Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Alexandra Sporn"'
Autor:
Wendy Sharp, Alexandra Sporn, Peter Gochman, Catherine Stayer, Deanna Greenstein, Nitin Gogtay, Julia W. Tossell, Judith L. Rapoport, Marge Lenane
Publikováno v:
Journal of Child and Adolescent Psychopharmacology. 15:510-519
Long-term outcomes in children with atypical psychosis have been poorly studied. Four to 6 weeks of inpatient observation and up to 11 years (mean, 4.0 +/- 1.3 years) of follow- up have afforded us some experience with this probably heterogeneous gro
Autor:
Marge Lenane, Daniel R. Weinberger, Daniel W. Hommer, Franziska Sailer, Robert R. Rawlings, Deanna Greenstein, Nitin Gogtay, Judith L. Rapoport, Rob Nicolson, Alexandra Sporn, Michael F. Egan, Peter Gochman
Publikováno v:
Schizophrenia Research. 73:243-252
Background Childhood-onset schizophrenia (COS), a severe form of the disorder, is of interest for etiologic studies. Smooth pursuit eye-tracking dysfunction (ETD) is a biological marker for schizophrenia. Aims To compare familial eye-tracking abnorma
Autor:
Richard E. Straub, Dede Greenstein, Natalie Baker, D.R. Weinberger, Alexandra Sporn, Judith L. Rapoport, Aaron J. Bobb, Radhakrishna Vakkalanka, Peter Gochman, Michele C. Gornick, Nitin Gogtay, J Duckworth, Marge Lenane, Rishi Balkissoon, Anjené M. Addington
Publikováno v:
Molecular Psychiatry. 10:581-588
Postmortem brain studies have shown deficits in the cortical gamma-aminobutyric acid (GABA) system in schizophrenic individuals. Expression studies have shown a decrease in the major GABA-synthesizing enzyme (glutamic acid decarboxylase (GAD67) mRNA
Autor:
Anna L. Davidson, Judith L. Rapoport, Thomas F. Nugent, Julia W. Tossell, Susan B. Job, Marge Lenane, Peter Gochman, Nitin Gogtay, Alexandra Sporn, Deanna Greenstein
Publikováno v:
Journal of Child and Adolescent Psychopharmacology. 14:448-454
The administration of psychostimulants to children with psychotic symptoms is controversial. This study reports the stimulant drug response of 5 children, aged 8-15 years, with childhood-onset schizophrenia (COS) and comorbid attention deficit hypera
Autor:
Alexandra Sporn, Richard E. Straub, Nitin Gogtay, Anjené M. Addington, Michele C. Gornick, Judith L. Rapoport, Liv S. Clasen, Deanna Greenstein, Marge Lenane, Wendy Sharp, Julia W. Tossell, Peter Gochman, Anna E. Ordóñez
Publikováno v:
Biological Psychiatry. 55:989-994
Background Childhood-onset schizophrenia (COS) is a severe form of the adult-onset disorder with a high rate of premorbid developmental abnormalities. Early symptoms of pervasive developmental disorder (PDD) have been reported in five independent stu
Autor:
Cara L. Alfaro, Marianne Wudarsky, Peter Gochman, Judith L. Rapoport, Marge Lenane, Rob Nicolson, Alexandra Sporn
Publikováno v:
Journal of Child and Adolescent Psychopharmacology. 12:83-91
Patients with a Diagnostic and Statistical Manual of Mental Disorders (third edition, revised) diagnosis of schizophrenia or psychotic disorder not otherwise specified with onset of psychosis before the age of 13 participated in 6- to 8-week open or
Autor:
Jeffrey S. Bedwell, Daniel W. Hommer, Elizabeth Israel, Rob Nicolson, Marge Lenane, Leslie K. Jacobsen, Gunvant K. Thaker, Judith L. Rapoport, Peter Gochman, Sanjiv Kumra, Alexandra Sporn
Publikováno v:
American Journal of Psychiatry. 158:1291-1298
Although childhood-onset schizophrenia is relatively rare, a sizable group of children with severe emotional disturbances have transient psychotic symptoms that fall outside of current syndrome boundaries. The relationship of this group of children t
Autor:
Alexandra Sporn, Judith L. Rapoport
Publikováno v:
Child and Adolescent Psychopharmacology News. 6:1-6
Background : Childhood-onset schizophrenia is a rare but severe form of the disorder that is often treatment-refractory. In this study, the efficacy and adverse effects of clozapine and haloperidol were compared for children and adolescents with earl
Publikováno v:
The journal of ECT. 25(1)
Objectives Previous studies of repetitive transcranial magnetic stimulation suggest a hemispheric imbalance in patients with major depression. These studies report an antidepressant effect by activation of the left prefrontal cortex or inhibition of
Autor:
Alexandra Sporn, D.R. Weinberger, Richard E. Straub, Radhakrishna Vakkalanka, Peter Gochman, Marge Lenane, Rishi Balkissoon, Michele C. Gornick, Anna E. Ordóñez, Judith L. Rapoport, Dede Greenstein, Anjené M. Addington, Nitin Gogtay
Publikováno v:
Journal of autism and developmental disorders. 35(6)
Straub et al. (2002) recently identified the 6p22.3 gene dysbindin (DTNBP1) through positional cloning as a schizophrenia susceptibility gene. We studied a rare cohort of 102 children with onset of psychosis before age 13. Standardized ratings of ear