Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Alexander-Francisco Bruns"'
Autor:
Catherine Rucker-Martin, Justin F. X. Ainscough, Baptiste Rode, Philippe Mateo, Florence Lefebvre, Jessica Sabourin, Hollie L. Appleby, Richard Foster, Kaveen Bedouet, Susana Gomez, Jian Shi, Alexander-Francisco Bruns, Fabrice Antigny, Jean-Pierre Benitah, Marc A. Bailey, Rajendra Gosain, Heba Shawer, Fiona Bartoli, Pascale Gerbaud, Richard S. Young, Marjolaine Debant, Jeffrey Plante, A.M. Gomez, Mark T. Kearney, Katherine Norman, David J. Beech
Publikováno v:
Circulation
Supplemental Digital Content is available in the text.
Background: Orai1 is a critical ion channel subunit, best recognized as a mediator of store-operated Ca2+ entry (SOCE) in nonexcitable cells. SOCE has recently emerged as a key contributor o
Background: Orai1 is a critical ion channel subunit, best recognized as a mediator of store-operated Ca2+ entry (SOCE) in nonexcitable cells. SOCE has recently emerged as a key contributor o
Autor:
Georgette Tanner, Martina A Finetti, Steven Pollock, Nora Rippaus, Alexander-Francisco Bruns, Catherine Hogg, Alastair Droop, Anke Bruning-Richardson, Mathew Care, Joseph Wilkinson, Michael Jenkinson, Andrew Brodbelt, Aruna Chakrabarty, Azzam Ismail, Susan Short, Lucy Stead
Publikováno v:
Neuro-Oncology. 24:iv1-iv1
AIMS Glioblastoma (GBM) is the most common primary malignant brain tumour in adults. Despite aggressive treatment, a resistant tumour recurs in practically all patients. We therefore aimed to better understand the mechanisms driving this treatment re
Autor:
Lucy F. Stead, Michael D. Jenkinson, J Manning, Susan C Short, Andrew Brodbelt, Matthew A. Care, Aruna Chakrabarty, M Al-Jabri, Alexander-Francisco Bruns, Alastair Droop, Azzam Ismail, Nora Rippaus
Publikováno v:
Neuro Oncol
BACKGROUND Glioblastoma (GBM) tumours recur following standard treatment in almost all cases. We use ‘omics technologies to simultaneously profile pairs of primary and matched recurrent GBM to specifically identify and characterise the cells that r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ea6825e971b705d08bb8a537479c20
https://eprints.whiterose.ac.uk/162286/1/Rippaus_EANO2019abstract.docx
https://eprints.whiterose.ac.uk/162286/1/Rippaus_EANO2019abstract.docx
Autor:
Pooja Shah, Stephen B. Wheatcroft, Jessica Smith, Alexander-Francisco Bruns, Nadira Yuldasheva, Mark T. Kearney
Publikováno v:
Basic Science.
Introduction The insulin-like growth factor binding protein 2 (IGFBP2) has been implicated in the regulation of insulin-like growth factor 1 (IGF1) activity in most tissue and organs. IGFBP2 has, however, also been reported to have additional intrins
Publikováno v:
Basic Science.
Introduction Insulin like growth factor binding proteins(IGFBP) have cellular effects extending far beyond binding and transport of insulin like growth factors(IGF). Our group showed that global overexpression of IGFBP1 in mice increased insulin sens
Autor:
Alexander-Francisco Bruns, Azzam Ismail, Ruth Morton, Aruna Chakrabarty, Heiko Wurdak, Nora Rippaus, Claire Taylor, Susan C Short, Lucy F. Stead
Publikováno v:
Neuro-Oncology. 20:i22-i22
Glioblastoma (GBM) brain tumours are notoriously heterogeneous, constituting numerous subpopulations of cells with distinct genotypes and/or phenotypes. This level of heterogeneity is likely to facilitate Darwinian selection of treatment-resistant su
Autor:
Alexander-Francisco Bruns, Claudia Grothe, Julia Jungnickel, Peter Claus, Jeroen van Bergeijk, Anna Nölle, Christina Lorbeer
Publikováno v:
Proceedings of the National Academy of Sciences. 106:12747-12752
Nuclear bodies are distinct subnuclear structures. The survival of motoneuron (SMN) gene is mutated or deleted in patients with the neurodegenerative disease spinal muscular atrophy (SMA). The gene product SMN is a marker protein for one class of nuc
Autor:
Stephen B. Wheatcroft, Alexander-Francisco Bruns, Mark T. Kearney, Jessica Smith, Nadira Yuldasheva
Publikováno v:
Heart. 103:A121.1-A121
Introduction The insulin-like growth factor binding protein 2 (IGFBP2) has been implicated in the regulation of insulin-like growth factor (IGF) activity in most tissue and organs. IGFBP2 has, however, been reported to have additional intrinsic, IGF
Autor:
Khaja Syed, Lucy F. Stead, Susan C Short, Katherine M. Ashton, Ruth Morton, Azzam Ismail, Aruna Chakrabarty, S. Harrison, Alexander-Francisco Bruns, Henry King
Publikováno v:
Neuro-Oncology. 18:iv50-iv50
Primary glioblastoma (GBM) tumours recur following treatment. This is likely due to selection and expansion of treatment resistant cells during therapy. Details of the patterns of therapy-driven genomic evolution of these tumours are emerging, but le
The SMN (survival of motoneuron) protein is mutated in patients with the neurodegenerative disease spinal muscular atrophy. We have shown previously that a high-molecular-mass isoform of FGF (fibroblast growth factor) 2 (FGF-223) is in a complex with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af4e56d747319b71e20d749046bed80
https://europepmc.org/articles/PMC1134141/
https://europepmc.org/articles/PMC1134141/