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pro vyhledávání: '"Alexander Y. Tsygankov"'
Autor:
Alexander Y. Tsygankov
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4434 (2024)
This Special Issue entitled “Role of Tula-Family Proteins in Cell Signaling and Activation: Advances and Challenges” is focused on a relatively novel vertebrate gene/protein family termed alternatively TULA, UBASH3, or STS [...]
Externí odkaz:
https://doaj.org/article/5aee6ec6449e4f34a179f0077c4ef99b
Autor:
Pankaj Kumar Singh, Carol A. Dangelmaier, Hymavathi Reddy Vari, Alexander Y. Tsygankov, Satya P. Kunapuli
Publikováno v:
Platelets, Vol 34, Iss 1 (2023)
Alternate splicing is among the regulatory mechanisms imparting functional diversity in proteins. Studying protein isoforms generated through alternative splicing is therefore critical for understanding protein functions in many biological systems. S
Externí odkaz:
https://doaj.org/article/59a190ce04fa438db5cc20248019132a
Autor:
Alexander Y. Tsygankov
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9126 (2023)
The two members of the UBASH3/STS/TULA protein family have been shown to critically regulate key biological functions, including immunity and hemostasis, in mammalian biological systems. Negative regulation of signaling through immune receptor tyrosi
Externí odkaz:
https://doaj.org/article/2b115646c93e45e6946bfbc213275742
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 14910 (2022)
The two members of the UBASH3/TULA/STS-protein family have been shown to critically regulate cellular processes in multiple biological systems. The regulatory function of TULA-2 (also known as UBASH3B or STS-1) in platelets is one of the best example
Externí odkaz:
https://doaj.org/article/33c4be4f58234fba978c77f917851f52
Autor:
John C. Kostyak, Benjamin R. Mauri, Carol Dangelmaier, Akruti Patel, Yuhang Zhou, Johannes A. Eble, Alexander Y. Tsygankov, Steven E. McKenzie, Satya P. Kunapuli
Publikováno v:
TH Open, Vol 02, Iss 04, Pp e411-e419 (2018)
Platelet activation is essential for hemostasis. Central to platelet activation are the signals transmitted through surface receptors such as glycoprotein VI, the protease-activated receptors, and C-type lectin-like receptor 2 (CLEC-2). CLEC-2 is a H
Externí odkaz:
https://doaj.org/article/eba57c87555643969e2802ebd988c4e3
Autor:
Amrita Sarkar, Sanket K. Shukla, Aseel Alqatawni, Anil Kumar, Sankar Addya, Alexander Y. Tsygankov, Khadija Rafiq
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 5 (2018)
Diabetes mellitus (DM) often causes chronic inflammation, hypertrophy, apoptosis and fibrosis in the heart and subsequently leads to myocardial remodeling, deteriorated cardiac function and heart failure. However, the etiology of the cardiac disease
Externí odkaz:
https://doaj.org/article/f1cc37dbdb5e497886d9d6254a657b61
Publikováno v:
Journal of Leukocyte Biology. 110:141-153
Sepsis is a complex clinical condition resulting from a serious bloodstream infection. With mortality rates as high as 50%, improved treatments are needed. Regulatory T cells (Tregs), a subset of T lymphocytes, promote the resolution of inflammation.
Autor:
John C, Kostyak, Benjamin, Mauri, Carol, Dangelmaier, Hymavathi Reddy, Vari, Akruti, Patel, Monica, Wright, Haritha, Reddy, Alexander Y, Tsygankov, Satya P, Kunapuli
Publikováno v:
Journal of Biological Chemistry. 298:102189
Immune cells express receptors bearing an immune tyrosine activation motif (ITAM) containing two YXXL motifs or hemITAMs containing only one YXXL motif. Phosphorylation of the ITAM/hemITAM is mediated by Src family kinases allowing for the binding an
Publikováno v:
Journal of leukocyte biologyREFERENCES. 110(1)
Sepsis is a complex clinical condition resulting from a serious bloodstream infection. With mortality rates as high as 50%, improved treatments are needed. Regulatory T cells (Tregs), a subset of T lymphocytes, promote the resolution of inflammation.
Publikováno v:
J Biol Chem
Fungal pathogen Candida albicans has a complex cell wall consisting of an outer layer of mannans and an inner layer of β-glucans and chitin. The fungal cell wall is the primary target for antifungals and is recognized by host immune cells. Environme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4937870d2e43a3aff2a0f5a23ff92d6
https://europepmc.org/articles/PMC7380197/
https://europepmc.org/articles/PMC7380197/