Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Alexandra, Kretz"'
Autor:
Daniela Gerovska, Julie B. Noer, Yating Qin, Quratul Ain, Donjetë Januzi, Matthias Schwab, Otto W. Witte, Marcos J. Araúzo-Bravo, Alexandra Kretz
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-25 (2023)
Abstract Background Numerous genes, including SOD1, mutated in familial and sporadic amyotrophic lateral sclerosis (f/sALS) share a role in DNA damage and repair, emphasizing genome disintegration in ALS. One possible outcome of chromosomal instabili
Externí odkaz:
https://doaj.org/article/2b6b96ec495247b185cba7c323cca0f6
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 5, Pp 1411-1413 (2025)
Externí odkaz:
https://doaj.org/article/2354572d26f04bd9926cd14a4f1149b1
Publikováno v:
Neural Regeneration Research, Vol 13, Iss 2, Pp 173-180 (2018)
The pathophysiology of amyotrophic lateral sclerosis (ALS) is particularly challenging due to the heterogeneity of its clinical presentation and the diversity of cellular, molecular and genetic peculiarities involved. Molecular insights unveiled seve
Externí odkaz:
https://doaj.org/article/5783e0cadf284ad7ba934c59c5bac2f2
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183684 (2017)
Mutations in the human Cu/Zn superoxide dismutase type-1 (hSOD1) gene are common in familial amyotrophic lateral sclerosis (fALS). The pathophysiology has been linked to, e.g., organelle dysfunction, RNA metabolism and oxidative DNA damage conferred
Externí odkaz:
https://doaj.org/article/2620469c81a349998724c3f71e7dc42b
Publikováno v:
Cells, Vol 8, Iss 11, p 1446 (2019)
In contrast to the programmed nature of development, it is still a matter of debate whether aging is an adaptive and regulated process, or merely a consequence arising from a stochastic accumulation of harmful events that culminate in a global state
Externí odkaz:
https://doaj.org/article/2dd2afabe03e4ea7b920a2b2f05ab5d0
Autor:
Quratul, Ain, Christian W, Schmeer, Diane, Wengerodt, Yvonne, Hofmann, Otto W, Witte, Alexandra, Kretz
Publikováno v:
International journal of molecular sciences. 23(6)
Efficient purification of viable neural cells from the mature CNS has been historically challenging due to the heterogeneity of the inherent cell populations. Moreover, changes in cellular interconnections, membrane lipid and cholesterol compositions
Publikováno v:
Neurobiology of Disease, Vol 21, Iss 2, Pp 421-430 (2006)
Heat shock proteins (Hsps) are stress proteins that mediate protein stabilization in various tissues and protect cells from environmental stress. Novel evidence suggests that overexpression of the small heat shock protein 27 (Hsp27) in neurons protec
Externí odkaz:
https://doaj.org/article/aed871ee94a14296a1543c540871dafe
Autor:
Guido Straten, Christian Schmeer, Alexandra Kretz, Ellen Gerhardt, Sebastian Kügler, Jörg B. Schulz, Claude Gravel, Mathias Bähr, Stefan Isenmann
Publikováno v:
Neurobiology of Disease, Vol 11, Iss 1, Pp 123-133 (2002)
Following transection of the optic nerve (ON) in the adult rat, retinal ganglion cells (RGCs) undergo degeneration, and within 14 days 85% of axotomized RGCs die by apoptosis. Adenoviral delivery of the mammalian caspase inhibitor X-chromosome-linked
Externí odkaz:
https://doaj.org/article/f54dbb76051244d1b560be297a2bf8da
Autor:
Emanuel, Barth, Akash, Srivastava, Diane, Wengerodt, Milan, Stojiljkovic, Hubertus, Axer, Otto W, Witte, Alexandra, Kretz, Manja, Marz
Publikováno v:
Aging (Albany NY)
The circadian clock system influences the biology of life by establishing circadian rhythms in organisms, tissues, and cells, thus regulating essential biological processes based on the day/night cycle. Circadian rhythms change over a lifetime due to
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 2477, p 2477 (2020)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Still unresolved is the question of how a lifetime accumulation of somatic gene copy number alterations impact organ functionality and aging and age-related pathologies. Such an issue appears particularly relevant in the broadly post-mitotic central