Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Alexandra, Kupke"'
T-bet+ B cells are activated by and control endogenous retroviruses through TLR-dependent mechanisms
Autor:
Eileen Rauch, Timm Amendt, Aleksandra Lopez Krol, Fabian B. Lang, Vincent Linse, Michelle Hohmann, Ann-Christin Keim, Susanne Kreutzer, Kevin Kawengian, Malte Buchholz, Philipp Duschner, Saskia Grauer, Barbara Schnierle, Andreas Ruhl, Ingo Burtscher, Sonja Dehnert, Chege Kuria, Alexandra Kupke, Stephanie Paul, Thomas Liehr, Marcus Lechner, Markus Schnare, Andreas Kaufmann, Magdalena Huber, Thomas H. Winkler, Stefan Bauer, Philipp Yu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Endogenous retroviruses (ERVs) are an integral part of the mammalian genome. The role of immune control of ERVs in general is poorly defined as is their function as anti-cancer immune targets or drivers of autoimmune disease. Here, we genera
Externí odkaz:
https://doaj.org/article/614f814272ae48b086e1c7fdf428b850
Autor:
Anahita Fathi, Christine Dahlke, Verena Krähling, Alexandra Kupke, Nisreen M. A. Okba, Matthijs P. Raadsen, Jasmin Heidepriem, Marcel A. Müller, Grigori Paris, Susan Lassen, Michael Klüver, Asisa Volz, Till Koch, My L. Ly, Monika Friedrich, Robert Fux, Alina Tscherne, Georgia Kalodimou, Stefan Schmiedel, Victor M. Corman, Thomas Hesterkamp, Christian Drosten, Felix F. Loeffler, Bart L. Haagmans, Gerd Sutter, Stephan Becker, Marylyn M. Addo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
In a clinical trial, Fathi et al. show that a booster vaccination with a vector vaccine candidate against the highly pathogenic Middle East Respiratory Syndrome coronavirus is safe and strongly improves the immunity generated by primary immunization.
Externí odkaz:
https://doaj.org/article/9c0741a645df4990aa04ffff02338df4
Autor:
Christian Meyer zu Natrup, Alina Tscherne, Christine Dahlke, Malgorzata Ciurkiewicz, Dai-Lun Shin, Anahita Fathi, Cornelius Rohde, Georgia Kalodimou, Sandro Halwe, Leonard Limpinsel, Jan H. Schwarz, Martha Klug, Meral Esen, Nicole Schneiderhan-Marra, Alex Dulovic, Alexandra Kupke, Katrin Brosinski, Sabrina Clever, Lisa-Marie Schünemann, Georg Beythien, Federico Armando, Leonie Mayer, Marie L. Weskamm, Sylvia Jany, Astrid Freudenstein, Tamara Tuchel, Wolfgang Baumgärtner, Peter Kremsner, Rolf Fendel, Marylyn M. Addo, Stephan Becker, Gerd Sutter, Asisa Volz
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 24 (2022)
The SARS-CoV-2 spike (S) glycoprotein is synthesized as a large precursor protein and must be activated by proteolytic cleavage into S1 and S2. A recombinant modified vaccinia virus Ankara (MVA) expressing native, full-length S protein (MVA-SARS-2-S)
Externí odkaz:
https://doaj.org/article/c3dacfdcee5044c4a6d220158af4b33c
Autor:
Georgia Kalodimou, Sylvia Jany, Astrid Freudenstein, Jan Hendrik Schwarz, Leonard Limpinsel, Cornelius Rohde, Alexandra Kupke, Stephan Becker, Asisa Volz, Alina Tscherne, Gerd Sutter
Publikováno v:
Viruses, Vol 15, Iss 5, p 1180 (2023)
The COVID-19 pandemic caused significant human health and economic consequences. Due to the ability of SARS-CoV-2 to spread rapidly and to cause severe disease and mortality in certain population groups, vaccines are essential for controlling the pan
Externí odkaz:
https://doaj.org/article/1273b01d73fc4963ac4a077943276725
Autor:
Xuying Zhang, Marc Hirschfeld, Julia Beck, Alexandra Kupke, Kernt Köhler, Ekkehard Schütz, Bertram Brenig
Publikováno v:
Veterinary Quarterly, Vol 40, Iss 1, Pp 58-67 (2020)
