Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Alexandra, Tsitsiklis"'
Autor:
Victoria T. Chu, Alexandra Tsitsiklis, Eran Mick, Lilliam Ambroggio, Katrina L. Kalantar, Abigail Glascock, Christina M. Osborne, Brandie D. Wagner, Michael A. Matthay, Joseph L. DeRisi, Carolyn S. Calfee, Peter M. Mourani, Charles R. Langelier
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Antimicrobial resistant lower respiratory tract infections are an increasing public health threat and an important cause of global mortality. The lung microbiome can influence susceptibility of respiratory tract infections and represents an
Externí odkaz:
https://doaj.org/article/a6e6c725bdd94596848389ca69371515
Autor:
Jason A. Hackney, Haridha Shivram, Jason Vander Heiden, Chris Overall, Luz Orozco, Xia Gao, Eugene Kim, Nathan West, Aditi Qamra, Diana Chang, Arindam Chakrabarti, David F. Choy, Alexis J. Combes, Tristan Courau, Gabriela K. Fragiadakis, Arjun Arkal Rao, Arja Ray, Jessica Tsui, Kenneth Hu, Nicholas F. Kuhn, Matthew F. Krummel, David J. Erle, Kirsten Kangelaris, Aartik Sarma, Zoe Lyon, Carolyn S. Calfee, Prescott G. Woodruff, Rajani Ghale, Eran Mick, Ashley Byrne, Beth Shoshana Zha, Charles Langelier, Carolyn M. Hendrickson, Monique G.P. van der Wijst, George C. Hartoularos, Tianna Grant, Raymund Bueno, David S. Lee, John R. Greenland, Yang Sun, Richard Perez, Anton Ogorodnikov, Alyssa Ward, Chun Jimmie Ye, Thiru Ramalingam, Jacqueline M. McBride, Fang Cai, Anastasia Teterina, Min Bao, Larry Tsai, Ivan O. Rosas, Aviv Regev, Sharookh B. Kapadia, Rebecca N. Bauer, Carrie M. Rosenberger, Yumiko Abe-Jones, Michael Adkisson, K. Mark Ansel, Saurabh Asthana, Alexander Beagle, Sharvari Bhide, Cathy Cai, Saharai Caldera, Maria Calvo, Sidney A. Carrillo, Suzanna Chak, Stephanie Christenson, Zachary Collins, Spyros Darmanis, Angela Detweiler, Catherine DeVoe, Walter Eckalbar, Jeremy Giberson, Ana Gonzalez, Gracie Gordon, Paula Hayakawa Serpa, Alejandra Jauregui, Chayse Jones, Serena Ke, Divya Kushnoor, Tasha Lea, Deanna Lee, Aleksandra Leligdowicz, Yale Liu, Salman Mahboob, Lenka Maliskova, Michael Matthay, Elizabeth McCarthy, Priscila Muñoz-Sandoval, Norma Neff, Viet Nguyen, Nishita Nigam, Randy Parada, Maira Phelps, Logan Pierce, Priya Prasad, Sadeed Rashid, Gabriella Reeder, Nicklaus Rodriguez, Bushra Samad, Andrew Schroeder, Cole Shaw, Alan Shen, Austin Sigman, Pratik Sinha, Matthew Spitzer, Sara Sunshine, Kevin Tang, Luz Torres Altamirano, Alexandra Tsitsiklis, Erden Tumurbaatar, Vaibhav Upadhyay, Alexander Whatley, Andrew Willmore, Michael Wilson, Juliane Winkler, Kristine Wong, Kimberly Yee, Michelle Yu, Mingyue Zhou, Wandi S. Zhu
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107813- (2023)
Summary: Altered myeloid inflammation and lymphopenia are hallmarks of severe infections. We identified the upregulated EN-RAGE gene program in airway and blood myeloid cells from patients with acute lung injury from SARS-CoV-2 or other causes across
Externí odkaz:
https://doaj.org/article/9fcf76e7c2d9439cbd17b0a0b7fa8d89
Autor:
Eran Mick, Alexandra Tsitsiklis, Natasha Spottiswoode, Saharai Caldera, Paula Hayakawa Serpa, Angela M. Detweiler, Norma Neff, Angela Oliveira Pisco, Lucy M. Li, Hanna Retallack, Kalani Ratnasiri, Kayla M. Williamson, Victoria Soesanto, Eric A. F. Simões, Christiana Smith, Lisa Abuogi, Amy Kistler, Brandie D. Wagner, Joseph L. DeRisi, Lilliam Ambroggio, Peter M. Mourani, Charles R. Langelier
