, Esther Gómez-Gil, Alexandra Abos, Sven C. Mueller, Antonio Guillamon
Publikováno v:
NeuroImage, Vol 211, Iss , Pp 116613- (2020)
Functional brain organization in transgender persons remains unclear. Our aims were to investigate global and regional connectivity differences within functional networks in transwomen and transmen with early-in-life onset gender incongruence; and to
Externí odkaz:
https://doaj.org/article/56a55672735e40eb8d7098d0ec34cf35
Neuroanatomical and Functional Correlates of Cognitive and Affective Empathy in Young Healthy Adults
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 13 (2019)
Neural substrates of empathy are mainly investigated through task-related functional MRI. However, the functional neural mechanisms at rest underlying the empathic response have been poorly studied. We aimed to investigate neuroanatomical and functio
Externí odkaz:
https://doaj.org/article/6a29f31198a7415e88a58233dfb6efd3
Autor:
Anna Campabadal, Barbara Segura, Carme Junque, Monica Serradell, Alexandra Abos, Carme Uribe, Hugo C. Baggio, Carles Gaig, Joan Santamaria, Yaroslau Compta, Nuria Bargallo, Alex Iranzo
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
Objective: In this study we investigate cortical and subcortical gray matter structure in patients with Idiopathic REM-sleep behavior disorder (IRBD), and their relation to cognitive performance.Methods: This study includes a sample of 20 patients wi
Externí odkaz:
https://doaj.org/article/ce8938282e11436093bea9045073d79e
Autor:
Alexandra Abos, Barbara Segura, Hugo C. Baggio, Anna Campabadal, Carme Uribe, Alicia Garrido, Ana Camara, Esteban Muñoz, Francesc Valldeoriola, Maria Jose Marti, Carme Junque, Yaroslau Compta
Publikováno v:
NeuroImage: Clinical, Vol 23, Iss , Pp - (2019)
Background: Structural connectivity is a promising methodology to detect patterns of neural network dysfunction in neurodegenerative diseases. This approach has not been tested in progressive supranuclear palsy (PSP). Objectives: The aim of this stud
Externí odkaz:
https://doaj.org/article/3f0ac98415294268a76c440133d1e9ba
Autor:
Hugo C. Baggio, Alexandra Abos, Barbara Segura, Anna Campabadal, Carme Uribe, Darly M. Giraldo, Alexandra Perez-Soriano, Esteban Muñoz, Yaroslau Compta, Carme Junque, Maria Jose Marti
Publikováno v:
NeuroImage: Clinical, Vol 22, Iss , Pp - (2019)
Background: Recent studies using resting-state functional connectivity and machine-learning to distinguish patients with neurodegenerative diseases from other groups of subjects show promising results. This approach has not been tested to discriminat
Externí odkaz:
https://doaj.org/article/a512e65ad06e4ce19db6da3e350b8406
Autor:
Carme Uribe, Barbara Segura, Hugo C. Baggio, Anna Campabadal, Alexandra Abos, Yaroslau Compta, Maria Jose Marti, Francesc Valldeoriola, Nuria Bargallo, Carme Junque
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2018)
Hippocampal subfields have different vulnerability to the degenerative processes related to aging, amnestic mild cognitive impairment (MCI) and Alzheimer’s disease (AD), but the temporal evolution in Parkinson’s disease (PD) is unknown. The purpo
Externí odkaz:
https://doaj.org/article/ee80cb340d6145f0aab8d49217e491d7
Autor:
Carme Uribe, Barbara Segura, Hugo C. Baggio, Alexandra Abos, Anna I. Garcia-Diaz, Anna Campabadal, Maria J. Marti, Francesc Valldeoriola, Yaroslau Compta, Nuria Bargallo, Carme Junque
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2018)
Gray/white matter contrast (GWC) decreases with aging and has been found to be a useful MRI biomarker in Alzheimer’s disease (AD), but its utility in Parkinson’s disease (PD) patients has not been investigated. The aims of the study were to test
Externí odkaz:
https://doaj.org/article/86f5a3d6e2df4b508f583ffa34d8ca16