Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Alexandra, Brause"'
Autor:
Jana Flegel, Saad Shaaban, Zhi Jun Jia, Britta Schulte, Yilong Lian, Adrian Krzyzanowski, Malte Metz, Tabea Schneidewind, Fabian Wesseler, Anke Flegel, Alisa Reich, Alexandra Brause, Gang Xue, Minghao Zhang, Lara Dötsch, Isabelle D. Stender, Jan-Erik Hoffmann, Rebecca Scheel, Petra Janning, Fraydoon Rastinejad, Dennis Schade, Carsten Strohmann, Andrey P. Antonchick, Sonja Sievers, Pedro Moura-Alves, Slava Ziegler, Herbert Waldmann
Publikováno v:
Journal of Medicinal Chemistry. 65:16268-16289
Identification and analysis of small molecule bioactivity in target-agnostic cellular assays and monitoring changes in phenotype followed by identification of the biological target are a powerful approach for the identification of novel bioactive che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be09301612a26f71d7b6806277269021
https://doi.org/10.1021/acs.jmedchem.2c00956
https://doi.org/10.1021/acs.jmedchem.2c00956
Autor:
Jessica Wagner, Tabea Schneidewind, Alexandra Brause, Herbert Waldmann, Alexandra Friese, Srinivasa Rao Vidadala, Petra Janning, Shobhna Kapoor, Matthias Bischoff, Juhi Sardana, Slava Ziegler, Tim Förster
Publikováno v:
Angewandte Chemie International Edition. 58:13009-13013
Cell-based screening is a powerful approach to identify novel chemical modulators and biological components of relevant biological processes. The canonical Wnt pathway is essential for normal embryonic development and tissue homeostasis, and its dere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f37240f5410a4e1fb917fc2dab2532
https://doi.org/10.1002/anie.201905977
https://doi.org/10.1002/anie.201905977
Autor:
Julian, Wilke, Tatsuro, Kawamura, Hao, Xu, Alexandra, Brause, Alexandra, Friese, Malte, Metz, Dirk, Schepmann, Bernhard, Wünsch, Antonia, Artacho-Cordón, Francisco R, Nieto, Nobumoto, Watanabe, Hiroyuki, Osada, Slava, Ziegler, Herbert, Waldmann
Publikováno v:
Cell chemical biology. 28(6)
Phenotypic screening for bioactive small molecules is typically combined with affinity-based chemical proteomics to uncover the respective molecular targets. However, such assays and the explored bioactivity are biased toward the monitored phenotype,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9b81aca241df801c6c805c5921000eb8
https://pubmed.ncbi.nlm.nih.gov/33567254
https://pubmed.ncbi.nlm.nih.gov/33567254
Autor:
Tom Mejuch, Annina Burhop, Alexandra Brause, Slava Ziegler, Tabea Schneidewind, Herbert Waldmann, Sonja Sievers, Axel Pahl
Publikováno v:
Chembiochem
Unbiased morphological profiling of bioactivity, for example, in the cell painting assay (CPA), enables the identification of a small molecule's mode of action based on its similarity to the bioactivity of reference compounds, irrespective of the bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a996402655715cdd82ccc061c0c4655
https://pubmed.ncbi.nlm.nih.gov/32618075
https://pubmed.ncbi.nlm.nih.gov/32618075
Autor:
Francisco R. Nieto, Hiroyuki Osada, Nobumoto Watanabe, Herbert Waldmann, Bernhard Wünsch, Hao Xu, Antonia Artacho-Cordón, Alexandra Brause, Malte Metz, Slava Ziegler, Dirk Schepmann, Tatsuro Kawamura, Alexandra Friese, Julian Wilke
Publikováno v:
Cell Chemical Biology. 28:848-854.e5
Phenotypic screening for bioactive small molecules is typically combined with affinity-based chemical proteomics to uncover the respective molecular targets. However, such assays and the explored bioactivity are biased toward the monitored phenotype,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80233852a94f640e2a0df9f993669921
https://doi.org/10.1016/j.chembiol.2021.01.009
https://doi.org/10.1016/j.chembiol.2021.01.009
Autor:
Elisabeth Hennes, Herbert Waldmann, Jana Flegel, Ivana Mejdrová, Slava Ziegler, Radim Nencka, Matthias Baumann, Andrei Ursu, Takanari Inoue, Yuta Nihongaki, Lucas Robke, Petra Janning, Hideaki Matsubayashi, Jared Sterneckert, Alexandra Brause, Jan Eickhoff, Lea Kremer, Hans R. Schöler, Susanne Kordes
Publikováno v:
Angewandte Chemie (International Ed. in English)
The Hedgehog (Hh) signaling pathway is crucial for vertebrate embryonic development, tissue homeostasis and regeneration. Hh signaling is upregulated in basal cell carcinoma and medulloblastoma and Hh pathway inhibitors targeting the Smoothened (SMO)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::219c5577a79ba609e8dfc96f5c7d11dd
https://pubmed.ncbi.nlm.nih.gov/31454140
https://pubmed.ncbi.nlm.nih.gov/31454140
Autor:
Tom Mejuch, Herbert Waldmann, Tabea Schneidewind, Axel Pahl, Alexandra Brause, Slava Ziegler, Annina Burhop, Sonja Sievers
Publikováno v:
ChemBioChem. 21:3160-3160
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::385abdbf6cd364def2d1c14f6c3886fc
https://doi.org/10.1002/cbic.202000734
https://doi.org/10.1002/cbic.202000734