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The difference between children and adults in response to SARS-CoV-2 infection is not clearly established. Here the authors use gene expression analysis of nasopharyngeal samples from children and adults and show a higher level of immune response in
Externí odkaz:
https://doaj.org/article/c9e006ab7ba94c9dbbc5609925764a1e
Autor:
Eran Mick, Alexandra Tsitsiklis, Jack Kamm, Katrina L. Kalantar, Saharai Caldera, Amy Lyden, Michelle Tan, Angela M. Detweiler, Norma Neff, Christina M. Osborne, Kayla M. Williamson, Victoria Soesanto, Matthew Leroue, Aline B. Maddux, Eric A.F. Simões, Todd C. Carpenter, Brandie D. Wagner, Joseph L. DeRisi, Lilliam Ambroggio, Peter M. Mourani, Charles R. Langelier
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 7 (2023)
BACKGROUND Lower respiratory tract infection (LRTI) is a leading cause of death in children worldwide. LRTI diagnosis is challenging because noninfectious respiratory illnesses appear clinically similar and because existing microbiologic tests are of
Externí odkaz:
https://doaj.org/article/3d40cc581c784c10b26f47427078cd03
Autor:
Jack Albright, Eran Mick, Estella Sanchez-Guerrero, Jack Kamm, Anthea Mitchell, Angela M. Detweiler, Norma Neff, Alexandra Tsitsiklis, Paula Hayakawa Serpa, Kalani Ratnasiri, Diane Havlir, Amy Kistler, Joseph L. DeRisi, Angela Oliveira Pisco, Charles R. Langelier
Publikováno v:
mSystems, Vol 8, Iss 1 (2023)
ABSTRACT The continued emergence of SARS-CoV-2 variants is one of several factors that may cause false-negative viral PCR test results. Such tests are also susceptible to false-positive results due to trace contamination from high viral titer samples
Externí odkaz:
https://doaj.org/article/ecdfa09b3ddd409f8079623dee8daf85
Autor:
Celine Perier, Emmanuel Nasinghe, Isabelle Charles, Leoson Junior Ssetaba, Vida Ahyong, Derek Bangs, P. Robert Beatty, Nadine Czudnochowski, Amy Diallo, Eli Dugan, Jacqueline M. Fabius, Hildy Fong Baker, Jackson Gardner, Stephen Isaacs, Birungi Joanah, Katrina Kalantar, David Kateete, Matt Knight, Maria Krasilnikov, Nevan J. Krogan, Chaz Langelier, Eric Lee, Lucy M. Li, Daniel Licht, Katie Lien, Zilose Lyons, Gerald Mboowa, Ivan Mwebaza, Savannah Mwesigwa, Geraldine Nalwadda, Robert Nichols, Maria Elena Penaranda, Sarah Petnic, Maira Phelps, Stephen J. Popper, Michael Rape, Arthur Reingold, Richard Robbins, Oren S. Rosenberg, David F. Savage, Samuel Schildhauer, Matthew L. Settles, Ivan Sserwadda, Sarah Stanley, Cristina M. Tato, Alexandra Tsitsiklis, Erik Van Dis, Manu Vanaerschot, Joanna Vinden, Jeffery S. Cox, Moses L. Joloba, Julia Schaletzky
Publikováno v:
Global Health Action, Vol 15, Iss 1 (2022)
Science education and research have the potential to drive profound change in low- and middle-income countries (LMICs) through encouraging innovation, attracting industry, and creating job opportunities. However, in LMICs, research capacity is often
Externí odkaz:
https://doaj.org/article/a7c38009f6404c1d8f6807180da59309
Autor:
Aartik Sarma, Stephanie A. Christenson, Ashley Byrne, Eran Mick, Angela Oliveira Pisco, Catherine DeVoe, Thomas Deiss, Rajani Ghale, Beth Shoshana Zha, Alexandra Tsitsiklis, Alejandra Jauregui, Farzad Moazed, Angela M. Detweiler, Natasha Spottiswoode, Pratik Sinha, Norma Neff, Michelle Tan, Paula Hayakawa Serpa, Andrew Willmore, K. Mark Ansel, Jennifer G. Wilson, Aleksandra Leligdowicz, Emily R. Siegel, Marina Sirota, Joseph L. DeRisi, Michael A. Matthay, COMET Consortium, Carolyn M. Hendrickson, Kirsten N. Kangelaris, Matthew F. Krummel, Prescott G. Woodruff, David J. Erle, Carolyn S. Calfee, Charles R. Langelier
