Zobrazeno 1 - 10
of 203
pro vyhledávání: '"Alexandra, Trkola"'
Autor:
Magdalena Schwarzmüller, Cristina Lozano, Merle Schanz, Irene A. Abela, Silvan Grosse-Holz, Selina Epp, Martina Curcio, Jule Greshake, Peter Rusert, Michael Huber, Roger D. Kouyos, Huldrych F. Günthard, Alexandra Trkola
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101702- (2024)
Summary: The development of broadly neutralizing antibody (bnAb)-based therapeutic HIV-1 vaccines and cure concepts depends on monitoring bnAb plasma activity in people with HIV (PWH) on suppressive antiretroviral therapy (ART). To enable this, analy
Externí odkaz:
https://doaj.org/article/a726c3b8bb5347b0a26db15a5cdb413e
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103056- (2024)
Summary: Therapeutic use of HIV-1 broadly neutralizing antibodies (bnAbs), passively administered or induced by therapeutic vaccines, is a focus of advanced treatment strategies under development. To enable monitoring of bnAb activity during concurre
Externí odkaz:
https://doaj.org/article/20c7187eb22842cba00cb82bd65d5b15
Autor:
Fanny Wegner, Blanca Cabrera-Gil, Araud Tanguy, Christiane Beckmann, Niko Beerenwinkel, Claire Bertelli, Matteo Carrara, Lorenzo Cerutti, Chaoran Chen, Samuel Cordey, Alexis Dumoulin, Louis du Plessis, Marc Friedli, Yannick Gerth, Gilbert Greub, Adrian Härri, Hans Hirsch, Cedric Howald, Michael Huber, Alexander Imhof, Laurent Kaiser, Verena Kufner, Stephen L. Leib, Karoline Leuzinger, Etleva Lleshi, Gladys Martinetti, Mirjam Mäusezahl, Milo Moraz, Richard Neher, Oliver Nolte, Alban Ramette, Maurice Redondo, Lorenz Risch, Lionel Rohner, Tim Roloff, Pascal Schläepfer, Katrin Schneider, Franziska Singer, Valeria Spina, Tanja Stadler, Erik Studer, Ivan Topolsky, Alexandra Trkola, Daniel Walther, Nadia Wohlwend, Cinzia Zehnder, Aitana Neves, Adrian Egli
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 5 (2024)
ABSTRACTDuring the SARS-CoV-2 pandemic, many countries directed substantial resources toward genomic surveillance to detect and track viral variants. There is a debate over how much sequencing effort is necessary in national surveillance programs for
Externí odkaz:
https://doaj.org/article/c4ccaa18016f452ba4419207aed44b4b
Autor:
Verena Kufner, Andrea C. Frey, Sara H. Burkhard, Stefan Schmutz, Gabriela Ziltener, Maryam Zaheri, Caroline V. Wiedmer, Andreas Plate, Alexandra Trkola, Michael Huber, Nicolas J. Mueller
Publikováno v:
Swiss Medical Weekly, Vol 154, Iss 4 (2024)
AIMS OF THE STUDY: Upper respiratory tract infections are among the most common reasons for primary care consultations. They are diagnosed predominantly based on clinical assessment. Here, we investigated the benefit of viral metagenomic next-generat
Externí odkaz:
https://doaj.org/article/7e495464ca974744b327ddaf778b99f2
Autor:
Liridona Maliqi, Nikolas Friedrich, Matthias Glögl, Stefan Schmutz, Daniel Schmidt, Peter Rusert, Merle Schanz, Maryam Zaheri, Chloé Pasin, Cyrille Niklaus, Caio Foulkes, Thomas Reinberg, Birgit Dreier, Irene Abela, David Peterhoff, Alexandra Hauser, Roger D. Kouyos, Huldrych F. Günthard, Marit J. van Gils, Rogier W. Sanders, Ralf Wagner, Andreas Plückthun, Alexandra Trkola
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-14 (2023)
Abstract Understanding the balance between epitope shielding and accessibility on HIV-1 envelope (Env) trimers is essential to guide immunogen selection for broadly neutralizing antibody (bnAb) based vaccines. To investigate the antigenic space of En
Externí odkaz:
https://doaj.org/article/3c1b7ec8277b4efcb7d60e82c1710437
Autor:
