Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Alexandra A Gavidia"'
Autor:
Aviva Levitas, Emad Muhammad, Yuan Zhang, Isaac Perea Gil, Ricardo Serrano, Nashielli Diaz, Maram Arafat, Alexandra A Gavidia, Michael S Kapiloff, Mark Mercola, Yoram Etzion, Ruti Parvari, Ioannis Karakikes
Publikováno v:
PLoS Genetics, Vol 16, Iss 9, p e1009000 (2020)
Dilated cardiomyopathy (DCM) is a common cause of heart failure and sudden cardiac death. It has been estimated that up to half of DCM cases are hereditary. Mutations in more than 50 genes, primarily autosomal dominant, have been reported. Although r
Externí odkaz:
https://doaj.org/article/d5b2baa88b9047f9b0556780536f082f
Autor:
Joseph Adu, Mark Fordjour Owusu, Ebenezer Martin-Yeboah, Lisbeth Alexandra Pino Gavidia, Sebastian Gyamfi
Publikováno v:
Methodological Innovations, Vol 15 (2022)
Mixed methods research has become an important approach to research worldwide. The combination of qualitative and quantitative research methods has made it possible for a deeper and broader understanding of multifaceted phenomena, thereby offering re
Externí odkaz:
https://doaj.org/article/ae4546f8e2b2467d9fb34781cc2f5839
Autor:
Prashila L Amatya, Mark Mercola, Jennifer Arthur Ataam, Michelle Vu, Alexandra A Gavidia, Renee G.C. Maas, Wouter P. te Rijdt, Ting-Hsuan Wu, Maricela Prado, Albert J. H. Suurmeijer, Ioannis Karakikes, Logan Dunkenberger, Joost P.G. Sluijter, Isaac Perea-Gil, Nirmal Vadgama, Aryan Vink, Yuan Zhang, Jiayi Pei, Karim Sallam, Magdalena Harakalova, Dries A.M. Feyen, Folkert W. Asselbergs
Publikováno v:
Circulation, 144(5), 382-392. Lippincott Williams and Wilkins
Circulation, 144(5), 382-392. LIPPINCOTT WILLIAMS & WILKINS
Circulation
Circulation, 144(5), 382-392. LIPPINCOTT WILLIAMS & WILKINS
Circulation
Background: Phospholamban (PLN) is a critical regulator of calcium cycling and contractility in the heart. The loss of arginine at position 14 in PLN (R14del) is associated with dilated cardiomyopathy with a high prevalence of ventricular arrhythmias
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b598da7adccee3845068562c6754cc13
https://research.rug.nl/en/publications/53ce900f-a727-4f43-856f-e44f401904b9
https://research.rug.nl/en/publications/53ce900f-a727-4f43-856f-e44f401904b9
Publikováno v:
Stem Cell Research, Vol 57, Iss, Pp 102610-(2021)
Prime editing uses the Cas9 nickase fused to a reverse transcriptase to copy a DNA sequence into a specific locus from a ‘prime editing’ guide RNA (pegRNA), eliminating the need for double-stranded DNA breaks and donor DNA templates. To facilitat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f57c4db2b4c89584041359f389e9c7c
http://www.sciencedirect.com/science/article/pii/S1873506121004578
http://www.sciencedirect.com/science/article/pii/S1873506121004578
Autor:
Eyal, Metzl-Raz, Nike, Bharucha, Jennifer, Arthur Ataam, Alexandra A, Gavidia, William J, Greenleaf, Ioannis, Karakikes
Publikováno v:
Stem Cell Research. 61:102754
Temporal regulation of CRISPRi activity is critical for genetic screens. Here, we present an inducible CRISPRi platform enabling selection of iPSC-derived cardiomyocytes and reversible gene knockdown. We targeted a doxycycline-inducible dCas9-KRAB-mC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a85fb18c84a54e9c31a6413ab4fa33
