Mitochondrial Targeting of Amyloid-β Protein Precursor Intracellular Domain Induces Hippocampal Cell Death via a Mechanism Distinct from Amyloid-β

Autor: Alexandra A. Sandberg, Evan Manning, Heather M. Wilkins, Randall Mazzarino, Taylor Minckley, Russell H. Swerdlow, David Patterson, Yan Qin, Daniel A. Linseman

Publikováno v: Journal of Alzheimer's Disease. 86:1727-1744

Background: Amyloid-β (Aβ) is a principal cleavage product of amyloid-β protein precursor (AβPP) and is widely recognized as a key pathogenic player in Alzheimer’s disease (AD). Yet, there is increasing evidence of a neurotoxic role for the Aβ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5fbb50d8c4f8dc7a82cfd757ccb6d2a8
https://doi.org/10.3233/jad-215108

P3‐156: THE CYSTEINE‐RICH WHEY PROTEIN, IMMUNOCAL®, RESCUES REELIN EXPRESSION IN THE HAPP SWEIND TRANSGENIC MOUSE MODEL OF ALZHEIMER'S DISEASE

Autor: Alexandra A. Sandberg, Holly Fleming, Daniel A. Linseman, Nathan Duval

Publikováno v: Alzheimer's & Dementia. 14

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3974d024f12da9eb6123345d5bcdab4
https://doi.org/10.1016/j.jalz.2018.06.1514

A novel anti-apoptotic role for Cdc42/ACK-1 signaling in neurons.

Autor: Punessen NC; Department of Biological Sciences, University of Denver, Denver, CO, USA., Pena C; Department of Biological Sciences, University of Denver, Denver, CO, USA., Sandberg A; Department of Biological Sciences, University of Denver, Denver, CO, USA., Koza LA; Department of Biological Sciences, University of Denver, Denver, CO, USA., Linseman DA; Department of Biological Sciences, University of Denver, Denver, CO, USA; Knoebel Institute for Healthy Aging, University of Denver, Denver, CO, USA. Electronic address: daniel.linseman@du.edu.

Publikováno v: Molecular and cellular neurosciences [Mol Cell Neurosci] 2023 Sep; Vol. 126, pp. 103865. Date of Electronic Publication: 2023 May 31.