Irene A. Abela, Magdalena Schwarzmüller, Agne Ulyte, Thomas Radtke, Sarah R. Haile, Priska Ammann, Alessia Raineri, Sonja Rueegg, Selina Epp, Christoph Berger, Jürg Böni, Amapola Manrique, Annette Audigé, Michael Huber, Peter W. Schreiber, Thomas Scheier, Jan Fehr, Jacqueline Weber, Peter Rusert, Huldrych F. Günthard, Roger D. Kouyos, Milo A. Puhan, Susi Kriemler, Alexandra Trkola, Chloé Pasin
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT Numerous clinical parameters link to severe coronavirus disease 2019, but factors that prevent symptomatic disease remain unknown. We investigated the impact of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) and endemic hu
Externí odkaz:
https://doaj.org/article/872636c2b790494c92aab9ac0e622d10
Autor:
Lisa Perrig, Irene A. Abela, Nicolas Banholzer, Annette Audigé, Selina Epp, Catrina Mugglin, Kathrin Zürcher, Matthias Egger, Alexandra Trkola, Lukas Fenner
Publikováno v:
Swiss Medical Weekly, Vol 153, Iss 12 (2023)
BACKGROUND: Given their high-risk resident population, nursing homes were critical institutions in the COVID-19 pandemic, calling for continued monitoring and vaccine administration to healthcare workers and residents. Here, we studied long-term seve
Externí odkaz:
https://doaj.org/article/43c4abed8bfa45fdaaad1391800d5574
Autor:
Irene A. Abela, Chloé Pasin, Magdalena Schwarzmüller, Selina Epp, Michèle E. Sickmann, Merle M. Schanz, Peter Rusert, Jacqueline Weber, Stefan Schmutz, Annette Audigé, Liridona Maliqi, Annika Hunziker, Maria C. Hesselman, Cyrille R. Niklaus, Jochen Gottschalk, Eméry Schindler, Alexander Wepf, Urs Karrer, Aline Wolfensberger, Silvana K. Rampini, Patrick M. Meyer Sauteur, Christoph Berger, Michael Huber, Jürg Böni, Dominique L. Braun, Maddalena Marconato, Markus G. Manz, Beat M. Frey, Huldrych F. Günthard, Roger D. Kouyos, Alexandra Trkola
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
How the immune responses induced by SARS-CoV-2 and human coronavirus (hCoV) crosstalk is still unclear. Here the authors profile the humoral responses of prepandemic and SARS-CoV-2-infected donors to find that higher hCoV antibody titers are associat
Externí odkaz:
https://doaj.org/article/9ae1432b592c419493eac058f90406ee
Autor:
Nikolas Friedrich, Emanuel Stiegeler, Matthias Glögl, Thomas Lemmin, Simon Hansen, Claus Kadelka, Yufan Wu, Patrick Ernst, Liridona Maliqi, Caio Foulkes, Mylène Morin, Mustafa Eroglu, Thomas Liechti, Branislav Ivan, Thomas Reinberg, Jonas V. Schaefer, Umut Karakus, Stephan Ursprung, Axel Mann, Peter Rusert, Roger D. Kouyos, John A. Robinson, Huldrych F. Günthard, Andreas Plückthun, Alexandra Trkola
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The V3-crown of the HIV-1 envelope protein largely elicits non-neutralizing antibodies. Here, the authors show that the V3-crown can be targeted by broadly neutralizing designed ankyrin repeat proteins recognizing two conformations one of which resem
Externí odkaz:
https://doaj.org/article/ecac0450d3ce4cd7a9cab854f96059f2
Autor:
Benjamin Speich, Frédérique Chammartin, Daniel Smith, Marcel P. Stoeckle, Patrizia Amico, Anna L. Eichenberger, Barbara Hasse, Macé M. Schuurmans, Thomas Müller, Michael Tamm, Michael Dickenmann, Irene A. Abela, Alexandra Trkola, Hans H. Hirsch, Oriol Manuel, Matthias Cavassini, Lars G. Hemkens, Matthias Briel, Nicolas J. Mueller, Andri Rauch, Huldrych F. Günthard, Michael T. Koller, Heiner C. Bucher, Katharina Kusejko, in collaboration with the study groups from the Swiss HIV Cohort Study and the Swiss Transplant Cohort Study
Publikováno v:
Trials, Vol 22, Iss 1, Pp 1-16 (2021)
Abstract Background Late 2019, a new highly contagious coronavirus SARS-CoV-2 has emerged in Wuhan, China, causing within 2 months a pandemic with the highest disease burden in elderly and people with pre-existing medical conditions. The pandemic has
Externí odkaz:
https://doaj.org/article/2128b74ef7444eeeafbfd6921999843a