Analysis of RBP expression and binding sites identifies PTBP1 as a regulator of CD19 expression in B-ALL

Autor: Nicole Ziegler, Mariela Cortés-López, Francesca Alt, Maximilian Sprang, Arsenij Ustjanzew, Nadine Lehmann, Khalifa El Malki, Arthur Wingerter, Alexandra Russo, Olaf Beck, Sebastian Attig, Lea Roth, Julian König, Claudia Paret, Jörg Faber

Publikováno v: OncoImmunology, Vol 12, Iss 1 (2023)

ABSTRACTDespite massive improvements in the treatment of B-ALL through CART-19 immunotherapy, a large number of patients suffer a relapse due to loss of the targeted epitope. Mutations in the CD19 locus and aberrant splicing events are known to accou

Externí odkaz: https://doaj.org/article/2b706a5b32624427bf13e1bdcb10eeb5

Benefits of Exercise Training for Children and Adolescents Undergoing Cancer Treatment: Results From the Randomized Controlled MUCKI Trial

Autor: Sandra Stössel, Marie A. Neu, Arthur Wingerter, Wilhelm Bloch, Philipp Zimmer, Claudia Paret, Khalifa El Malki, Freerk T. Baumann, Alexandra Russo, Nicole Henninger, Nadine Lehmann, Henrike Otto, Jörg Faber

Publikováno v: Frontiers in Pediatrics, Vol 8 (2020)

Objective: In cancer patients, the impairment in muscle function is a frequently observed phenomenon. However, comprehensive evaluation of the effect of exercise training on muscle function in childhood cancer patients (CCPs) is sparse and therefore

Externí odkaz: https://doaj.org/article/4c37caae9ca7403baef8bdd3b80d3a74

Glucosylceramide Synthase Inhibitors Induce Ceramide Accumulation and Sensitize H3K27 Mutant Diffuse Midline Glioma to Irradiation

Autor: Faber, Khalifa El Malki, Pia Wehling, Francesca Alt, Roger Sandhoff, Sebastian Zahnreich, Arsenij Ustjanzew, Carolin Wilzius, Marc A. Brockmann, Arthur Wingerter, Alexandra Russo, Olaf Beck, Clemens Sommer, Malte Ottenhausen, Katrin B. M. Frauenknecht, Claudia Paret, Jörg

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 12; Pages: 9905

H3K27M mutant (mut) diffuse midline glioma (DMG) is a lethal cancer with no effective cure. The glycosphingolipids (GSL) metabolism is altered in these tumors and could be exploited to develop new therapies. We tested the effect of the glucosylcerami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::d06971d15320f33efa010e3dfe7f51d3

Wnd/DLK Is a Critical Target of FMRP Responsible for Neurodevelopmental and Behavior Defects in the Drosophila Model of Fragile X Syndrome

Autor: Alexandra Russo, Aaron DiAntonio

Publikováno v: Cell Reports, Vol 28, Iss 10, Pp 2581-2593.e5 (2019)

Summary: Fragile X syndrome (FXS) is the leading heritable cause of intellectual disability and commonly co-occurs with autism spectrum disorder. Silencing of the Fmr1 gene leads to the absence of the protein product, fragile X mental retardation pro

Externí odkaz: https://doaj.org/article/73edf97061b5426aad3c3ade100ef1a2

Current recommendations for cancer surveillance in Gorlin syndrome: a report from the SIOPE host genome working group (SIOPE HGWG)

Autor: O Michaeli, N Waespe, Laurence Brugières, Christian P. Kratz, Miriam J. Smith, Alexandra Russo, Steffen Hirsch, D G Evans, Saskia M. J. Hopman, B Doergeloh, H Salvador, V. Ridola, M. Jorgensen, T Milde, Léa Guerrini-Rousseau, B Claret, M Kuhlen

Publikováno v: Familial Cancer
FAM CANCER
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
Guerrini-Rousseau, L; Smith, M J; Kratz, C P; Doergeloh, B; Hirsch, S; Hopman, S M J; Jorgensen, M; Kuhlen, M; Michaeli, O; Milde, T; Ridola, V; Russo, A; Salvador, H; Waespe, N; Claret, B; Brugieres, L; Evans, D G (2021). Current recommendations for cancer surveillance in Gorlin syndrome: a report from the SIOPE host genome working group (SIOPE HGWG). Familial Cancer, 20(4), pp. 317-325. Springer 10.1007/s10689-021-00247-z

Gorlin syndrome (MIM 109,400), a cancer predisposition syndrome related to a constitutional pathogenic variation (PV) of a gene in the Sonic Hedgehog pathway (PTCH1 or SUFU), is associated with a broad spectrum of benign and malignant tumors. Basal c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca2099ceaeeb84d4831a8b94a634268
http://europepmc.org/articles/PMC8484213