Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Alexander Y, Simonov"'
Autor:
Igor B. Levshin, Alexander Y. Simonov, Sergey N. Lavrenov, Alexey A. Panov, Natalia E. Grammatikova, Alexander A. Alexandrov, Eslam S. M. O. Ghazy, Nikita A. Savin, Peter V. Gorelkin, Alexander S. Erofeev, Vladimir I. Polshakov
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 563 (2022)
Novel derivatives of Mycosidine (3,5-substituted thiazolidine-2,4-diones) are synthesized by Knoevenagel condensation and reactions of thiazolidines with chloroformates or halo-acetic acid esters. Furthermore, 5-Arylidene-2,4-thiazolidinediones and t
Externí odkaz:
https://doaj.org/article/2f7f303cc2264d6282e8aece6f627613
Autor:
Alexey S. Trenin, Elena B. Isakova, Michael I. Treshchalin, Vasilisa A. Polozkova, Elena P. Mirchink, Alexey A. Panov, Alexander Y. Simonov, Olga P. Bychkova, Victor V. Tatarskiy, Sergey N. Lavrenov
Publikováno v:
Pharmaceuticals, Vol 15, Iss 2, p 118 (2022)
The antimicrobial activity and toxicity of three novel synthetic antibacterial agents containing tris(1H-indol-3-yl)methylium fragment were studied in vitro and in vivo. All compounds in vitro revealed high activity (minimal inhibitory concentration
Externí odkaz:
https://doaj.org/article/bca3f521e64443ccbe39cf083d78031c
Autor:
Sergey N. Lavrenov, Elena B. Isakova, Alexey A. Panov, Alexander Y. Simonov, Viktor V. Tatarskiy, Alexey S. Trenin
Publikováno v:
Pharmaceuticals, Vol 13, Iss 12, p 469 (2020)
The wide spread of pathogens resistance requires the development of new antimicrobial agents capable of overcoming drug resistance. The main objective of the study is to elucidate the effect of substitutions in tris(1H-indol-3-yl)methylium derivative
Externí odkaz:
https://doaj.org/article/badb3b80ee774653b183ae99de2d512d
Autor:
Alexey S, Trenin, Elena B, Isakova, Michael I, Treshchalin, Vasilisa A, Polozkova, Elena P, Mirchink, Alexey A, Panov, Alexander Y, Simonov, Olga P, Bychkova, Victor V, Tatarskiy, Sergey N, Lavrenov
Publikováno v:
Pharmaceuticals (Basel, Switzerland). 15(2)
The antimicrobial activity and toxicity of three novel synthetic antibacterial agents containing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e5052a5771738042723ac4c5748b60db
https://pubmed.ncbi.nlm.nih.gov/35215231
https://pubmed.ncbi.nlm.nih.gov/35215231
Autor:
Alexey A. Panov, Eugeny E. Bykov, Alexey S Trenin, S. N. Lavrenov, Alexander Y. Simonov, Alexander M. Korolev
Publikováno v:
MODERN SYNTHETIC METHODOLOGIES FOR CREATING DRUGS AND FUNCTIONAL MATERIALS (MOSM2020): PROCEEDINGS OF THE IV INTERNATIONAL CONFERENCE.
The difference in the reactivity of maleimide derivatives is explained by the method of calculating partial charges on carbon atoms of 3-substituted-4-bromomaleimides, as well as by 3D molecular modeling. The influence of various substituents on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95a70cdb871025ca78d9951047a6bda1
https://doi.org/10.1063/5.0068441
https://doi.org/10.1063/5.0068441
Autor:
Sergey N. Lavrenov, Alexey A. Panov, Alexey S. Trenin, Sergey A. Lakatosh, Alexander Y. Simonov
Publikováno v:
Chemistry of Heterocyclic Compounds. 54:103-113
This review is devoted to methods for the synthesis of 3,4-disubstituted maleimides – compounds that often show pronounced biological activity. We offer classification of synthetic methods, present comparative analysis of various approaches while d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7457dd1a66bae61517b7617c8b51edeb
https://doi.org/10.1007/s10593-018-2240-z
https://doi.org/10.1007/s10593-018-2240-z
Autor:
Sergey N. Lavrenov, Alexander Y. Simonov, Alexey A. Panov, Alexey S Trenin, Elena B. Isakova, Elena P. Mirchink
Publikováno v:
The Journal of Antibiotics. 72:122-124
A series of 3,4-bis(arylthio)maleimides were synthesized and their antimicrobial activity was evaluated against Gram-positive and Gram-negative bacteria, including multidrug resistant (MDR) strains and some fungi. Most compounds turned out to be high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::833a835b8f0efa27266c3bdcec15c92c
https://doi.org/10.1038/s41429-018-0122-3
https://doi.org/10.1038/s41429-018-0122-3
Autor:
Maria N. Preobrazhenskaya, Yury N. Luzikov, Alexander M. Korolev, Evgeny E. Bykov, Alexander Y. Simonov, M. I. Reznikova, Sergey A. Lakatosh
Publikováno v:
Tetrahedron. 70:625-630
15, 16, and 17-Membered lactones based on the bis-3,4(indol-1-yl)maleimide framework were obtained using intramolecular esterification reaction starting from 3-(1-ω-carboxyalkyl-2,3-dihydroindol-1-yl)-4-(1-ω-hydroxyalkyl-2,3-dihydroindol-1-yl)-male
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72739f8a9a84c82a2ad44b04b997da61
https://doi.org/10.1016/j.tet.2013.12.004
https://doi.org/10.1016/j.tet.2013.12.004
Autor:
Yuryi N. Luzikov, Maria N. Preobrazhenskaya, Frank Totzke, Olga B. Bekker, M. I. Reznikova, Sergey A. Lakatosh, Alexander Y. Simonov, S. M. Elizarov, Valery N. Danilenko, Svetlana S. Printsevskaya, Alexander A. Shtil, Christoph Schächtele, Michael H.G. Kubbutat
Publikováno v:
Journal of Medicinal Chemistry. 51:7731-7736
Aminomethylation of 9b,10-dihydro-1H-indolo[1,7:4,5,6]pyrrolo[3,4:2,3][1,4]diazepino-[1,7-a]indole-1,3(2H)-diones or 1H-indolo[1,7:4,5,6]pyrrolo[3,4:2,3][1,4]diazepino[1,7-a]indole-1,3(2H)-diones resulted in dialkylaminomethyl derivatives. Alkylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ffa3e1b341945a338b327f5c308737
https://doi.org/10.1021/jm800758s
https://doi.org/10.1021/jm800758s
Autor:
Alexander M. Korolev, Sergey A. Lakatosh, Evgeny E. Bykov, Maria N. Preobrazhenskaya, Alexander Y. Simonov, Yury N. Luzikov, M. I. Reznikova
Publikováno v:
ChemInform. 45
15, 16, and 17-Membered lactones based on the bis-3,4(indol-1-yl)maleimide framework were obtained using intramolecular esterification reaction starting from 3-(1-ω-carboxyalkyl-2,3-dihydroindol-1-yl)-4-(1-ω-hydroxyalkyl-2,3-dihydroindol-1-yl)-male
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45c62e14696efcf7dc6d325bb93797a8
https://doi.org/10.1002/chin.201424191
https://doi.org/10.1002/chin.201424191