Výsledky vyhledávání - "Alexandr Kristian"

Akademický článek

Liver X receptors induce antiproliferative effects in basal‐like breast cancer

Autor: Mads Haugland Haugen, Hedda von der Lippe Gythfeldt, Eivind Valen Egeland, Lisa Svartdal Normann, Abhilash D. Pandya, Lise‐Lotte Vedin, Siri Juell, Ellen Tenstad, Geir Frode Øy, Alexandr Kristian, Elisabetta Marangoni, Therese Sørlie, Knut Steffensen, Gunhild Mari Mælandsmo, Olav Engebraaten

Publikováno v: Molecular Oncology, Vol 17, Iss 10, Pp 2041-2055 (2023)

Liver X receptors (LXRs) are nuclear transcription factors important in the regulation of cholesterol transport, and glucose and fatty acid metabolism. The antiproliferative role of LXRs has been studied in a variety of malignancies and may represent

Externí odkaz: https://doaj.org/article/f082ee37ad4f4724ba7aa48e46c2a756

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Akademický článek

Ultra-early changes in vascular parameters from dynamic contrast enhanced MRI of breast cancer xenografts following systemic therapy with doxorubicin and liver X receptor agonist

Autor: Kathinka E. Pitman, Kine M. Bakke, Alexandr Kristian, Eirik Malinen

Publikováno v: Cancer Imaging, Vol 19, Iss 1, Pp 1-7 (2019)

Abstract Background Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) may be used to depict tumour vascular structure and for therapy response assessment in various tumour sites. The purpose of the current work is to examine whether ultr

Externí odkaz: https://doaj.org/article/a71120ab1a8348d89eaefa4fcbed0a10

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Akademický článek

STAMP2 increases oxidative stress and is critical for prostate cancer

Publikováno v: EMBO Molecular Medicine, Vol 7, Iss 3, Pp 315-331 (2015)

Abstract The six transmembrane protein of prostate 2 (STAMP2) is an androgen‐regulated gene whose mRNA expression is increased in prostate cancer (PCa). Here, we show that STAMP2 protein expression is increased in human PCa compared with benign pro

Externí odkaz: https://doaj.org/article/4aeac316ce514471a35047b46240bd93

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Akademický článek

Longitudinal Magnetic Resonance Imaging-Based Assessment of Vascular Changes and Radiation Response in Androgen-Sensitive Prostate Carcinoma Xenografts under Androgen-Exposed and Androgen-Deprived Conditions

Autor: Kathrine Røe, Therese Seierstad, Alexandr Kristian, Lars Tore Gyland Mikalsen, Gunhild Mari Mælandsmo, Albert J. van der Kogel, Anne Hansen Ree, Dag Rune Olsen

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 10, Pp 818-825 (2010)

Prostate cancer (PCa) patients receive androgen-deprivation therapy (ADT) to reduce tumor burden. However, complete eradication of PCa is unusual, and recurrent disease is evident within approximately 2 years in high-risk patients. Clinical evidence

Externí odkaz: https://doaj.org/article/581af3c793dc47b295cd5e434d654a2c

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Akademický článek

Differential in vivo tumorigenicity of distinct subpopulations from a luminal-like breast cancer xenograft.

Autor: Nirma Skrbo, Geir-Olav Hjortland, Alexandr Kristian, Ruth Holm, Silje Nord, Lina Prasmickaite, Olav Engebraaten, Gunhild M Mælandsmo, Therese Sørlie, Kristin Andersen

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e113278 (2014)

Intratumor heterogeneity caused by genetic, phenotypic or functional differences between cancer cell subpopulations is a considerable clinical challenge. Understanding subpopulation dynamics is therefore central for both optimization of existing ther

Externí odkaz: https://doaj.org/article/d41254c43b5e469591882c0ff60b9d0e

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Akademický článek

Aldehyde dehydrogenase (ALDH) activity does not select for cells with enhanced aggressive properties in malignant melanoma.

Autor: Lina Prasmickaite, Birgit Ø Engesaeter, Nirma Skrbo, Tina Hellenes, Alexandr Kristian, Nina K Oliver, Zhenhe Suo, Gunhild M Maelandsmo

Publikováno v: PLoS ONE, Vol 5, Iss 5, p e10731 (2010)

BACKGROUND: Malignant melanoma is an exceptionally aggressive, drug-resistant and heterogeneous cancer. Recently it has been shown that melanoma cells with high clonogenic and tumourigenic abilities are common, but markers distinguishing such cells f

Externí odkaz: https://doaj.org/article/ebc2aacb6b2a40d3bd999b9794365f0b

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Akademický článek

Validation and use of microdialysis for determination of pharmacokinetic properties of the chemotherapeutic agent mitomycin C - an experimental study

Autor: Sørensen Olaf, Andersen Anders, Olsen Harald, Alexandr Kristian, Ekstrøm Per Olaf, Giercksky Karl-Erik, Flatmark Kjersti

Publikováno v: BMC Cancer, Vol 10, Iss 1, p 469 (2010)

Abstract Background Mitomycin C is a chemotherapeutic agent used in the treatment of peritoneal surface malignancies, administered as hyperthermic intraperitoneal chemotherapy after cytoreductive surgery. Pharmacokinetic studies have been based on an

Externí odkaz: https://doaj.org/article/507c8ef526c84898a4ac065140d0bba0

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