The Main Therapeutic Applications of Cannabidiol (CBD) and Its Potential Effects on Aging with Respect to Alzheimer’s Disease

Autor: Václav Trojan, Leoš Landa, Alexandra Šulcová, Jiří Slíva, Radovan Hřib

Publikováno v: Biomolecules, Vol 13, Iss 10, p 1446 (2023)

The use of cannabinoids (substances contained specifically in hemp plants) for therapeutic purposes has received increased attention in recent years. Presently, attention is paid to two main cannabinoids: delta-9-tetrahydrocannabinol (THC) and cannab

Externí odkaz: https://doaj.org/article/e0f702bd492341ceb950c00c20caa5ba

Altered dopamine D3 receptor gene expression in MAM model of schizophrenia is reversed by peripubertal cannabidiol treatment

Autor: Claudio Bucolo, Alexandra Šulcová, Martina Di Bartolomeo, Julia Fedotova, Tibor Štark, Lucie Krátká, Fabiana Piscitelli, Carsten T. Wotjak, Raphael Mechoulam, Vincenzo Micale, Claudio D'Addario, Chiara Bianca Maria Platania, Jana Ruda-Kucerova, Zenon Starčuk, Fabio Arturo Iannotti, Salvatore Salomone, Eva Drazanova, Vladimir Pekarik, Filippo Drago, Zuzana Babinská, Vincenzo Di Marzo, Giovanni Giurdanella, Roberta Di Marco

Publikováno v: Biochemical pharmacology. 177

Gestational methylazoxymethanol acetate (MAM) treatment produces offspring with adult phenotype relevant to schizophrenia, including positive- and negative-like symptoms, cognitive deficits, dopaminergic dysfunction, structural and functional abnorma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7ff8d4d7754492edfd650196c20c6d
https://pubmed.ncbi.nlm.nih.gov/32360362

A preliminary study of endocannabinoid system regulation in psychosis: Distinct alterations of CNR1 promoter DNA methylation in patients with schizophrenia

Autor: Tibor Štark, Filippo Drago, Zuzana Babinská, A. Carlo Altamura, Mauro Maccarrone, Bernardo Dell'Osso, Claudio D'Addario, Vincenzo Micale, Laura Cremaschi, Alexandra Šulcová, Martina Di Bartolomeo, M.C. Palazzo, Mariangela Pucci

Publikováno v: Schizophrenia Research. 188:132-140

Compelling evidence supports the involvement of the endocannabinoid system (ECS) in psychosis vulnerability. We here evaluated the transcriptional regulation of ECS components in human peripheral blood mononuclear cells (PBMCs) obtained from subjects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d0e62265dfc82f6ab68002bb723eec
https://doi.org/10.1016/j.schres.2017.01.022

Peripubertal cannabidiol treatment rescued behavioral and neurochemical abnormalities in the MAM model of schizophrenia

Autor: Monica Bari, Salvatore Salomone, Tibor Štark, Alexandra Šulcová, Martina Di Bartolomeo, Jana Ruda-Kucerova, Mauro Maccarrone, Vladimir Pekarik, Vincenzo Micale, Carsten T. Wotjak, Claudio D'Addario, Giovanni Giurdanella, Vincenzo Di Marzo, Fabiana Piscitelli, Fabio Arturo Iannotti, Zuzana Babinská, Eva Drazanova, Raphael Mechoulam, Zenon Starčuk, Filippo Drago, Roberta Di Marco

Publikováno v: Neuropharmacology 146 (2019): 212–221. doi:10.1016/j.neuropharm.2018.11.035
info:cnr-pdr/source/autori:Stark T.; Ruda-Kucerova J.; Iannotti F.A.; D'Addario C.; Di Marco R.; Pekarik V.; Drazanova E.; Piscitelli F.; Bari M.; Babinska Z.; Giurdanella G.; Di Bartolomeo M.; Salomone S.; Sulcova A.; Maccarrone M.; Wotjak C.T.; Starcuk Z.; Drago F.; Mechoulam R.; Di Marzo V.; Micale V./titolo:Peripubertal cannabidiol treatment rescues behavioral and neurochemical abnormalities in the MAM model of schizophrenia/doi:10.1016%2Fj.neuropharm.2018.11.035/rivista:Neuropharmacology/anno:2019/pagina_da:212/pagina_a:221/intervallo_pagine:212–221/volume:146

In agreement with the neurodevelopmental hypothesis of schizophrenia, prenatal exposure of rats to the antimitotic agent methylazoxymethanol acetate (MAM) at gestational day 17 produced long-lasting behavioral alterations such as social withdrawal an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30fd4c02d3ffa5369452fe6e12de7de6
http://hdl.handle.net/11575/102216

The use of cannabinoids in animals and therapeutic implications for veterinary medicine: a review

Autor: Petr Gbelec, Leoš Landa, Alexandra Šulcová

Publikováno v: Veterinární medicína. 61:111-122

This review sets out to comprehensively summarise well known facts concerning properties of cannabinoids, their mechanisms of action, role of cannabinoid receptors and their classification. It outlines the main pharmacological effects of cannabinoids

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7245329fbcd59815744075a7ac7ede0b
https://doi.org/10.17221/8762-vetmed