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Here, the authors perform transcriptional profiling on tracheal aspirates of adults requiring mechanical ventilation for SARS-CoV2-induced acute respiratory distress syndrome (ARDS) and identify a dysregulated host response predicted to predicted to
Externí odkaz:
https://doaj.org/article/5e15572a162f473290932a34e9eb1ffa
Autor:
Yang Wang, Alexandra Tsitsiklis, Stephanie Devoe, Wei Gao, H. Hamlet Chu, Yan Zhang, Wei Li, Wing Ki Wong, Charlotte M. Deane, David Neau, Jill E. Slansky, Paul G. Thomas, Ellen A. Robey, Shaodong Dai
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Certain CD8 T cell responses are particularly effective at controlling infection, as exemplified by elite control of HIV in individuals harboring HLA-B57. To understand the structural features that contribute to CD8 T cell elite control, we focused o
Externí odkaz:
https://doaj.org/article/7ffa5a501e02421090f8abaab1877c09
Autor:
Alexandra Tsitsiklis, PhD, Christina M Osborne, MD, Jack Kamm, PhD, Kayla Williamson, MS, Katrina Kalantar, PhD, Gytis Dudas, PhD, Saharai Caldera, BA, Amy Lyden, BA, Michelle Tan, BS, Norma Neff, PhD, Victoria Soesanto, BS, J Kirk Harris, PhD, Lilliam Ambroggio, PhD, Aline B Maddux, MD, Todd C Carpenter, MD, Ron W Reeder, PhD, Chris Locandro, MS, Eric A F Simões, ProfMD, Matthew K Leroue, MD, Mark W Hall, ProfMD, Athena F Zuppa, ProfMD, Joseph Carcillo, ProfMD, Kathleen L Meert, ProfMD, Anil Sapru, ProfMD, Murray M Pollack, ProfMD, Patrick S McQuillen, ProfMD, Daniel A Notterman, ProfMD, J Michael Dean, ProfMD, Matt S Zinter, MD, Brandie D Wagner, PhD, Joseph L DeRisi, ProfPhD, Peter M Mourani, ProfMD, Charles R Langelier, MDPhD
Publikováno v:
The Lancet Microbe, Vol 3, Iss 4, Pp e284-e293 (2022)
Summary: Background: Lower respiratory tract infections (LRTI) are a leading cause of critical illness and mortality in mechanically ventilated children; however, the pathogenic microbes frequently remain unknown. We combined traditional diagnostics
Externí odkaz:
https://doaj.org/article/bf9afb105f554ba7841ff015408ec805
Autor:
Alexander J Ehrenberg, Erica A Moehle, Cara E Brook, Andrew H Doudna Cate, Lea B Witkowsky, Rohan Sachdeva, Ariana Hirsh, Kerrie Barry, Jennifer R Hamilton, Enrique Lin-Shiao, Shana McDevitt, Luis Valentin-Alvarado, Kaitlyn N Letourneau, Lauren Hunter, Amanda Keller, Kathleen Pestal, Phillip A Frankino, Andrew Murley, Divya Nandakumar, Elizabeth C Stahl, Connor A Tsuchida, Holly K Gildea, Andrew G Murdock, Megan L Hochstrasser, Elizabeth O'Brien, Alison Ciling, Alexandra Tsitsiklis, Kurtresha Worden, Claire Dugast-Darzacq, Stephanie G Hays, Colin C Barber, Riley McGarrigle, Emily K Lam, David C Ensminger, Lucie Bardet, Carolyn Sherry, Anna Harte, Guy Nicolette, Petros Giannikopoulos, Dirk Hockemeyer, Maya Petersen, Fyodor D Urnov, Bradley R Ringeisen, Mike Boots, Jennifer A Doudna, IGI SARS-CoV-2 Testing Consortium
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0251296 (2021)
Regular surveillance testing of asymptomatic individuals for SARS-CoV-2 has been center to SARS-CoV-2 outbreak prevention on college and university campuses. Here we describe the voluntary saliva testing program instituted at the University of Califo
Externí odkaz:
https://doaj.org/article/336066b4b23e4529865ab446851e9116