ML355 Modulates Platelet Activation and Prevents ABT-737 Induced Apoptosis in Platelets

Autor: Valentina Shpakova, Natalia Rukoyatkina, Nada Al Arawe, Anna Prilepskaya, Alexandra Kharazova, Iraida Sharina, Stepan Gambaryan, Emil Martin

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 381:164-175

12-lipoxigenase (12-LOX) is implicated in regulation of platelet activation processes and can be a new promising target for antiplatelet therapy. However, investigations of 12-LOX were restricted by the lack of specific and potent 12-LOX inhibitors a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79f09380f61085a1ebfb4be938cfa162
https://doi.org/10.1124/jpet.121.000973

Curcumin by activation of adenosine A

Autor: Natalia, Rukoyatkina, Valentina, Shpakova, Alina, Bogoutdinova, Alexandra, Kharazova, Igor, Mindukshev, Stepan, Gambaryan

Publikováno v: Biochemical and biophysical research communications. 586

Curcumin is a natural polyphenol derived from the turmeric plant (Curcuma longa) which exhibits numerous beneficial effects on different cell types. Inhibition of platelet activation by curcumin is well known, however molecular mechanisms of its acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::54deb5ed87577e32cafebd17119fc211
https://pubmed.ncbi.nlm.nih.gov/34823218

Time-lapse microscopic observation of non-dividing cells in cultured human osteosarcoma MG-63 cell line

Autor: Alexander Kofman, Tori Houwman, Bart van Knippenberg, Kai Ding, Carl A. Gregory, Marissa Soderberg, Cal Wiese, Alexandra Kharazova, John L. Collins, Elise Hadley, John Dosch

Publikováno v: Cell Cycle. 17:174-181

Cancer stem cells resemble normal tissue-specific stem cells in many aspects, such as self-renewal and plasticity. Like their non-malignant counterparts, cancer stem cells are suggested to exhibit a relative quiescence. The established cancer cell li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d67753532f9fc61ccdc3b45743df6bf
https://doi.org/10.1080/15384101.2017.1395535

Identification and characterization of a chitin-binding protein purified from coelomic fluid of the lugworm Arenicola marina defining a novel protein sequence family

Autor: Jesper B. Moeller, Anders Schlosser, Anthony C. Willis, Uffe Holmskov, Grith Lykke Sørensen, Karsten Skjødt, Lars Vitved, Rikke Leth-Larsen, Alexandra Kharazova, Ida Tornøe, Nina Vitashenkova, Kit Peiter Lund, Søren Hansen

Publikováno v: Vitashenkova, N, Moeller, J B, Leth-Larsen, R, Schlosser, A, Lund, K P, Tornøe, I, Vitved, L, Hansen, S, Willis, A, Kharazova, A D, Skjødt, K, Sorensen, G L & Holmskov, U 2012, ' Identification and characterization of a chitin-binding protein purified from coelomic fluid of the lugworm Arenicola marina defining a novel protein sequence family ', Journal of Biological Chemistry, vol. 287, pp. 42846-42855 . https://doi.org/10.1074/jbc.M112.420976

We have isolated a novel type of lectin named Arenicola marina lectin-1 (AML-1) from the lugworm A. marina. The lectin was purified from the coelomic fluid by affinity chromatography on a GlcNAc-derivatized column and eluted with GlcNAc. On SDS-PAGE,

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https://pubmed.ncbi.nlm.nih.gov/23115230

HIV-1 gag expression is quantitatively dependent on the ratio of native and optimized codons

Autor: Alexander, Kofman, Marcus, Graf, Alexandra, Bojak, Ludwig, Deml, Kurt, Bieler, Alexandra, Kharazova, Hans, Wolf, Ralf, Wagner

Publikováno v: Tsitologiia. 45(1)

There is a significant variation of codon usage bias among different species and even among genes within the same organisms. Codon optimization, this is, gene redesigning with the use of codons preferred for the specific expression system, results in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9049408a06e131072cd06994ed104e46
https://pubmed.ncbi.nlm.nih.gov/12683241