Molecular requirements for the inter-subunit interaction and kinetochore recruitment of SKAP and Astrin

Autor: Alexandra Friese, Alex C. Faesen, Pim J. Huis in ‘t Veld, Josef Fischböck, Daniel Prumbaum, Arsen Petrovic, Stefan Raunser, Franz Herzog, Andrea Musacchio

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)

SKAP and Astrin form a heterodimer that localizes to spindle microtubules and to mature microtubule-kinetochore attachments during mitosis. Here, the authors identify molecular requirements for the inter-subunit interaction of SKAP and Astrin and kin

Externí odkaz: https://doaj.org/article/166e11b186344cc996360ea2d3c1a08b

Development of a PDEδ‐Targeting PROTACs that Impair Lipid Metabolism

Autor: Michael Winzker, Alexandra Friese, Uwe Koch, Petra Janning, Slava Ziegler, Herbert Waldmann

Publikováno v: Angewandte Chemie. 132:5644-5650

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c6922f4a5d34a66827948ffd212f661c
https://doi.org/10.1002/ange.201913904

The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis

Autor: Ingrid R. Vetter, Dale Corkery, Luca Laraia, Nelli Erwin, Herbert Waldmann, Maja Köhn, Pablo Rios-Munoz, Roland Winter, Mridula Dwivedi, Walter Hofer, Lei Li, Yao-Wen Wu, Malte Metz, Beate Schölermann, Andreas Brockmeyer, Laura Klewer, Alexandra Friese, Petra Janning, Hacer Karatas, Georgios Konstantinidis, Slava Ziegler

Publikováno v: Nature Chemical Biology
Laraia, L, Friese, A, Corkery, D P, Konstantinidis, G, Erwin, N, Hofer, W, Karatas, H, Klewer, L, Brockmeyer, A, Metz, M, Schölermann, B, Dwivedi, M, Li, L, Rios-Munoz, P, Köhn, M, Winter, R, Vetter, I R, Ziegler, S, Janning, P, Wu, Y W & Waldmann, H 2019, ' The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis ', Nature Chemical Biology, vol. 15, no. 7, pp. 710-720 . https://doi.org/10.1038/s41589-019-0307-5

Autophagy mediates the degradation of damaged proteins, organelles and pathogens, and plays a key role in health and disease. Thus, the identification of new mechanisms involved in the regulation of autophagy is of major interest. In particular, litt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6765c89454ca57ec6764c54a0bf42a5
https://doi.org/10.1038/s41589-019-0307-5

Discovery of a σ1 receptor antagonist by combination of unbiased cell painting and thermal proteome profiling

Autor: Francisco R. Nieto, Hiroyuki Osada, Nobumoto Watanabe, Herbert Waldmann, Bernhard Wünsch, Hao Xu, Antonia Artacho-Cordón, Alexandra Brause, Malte Metz, Slava Ziegler, Dirk Schepmann, Tatsuro Kawamura, Alexandra Friese, Julian Wilke

Publikováno v: Cell Chemical Biology. 28:848-854.e5

Phenotypic screening for bioactive small molecules is typically combined with affinity-based chemical proteomics to uncover the respective molecular targets. However, such assays and the explored bioactivity are biased toward the monitored phenotype,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80233852a94f640e2a0df9f993669921
https://doi.org/10.1016/j.chembiol.2021.01.009

The Convergence of Stem Cell Technologies and Phenotypic Drug Discovery

Autor: Andrei Ursu, Hans R. Schöler, Herbert Waldmann, Andreas Hochheimer, Jan M. Bruder, Alexandra Friese

Publikováno v: Cell Chemical Biology

Recent advances in induced pluripotent stem cell technologies and phenotypic screening shape the future of bioactive small-molecule discovery. In this review we analyze the impact of small-molecule phenotypic screens on drug discovery as well as on t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff325178a52883e924dd83c7be6b4e22
https://hdl.handle.net/21.11116/0000-0003-DCD8-221.11116/0000-0003-DCDA-0