Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Alexandra, Naß"'
Autor:
Rosaria Ottanà, Paolo Paoli, Mario Cappiello, Trung Ngoc Nguyen, Ilenia Adornato, Antonella Del Corso, Massimo Genovese, Ilaria Nesi, Roberta Moschini, Alexandra Naß, Gerhard Wolber, Rosanna Maccari
Publikováno v:
Molecules, Vol 26, Iss 2, p 330 (2021)
Diabetes mellitus (DM) is a complex disease which currently affects more than 460 million people and is one of the leading cause of death worldwide. Its development implies numerous metabolic dysfunctions and the onset of hyperglycaemia-induced chron
Externí odkaz:
https://doaj.org/article/5dbb82913dc34a5d862083d04bc41b3c
Autor:
Alexandra Naß, Paolo De Paoli, Mario Cappiello, Rosanna Maccari, Francesco Balestri, Gerhard Wolber, Antonella Del Corso, Giulia Lori, Ilenia Adornato, Rosaria Ottanà
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3712-3720
Designed multiple ligands (DMLs), developed to modulate simultaneously a number of selected targets involved in etiopathogenetic mechanisms of a multifactorial disease, such as diabetes mellitus (DM), are considered a promising alternative to combina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6073126821f647fa6752075bff55109a
https://doi.org/10.1016/j.bmcl.2018.10.024
https://doi.org/10.1016/j.bmcl.2018.10.024
Autor:
Xavier de la Torre, Jan Felix Joseph, Lei Chen, Francesco Botrè, Maria Kristina Parr, Alexandra Naß, Matthias Bureik, Jiaxin Liu, Anna Stoll, Gerhard Wolber
Publikováno v:
Journal of Inorganic Biochemistry. 183:165-171
Anabolic androgenic steroids (AAS) are misused very frequently in sport competitions as performance enhancing agents. One of the doping compounds that has been detected with increased frequency in the last few years is dehydrochloromethyltestosterone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50080ef3d08bc4088cad84c0a048c37d
https://doi.org/10.1016/j.jinorgbio.2018.02.020
https://doi.org/10.1016/j.jinorgbio.2018.02.020
Autor:
Gerhard Wolber, Adriana Carol Eleonora Graziano, Ilenia Adornato, Venera Cardile, Rosaria Ottanà, Rosanna Maccari, Archimede Rotondo, Paolo De Paoli, Alexandra Naß, Giulia Lori
Publikováno v:
European Journal of Medicinal Chemistry. 127:840-858
New 4-{[5-arylidene-2-(4-fluorophenylimino)-4-oxothiazolidin-3-yl]methyl}benzoic acids (5) and 2-thioxo-4-thiazolidinone analogues (6) were synthesised as a part of a continuing search for new inhibitors of protein tyrosine phosphatase 1B (PTP1B), an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b2d387709e583003f800ea08f959cae
https://doi.org/10.1016/j.ejmech.2016.10.063
https://doi.org/10.1016/j.ejmech.2016.10.063
Autor:
Ilenia Adornato, Rosanna Maccari, Paolo De Paoli, Giulia Lori, Alexandra Naß, Gerhard Wolber, Santo Previti, Rosaria Ottanà
Protein tyrosine phosphatase 1B (PTP1B) acts as a negative regulator of insulin and leptin signalling and is crucially involved in the development of type 2 diabetes mellitus, obesity, cancer and neurodegenerative diseases. Pursuing our efforts to id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6da24b8595996831c82c38e4f536a33b
http://hdl.handle.net/2158/1171692
http://hdl.handle.net/2158/1171692
Autor:
Roberta Moschini, Ilaria Nesi, Trung Ngoc Nguyen, Antonella Del Corso, Rosanna Maccari, Massimo Genovese, Paolo De Paoli, Ilenia Adornato, Gerhard Wolber, Rosaria Ottanà, Mario Cappiello, Alexandra Naß
Publikováno v:
Molecules
Volume 26
Issue 2
Molecules, Vol 26, Iss 330, p 330 (2021)
Volume 26
Issue 2
Molecules, Vol 26, Iss 330, p 330 (2021)
Diabetes mellitus (DM) is a complex disease which currently affects more than 460 million people and is one of the leading cause of death worldwide. Its development implies numerous metabolic dysfunctions and the onset of hyperglycaemia-induced chron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc68d1010cf1de2f7cbda56990a5249
https://doi.org/10.3390/molecules26020330
https://doi.org/10.3390/molecules26020330
Autor:
Federica Mannino, Giuseppe Bruno, Rosaria Ottanà, Silvana Grasso, Santo Previti, Francesco Nicolò, Alexandra Naß, Gerhard Wolber, Ilenia Adornato, Rosanna Maccari, Maria Zappalà, Alessandra Bitto, Roberta Ettari, Federica Aliquò
This paper describes the design, synthesis, and biological evaluation of 2-thioxoimidazolidin-4-one derivatives as inhibitors of proteasome and immunoproteasome, potential targets for the treatment of hematological malignancies. In particular, we foc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a500e1d8c94be2e46c34801803054e7
http://hdl.handle.net/11570/3119303
http://hdl.handle.net/11570/3119303
Autor:
David Schaller, Alexandra Naß, Holger Stark, Gina Alpert, Robert Schulz, Gerhard Wolber, Stefanie Hagenow, Marcel Bermudez
In this study, we report a ligand-centric data mining approach that guided the identification of suitable target profiles for treating obesity. The newly developed method is based on identifying target pairs for synergistic positive effects and also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f08e80c5c22a61c437f73604fe9db47f
https://europepmc.org/articles/PMC5467185/
https://europepmc.org/articles/PMC5467185/
Publikováno v:
Molecular Informatics. 38:1800141
For drug design projects it is essential to rationally induce and explain selectivity. In this context shape complementarity as well as protein and ligand flexibility represent important factors. Currently available tools for the analysis of protein-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2acd9da835b59a39572057c5dc03e9b3
https://doi.org/10.1002/minf.201800141
https://doi.org/10.1002/minf.201800141