Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Alexandra, Litvinchuk"'
Autor:
David M. Holtzman, Yang Shi, Melissa Manis, Tracy Cole, Tien Phat V. Huynh, Patrick Sullivan, Jason D. Ulrich, Bradley T. Hyman, Caroline M. Francis, Mary Beth Finn, Alexandra Litvinchuk, Rosemary J. Jackson, Ainsley C. Tran
Publikováno v:
Annals of Neurology. 89:952-966
OBJECTIVE Apolipoprotein E (ApoE) genotype is the strongest genetic risk factor for late-onset Alzheimer's disease, with the e4 allele increasing risk in a dose-dependent fashion. In addition to ApoE4 playing a crucial role in amyloid-β deposition,
Autor:
Cristian A Lasagna-Reeves, Maxime WC Rousseaux, Marcos J Guerrero-Muñoz, Jeehye Park, Paymaan Jafar-Nejad, Ronald Richman, Nan Lu, Urmi Sengupta, Alexandra Litvinchuk, Harry T Orr, Rakez Kayed, Huda Y Zoghbi
Publikováno v:
eLife, Vol 4 (2015)
Recent studies indicate that soluble oligomers drive pathogenesis in several neurodegenerative proteinopathies, including Alzheimer and Parkinson disease. Curiously, the same conformational antibody recognizes different disease-related oligomers, des
Externí odkaz:
https://doaj.org/article/50bd66d718644c13ad6bb20b07f4c12d
Autor:
Steven B. Zhang, David Maguire, Mei Zhang, Yeping Tian, Shanmin Yang, Amy Zhang, Katherine Casey-Sawicki, Deping Han, Jun Ma, Liangjie Yin, Yongson Guo, Xiaohui Wang, Chun Chen, Alexandra Litvinchuk, Zhenhuan Zhang, Steven Swarts, Sadasivan Vidyasagar, Lurong Zhang, Paul Okunieff
Publikováno v:
International Journal of Cell Biology, Vol 2014 (2014)
We investigated whether genetic radiosensitivity-related changes in mtDNA/nDNA ratios are significant to mitochondrial function and if a material effect on mtDNA content and function exists. BALB/c (radiosensitive), C57BL/6 (radioresistant), and F1 h
Externí odkaz:
https://doaj.org/article/37bd914f000b4aea8080a8a94a85ca27
Publikováno v:
J Clin Invest
Dysfunction of immune and vascular systems has been implicated in aging and Alzheimer disease; however, their interrelatedness remains poorly understood. The complement pathway is a well-established regulator of innate immunity in the brain. Here, we
Autor:
Wei Cao, Hui Zheng, Nicholas E. Propson, Ethan R. Roy, Alexandra Litvinchuk, Bianca Contreras
Publikováno v:
Innovation in Aging
Innate immunity has been implicated in normal aging, and age-related disease. The connection between age-related neuroinflammation and change in brain vasculature prior to disease onset remains poorly understood. The complement pathway is an establis
Publikováno v:
Alzheimer's & Dementia. 13
Autor:
Alexandra Litvinchuk, Ying Wooi Wan, Qian Wang, Fading Chen, Allysa L. Cole, Zhandong Liu, Nicholas E. Propson, Hui Zheng, Dan B. Swartzlander, Bin Zhang
Publikováno v:
Neuron. 100:1337-1353.e5
Summary Strong evidence implicates the complement pathway as an important contributor to amyloid pathology in Alzheimer’s disease (AD); however, the role of complement in tau modulation remains unclear. Here we show that the expression of C3 and C3
Autor:
A. G. Rogov, Dmitry A. Knorre, Svyatoslav S. Sokolov, Fedor F. Severin, Olga V. Markova, Alexandra Litvinchuk
Publikováno v:
European Journal of Cell Biology. 92:169-174
Stressed Saccharomyces cerevisiae cells easily lose respiratory function due to deletions in mitochondrial DNA, and this increases their general stress resistance. Is the loss active? We found that erythromycin (an inhibitor of mitochondrial translat
Autor:
Angie C.A. Chiang, Nadia Aithmitti, Joanna L. Jankowsky, Alexandra Litvinchuk, Hui Zheng, Hong Lian
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 36(2)
Increasing evidence supports a role of neuroinflammation in the pathogenesis of Alzheimer's disease (AD). Previously, we identified a neuron–glia signaling pathway whereby Aβ acts as an upstream activator of astroglial nuclear factor kappa B (NF-