Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Alexandra, Gruss"'
Autor:
Paprapach Wongdontree, Aaron Millan-Oropeza, Jennifer Upfold, Jean-Pierre Lavergne, David Halpern, Clara Lambert, Adeline Page, Gérald Kénanian, Christophe Grangeasse, Céline Henry, Agnès Fouet, Karine Gloux, Jamila Anba-Mondoloni, Alexandra Gruss
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109505- (2024)
Summary: Antibiotics inhibiting the fatty acid synthesis pathway (FASII) of the major pathogen Staphylococcus aureus reach their enzyme targets, but bacteria continue growth by using environmental fatty acids (eFAs) to produce phospholipids. We asses
Externí odkaz:
https://doaj.org/article/f6bf5f3ca6be4f448560f85bfcc04fd3
Autor:
David Halpern, Claire Morvan, Aurélie Derré-Bobillot, Thierry Meylheuc, Mélanie Guillemet, Sylvie Rabot, Alexandra Gruss
Publikováno v:
mSphere, Vol 6, Iss 3 (2021)
Aerobic bacteria are frequent primocolonizers of the human naive intestine. Their generally accepted role is to eliminate oxygen, which would allow colonization by anaerobes that subsequently dominate bacterial gut populations.
Externí odkaz:
https://doaj.org/article/9799f60a91994ce3af9b045e6557bf14
Autor:
Amit Pathania, Jamila Anba-Mondoloni, Myriam Gominet, David Halpern, Julien Dairou, Laëtitia Dupont, Gilles Lamberet, Patrick Trieu-Cuot, Karine Gloux, Alexandra Gruss
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
Staphylococcus aureus
Externí odkaz:
https://doaj.org/article/cfec7281be284fa7a98f1d826099d4d4
Autor:
Alexandra Gruss
Publikováno v:
PLoS Genetics, Vol 16, Iss 7, p e1008842 (2020)
Externí odkaz:
https://doaj.org/article/9b470a986a7c436c9ceefcfb35dcc4e9
Autor:
Gérald Kénanian, Claire Morvan, Antonin Weckel, Amit Pathania, Jamila Anba-Mondoloni, David Halpern, Marine Gaillard, Audrey Solgadi, Laetitia Dupont, Céline Henry, Claire Poyart, Agnès Fouet, Gilles Lamberet, Karine Gloux, Alexandra Gruss
Publikováno v:
Cell Reports, Vol 29, Iss 12, Pp 3974-3982.e4 (2019)
Summary: The essentiality of fatty acid synthesis (FASII) products in the human pathogen Staphylococcus aureus is the underlying rationale for FASII-targeted antimicrobial drug design. Reports of anti-FASII efficacy in animals support this choice. Ho
Externí odkaz:
https://doaj.org/article/b5cad4a0e4ec4316bfa82390590c6c71
Autor:
Claire Morvan, David Halpern, Gérald Kénanian, Constantin Hays, Jamila Anba-Mondoloni, Sophie Brinster, Sean Kennedy, Patrick Trieu-Cuot, Claire Poyart, Gilles Lamberet, Karine Gloux, Alexandra Gruss
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
The bacterial pathway for fatty acid biosynthesis, FASII, is a target for development of new anti-staphylococcal drugs. Here, Morvan et al. show that exogenous fatty acids can favour the emergence of staphylococcal strains displaying resistance to mu
Externí odkaz:
https://doaj.org/article/e8d21997597244098908c235c4491102
Publikováno v:
Microbiol Mol Biol Rev
Phospholipids are vital membrane constituents that determine cell functions and interactions with the environment. For bacterial pathogens, rapid adjustment of phospholipid composition to changing conditions during infection can be crucial for growth
Autor:
Paprapach Wongdontree, Aaron Millan-Oropeza, Jennifer Upfold, Jean-Pierre Lavergne, David Halpern, Karine Gloux, Adeline Page, Gérald Kénanian, Christophe Grangeasse, Céline Henry, Jamila Anba-Mondoloni, Alexandra Gruss
A crucial step in antimicrobial development pipelines is proof of functionality in the host environment. Antibiotics targeting fatty acid synthesis (FASII) of the major pathogen Staphylococcus aureus actively inhibit FASII but do not prevent in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3996cc46d88bba26160e71ef90742029
https://doi.org/10.1101/2022.09.09.506511
https://doi.org/10.1101/2022.09.09.506511
Autor:
Byang Zhou, Amit Pathania, Deepak Pant, David Halpern, Philippe Gaudu, Patrick Trieu-Cuot, Alexandra Gruss, Karine Gloux
Lipids are essential components of bacterial membranes and phages are quasi-ubiquitous in bacteria. In the human pathogenStaphylococcus aureus, two common prophages ϕ13 and ϕ11.1 are preferentially integrated in lipase genes, and act as regulatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eb111a5e2da8df124a730dae137a0b8
https://doi.org/10.1101/2022.01.27.478126
https://doi.org/10.1101/2022.01.27.478126
Publikováno v:
Applied and Environmental Microbiology
Acetoin, 3-hydroxyl,2-butanone, is extensively used as a flavor additive in food products. This volatile compound is produced by the dairy bacterium Lactococcus lactis when aerobic respiration is activated by haem addition, and comprises ∼70% of ca