Background Neuromusculoskeletal anomalies generally in combination with severe clinical symptoms, comprise a heterogeneous group of fairly common and mostly fatal disorders in man and animals. Osteogenesis imperfecta (OI), also known as brittle bone
Externí odkaz:
https://doaj.org/article/88dc0545da9246c083ff8a608fe869bd
Autor:
Alexandra Kupke, Asisa Volz, Erik Dietzel, Astrid Freudenstein, Jörg Schmidt, Hosam Shams-Eldin, Sylvia Jany, Lucie Sauerhering, Verena Krähling, Michelle Gellhorn Serra, Christiane Herden, Markus Eickmann, Stephan Becker, Gerd Sutter
Publikováno v:
Vaccines, Vol 10, Iss 4, p 533 (2022)
The urgent need for vaccines against Ebola virus (EBOV) was underscored by the large outbreak in West Africa (2014–2016). Since then, several promising vaccine candidates have been tested in pre-clinical and clinical studies. As a result, two vacci
Externí odkaz:
https://doaj.org/article/c197fefc32064d6e8959d5b89150555f
Autor:
Sandro Halwe, Alexandra Kupke, Kanika Vanshylla, Falk Liberta, Henning Gruell, Matthias Zehner, Cornelius Rohde, Verena Krähling, Michelle Gellhorn Serra, Christoph Kreer, Michael Klüver, Lucie Sauerhering, Jörg Schmidt, Zheng Cai, Fei Han, David Young, Guangwei Yang, Marek Widera, Manuel Koch, Anke Werner, Lennart Kämper, Nico Becker, Michael S. Marlow, Markus Eickmann, Sandra Ciesek, Felix Schiele, Florian Klein, Stephan Becker
Publikováno v:
Viruses, Vol 13, Iss 8, p 1498 (2021)
Despite the recent availability of vaccines against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), there is an urgent need for specific anti-SARS-CoV-2 drugs. Monoclonal neutralizing antibodies are an important drug class in the g
Externí odkaz:
https://doaj.org/article/a952a8244dfc4b74bafbb2519784edf5
Autor:
Lucie Sauerhering, Irina Kuznetsova, Alexandra Kupke, Lars Meier, Sandro Halwe, Cornelius Rohde, Jörg Schmidt, Rory E. Morty, Olga Danov, Armin Braun, István Vadász, Stephan Becker, Susanne Herold
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 205:964-968
Autor:
Verena Krähling, Stephanie Erbar, Alexandra Kupke, Sara S. Nogueira, Kerstin C. Walzer, Hendrik Berger, Erik Dietzel, Sandro Halwe, Cornelius Rohde, Lucie Sauerhering, Letícia Aragão-Santiago, Jorge Moreno Herrero, Sonja Witzel, Heinrich Haas, Stephan Becker, Ugur Sahin
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy.
Emerging and re-emerging viruses, such as Zaire Ebola virus (EBOV), pose a global threat and require immediate countermeasures, including the rapid development of effective vaccines that are easy to manufacture. Synthetic self-amplifying RNAs (saRNAs
Autor:
Aileen Ebenig, Samada Muraleedharan, Julia Kazmierski, Daniel Todt, Arne Auste, Martina Anzaghe, André Gömer, Dylan Postmus, Patricia Gogesch, Marc Niles, Roland Plesker, Csaba Miskey, Michelle Gellhorn Serra, Angele Breithaupt, Cindy Hörner, Carina Kruip, Rosina Ehmann, Zoltan Ivics, Zoe Waibler, Stephanie Pfaender, Emanuel Wyler, Markus Landthaler, Alexandra Kupke, Geraldine Nouailles, Christine Goffinet, Richard J.P. Brown, Michael D. Mühlebach
Vaccine-associated enhanced respiratory disease (VAERD) is a severe complication for some respiratory infections. To investigate the potential for VAERD induction in coronavirus disease 2019 (COVID-19), we evaluate two vaccine leads utilizing a sever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27466db8ae8b4532e40612e5d44b512d
http://edoc.mdc-berlin.de/22013/7/22013suppl.zip
http://edoc.mdc-berlin.de/22013/7/22013suppl.zip