https://doi.org/10.1016/j.scr.2022.102754
https://doi.org/10.1016/j.scr.2022.102754
Autor:
Emad Muhammad, Ricardo Serrano, Ruti Parvari, Alexandra A Gavidia, Isaac Perea Gil, Nashielli Diaz, Yoram Etzion, Michael S. Kapiloff, Yuan Zhang, Maram Arafat, Aviva Levitas, Mark Mercola, Ioannis Karakikes
Publikováno v:
PLoS Genetics, Vol 16, Iss 9, p e1009000 (2020)
PLoS Genetics
PLoS Genetics
Dilated cardiomyopathy (DCM) is a common cause of heart failure and sudden cardiac death. It has been estimated that up to half of DCM cases are hereditary. Mutations in more than 50 genes, primarily autosomal dominant, have been reported. Although r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db590fdc5e07696548c6ff0e43a7e5aa
https://doaj.org/article/d5b2baa88b9047f9b0556780536f082f
https://doaj.org/article/d5b2baa88b9047f9b0556780536f082f
Autor:
Isaac Perea-Gil, Timon Seeger, Arne A N Bruyneel, Vittavat Termglinchan, Emma Monte, Esther W Lim, Nirmal Vadgama, Takaaki Furihata, Alexandra A Gavidia, Jennifer Arthur Ataam, Nike Bharucha, Noel Martinez-Amador, Mohamed Ameen, Pooja Nair, Ricardo Serrano, Balpreet Kaur, Dries A M Feyen, Sebastian Diecke, Michael P Snyder, Christian M Metallo, Mark Mercola, Ioannis Karakikes
Publikováno v:
European heart journal. 43(36)
Aims Genetic dilated cardiomyopathy (DCM) is a leading cause of heart failure. Despite significant progress in understanding the genetic aetiologies of DCM, the molecular mechanisms underlying the pathogenesis of familial DCM remain unknown, translat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ddc5091dc82fe213977734820a186ca
https://pubmed.ncbi.nlm.nih.gov/35923092
https://pubmed.ncbi.nlm.nih.gov/35923092
Autor:
Alexandra A Gavidia, Isaac Perea Gil, Jennifer Arthur, Mohamed Ameen, Kevin C. Wang, Ioannis Karakikes, Nike Bharucha, Yuan Zhang
Publikováno v:
Circulation Research. 127
Background: LMNA , a gene encoding A-type lamin proteins (abbreviated as lamin A), is one of the most frequently mutated genes in dilated cardiomyopathy (DCM). The molecular mechanisms underlying cardiomyocyte dysfunction in LMNA -related DCM remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ec87564ba115b78f28f81d9fd04649d
https://doi.org/10.1161/res.127.suppl_1.mp175
https://doi.org/10.1161/res.127.suppl_1.mp175
Autor:
Nirmal Vadgama, Isaac Perea Gil, Angelos Oikonomopoulos, Santiago Roura, Nadjet Bellbachir, Joseph C. Wu, Ioannis Karakikes, Alexandra A Gavidia, Yuan Zhang, Antoni Bayes-Genis, Jennifer Arthur
Publikováno v:
Circulation Research. 127
Background: Hypertrophic cardiomyopathy (HCM) is the most prevalent form of genetic cardiomyopathy associated with ventricular arrhythmia and sudden cardiac death. To date, several pathogenic variants of sarcomeric protein genes have been identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a267637c7f2fecb98d790c0e5e3b1cbb
https://doi.org/10.1161/res.127.suppl_1.274
https://doi.org/10.1161/res.127.suppl_1.274
Publikováno v:
Stem Cell Research, Vol 57, Iss , Pp 102610- (2021)
Prime editing uses the Cas9 nickase fused to a reverse transcriptase to copy a DNA sequence into a specific locus from a ‘prime editing’ guide RNA (pegRNA), eliminating the need for double-stranded DNA breaks and donor DNA templates. To facilitat
Externí odkaz:
https://doaj.org/article/46f4a820a4ed40ed928cbf7c3bc1281a