Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Alexander-Thomas Hauser"'
Autor:
Hugo Rolando Vaca, Ana María Celentano, María Agustina Toscanini, Tino Heimburg, Ehab Ghazy, Patrik Zeyen, Alexander-Thomas Hauser, Guilherme Oliveira, María Celina Elissondo, Manfred Jung, Wolfgang Sippl, Federico Camicia, Mara Cecilia Rosenzvit
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009226 (2021)
BackgroundEchinococcosis and cysticercosis are neglected tropical diseases caused by cestode parasites (family Taeniidae). Not only there is a small number of approved anthelmintics for the treatment of these cestodiases, but also some of them are no
Externí odkaz:
https://doaj.org/article/4e0617f643d64ddcac83ccd16c054427
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
The cell type diversity and complexity of the nervous system is generated by a network of signaling events, transcription factors, and epigenetic regulators. Signaling and transcriptional control have been easily amenable to forward genetic screens i
Externí odkaz:
https://doaj.org/article/7f19328e4ff5424f893db77d7bd2d223
Autor:
Janina Schreiber, Nastassia Liaukouskaya, Lars Fuhrmann, Alexander-Thomas Hauser, Manfred Jung, Tobias B. Huber, Nicola Wanner
Publikováno v:
Biomedicines, Vol 9, Iss 12, p 1878 (2021)
In utero renal development is subject to maternal metabolic and environmental influences affecting long-term renal function and the risk of developing chronic kidney failure and cardiovascular disease. Epigenetic processes have been implicated in the
Externí odkaz:
https://doaj.org/article/04c8d27eae8f491e94141b11d81c992f
Autor:
Lars Fuhrmann, Saskia Lindner, Alexander-Thomas Hauser, Clemens Höse, Oliver Kretz, Clemens D. Cohen, Maja T. Lindenmeyer, Wolfgang Sippl, Manfred Jung, Tobias B. Huber, Nicola Wanner
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8, p 4157 (2021)
A growing body of evidence suggests that low nephron numbers at birth can increase the risk of chronic kidney disease or hypertension later in life. Environmental stressors, such as maternal malnutrition, medication and smoking, can influence renal s
Externí odkaz:
https://doaj.org/article/8b44b09d8f1942a7a4829dc34ba22779
Publikováno v:
Molecules, Vol 23, Iss 2, p 321 (2018)
We designed and synthesized carbamates of the clinically-approved HDAC (histone deacetylase) inhibitor vorinostat (suberoylanilide hydroxamic acid, SAHA) in order to validate our previously-proposed hypothesis that these carbamates might serve as pro
Externí odkaz:
https://doaj.org/article/ce7eb99fc923401790dda4ab8c128389
Autor:
Martin Marek, Srinivasaraghavan Kannan, Alexander-Thomas Hauser, Marina Moraes Mourão, Stéphanie Caby, Vincent Cura, Diana A Stolfa, Karin Schmidtkunz, Julien Lancelot, Luiza Andrade, Jean-Paul Renaud, Guilherme Oliveira, Wolfgang Sippl, Manfred Jung, Jean Cavarelli, Raymond J Pierce, Christophe Romier
Publikováno v:
PLoS Pathogens, Vol 9, Iss 9, p e1003645 (2013)
The treatment of schistosomiasis, a disease caused by blood flukes parasites of the Schistosoma genus, depends on the intensive use of a single drug, praziquantel, which increases the likelihood of the development of drug-resistant parasite strains a
Externí odkaz:
https://doaj.org/article/8177e77a4c194daa95e03dd903b2b7f5
Autor:
Hugo Rolando Vaca, Ana María Celentano, María Agustina Toscanini, Alexander-Thomas Hauser, Natalia Macchiaroli, María Luján Cuestas, Alejandro David Nusblat, Wolfgang Sippl, María Celina Elissondo, Manfred Jung, Federico Camicia, Mara Cecilia Rosenzvit
Publikováno v:
International journal for parasitology. 52(5)
Anti-parasitic treatment of neglected tropical diseases caused by cestodes such as echinococcosis and cysticercosis relies on a small number of approved anthelmintic drugs. Furthermore, the treatment is usually prolonged and often partially effective
Autor:
Maja T. Lindenmeyer, Lars Fuhrmann, Tobias B. Huber, Manfred Jung, Alexander-Thomas Hauser, Wolfgang Sippl, Oliver Kretz, Saskia Lindner, Nicola Wanner, Clemens D. Cohen, Clemens Höse
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4157, p 4157 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 8
International Journal of Molecular Sciences
Volume 22
Issue 8
A growing body of evidence suggests that low nephron numbers at birth can increase the risk of chronic kidney disease or hypertension later in life. Environmental stressors, such as maternal malnutrition, medication and smoking, can influence renal s
Autor:
Guilherme Oliveira, Hugo R. Vaca, Federico Camicia, María Celina Elissondo, Ana M. Celentano, Wolfgang Sippl, Tino Heimburg, Manfred Jung, Ehab Ghazy, Patrik Zeyen, María Agustina Toscanini, Alexander-Thomas Hauser, Mara Cecilia Rosenzvit
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009226 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009226 (2021)
Background Echinococcosis and cysticercosis are neglected tropical diseases caused by cestode parasites (family Taeniidae). Not only there is a small number of approved anthelmintics for the treatment of these cestodiases, but also some of them are n
Publikováno v:
Current opinion in chemical biology. 45
DNA and histone methylation belong to the key regulatory components in the epigenetic machinery, and dysregulations of these processes have been associated with various human diseases. Small molecule modulators of these epigenetic targets are highly