Zobrazeno 1 - 10 of 58 pro vyhledávání: '"Alexander Wurzer"'
1
Akademický článek
Preclinical comparison of [177Lu]Lu-rhPSMA-10.1 and [177Lu]Lu-rhPSMA-10.2 for endoradiotherapy of prostate cancer: biodistribution and dosimetry studies
Autor: Alexander Wurzer, Francesco De Rose, Sebastian Fischer, Markus Schwaiger, Wolfgang Weber, Stephan Nekolla, Hans-Jürgen Wester, Matthias Eiber, Calogero D’Alessandria
Publikováno v: EJNMMI Radiopharmacy and Chemistry, Vol 9, Iss 1, Pp 1-14 (2024)
Abstract Background Radiohybrid PSMA-targeted ligands (rhPSMA) have been introduced as a novel platform for theranostic applications. Among a variety of rhPSMA-ligands developed for radioligand therapy, two stereoisomers [177Lu]Lu-rhPSMA-10.1 and -10
Externí odkaz: https://doaj.org/article/ccf30793e8eb4523920eb4bb36e6f0e6
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2
Akademický článek
Preclinical biodistribution and dosimetry and human biodistribution comparing 18F-rhPSMA-7 and single isomer 18F-rhPSMA-7.3
Autor: Karina Knorr, So Won Oh, Markus Krönke, Alexander Wurzer, Calogero D’Alessandria, Michael Herz, Wolfgang Weber, Hans-Jürgen Wester, Matthias Eiber, Nahid Yusufi, Stephan Nekolla
Publikováno v: EJNMMI Research, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Background Radiohybrid prostate-specific membrane antigen (rhPSMA) ligands such as 18F-rhPSMA-7 are a new class of theranostic agents in clinical development for prostate cancer. We compared preclinical dosimetry and human biodistribution of
Externí odkaz: https://doaj.org/article/6d6f3110cc4240e4a9a58c67269248bc
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3
Akademický článek
Automated synthesis of [18F]Ga-rhPSMA-7/ -7.3: results, quality control and experience from more than 200 routine productions
Autor: Alexander Wurzer, Daniel Di Carlo, Michael Herz, Antonia Richter, Stephanie Robu, Ralf Schirrmacher, Alba Mascarin, Wolfgang Weber, Matthias Eiber, Markus Schwaiger, Hans-Juergen Wester
Publikováno v: EJNMMI Radiopharmacy and Chemistry, Vol 6, Iss 1, Pp 1-15 (2021)
Abstract Introduction The radiohybrid (rh) prostate-specific membrane antigen (PSMA)-targeted ligand [18F]Ga-rhPSMA-7 has previously been clinically assessed and demonstrated promising results for PET-imaging of prostate cancer. The ligand is present
Externí odkaz: https://doaj.org/article/8f0946dcb5d249ac872b366eaca886a9
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4
Akademický článek
Preclinical comparison of four [18F, natGa]rhPSMA-7 isomers: influence of the stereoconfiguration on pharmacokinetics
Autor: Alexander Wurzer, Mara Parzinger, Matthias Konrad, Roswitha Beck, Thomas Günther, Veronika Felber, Stefanie Färber, Daniel Di Carlo, Hans-Jürgen Wester
Publikováno v: EJNMMI Research, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract Introduction Radiohybrid (rh) ligands, a novel class of prostate-specific membrane antigen (PSMA)-targeted radiopharmaceuticals, can be labeled either with [18F]fluorine via isotopic exchange or with radiometals (such as [68Ga]Gallium, [177L
Externí odkaz: https://doaj.org/article/7ac00bd0ff594505bde0da78cf92916d
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5
Akademický článek
Albumin-Mediated Size Exclusion Chromatography: The Apparent Molecular Weight of PSMA Radioligands as Novel Parameter to Estimate Their Blood Clearance Kinetics
Autor: Jan-Philip Kunert, Sebastian Fischer, Alexander Wurzer, Hans-Jürgen Wester
Publikováno v: Pharmaceuticals, Vol 15, Iss 9, p 1161 (2022)
A meticulously adjusted pharmacokinetic profile and especially fine-tuned blood clearance kinetics are key characteristics of therapeutic radiopharmaceuticals. We, therefore, aimed to develop a method that allowed the estimation of blood clearance ki
Externí odkaz: https://doaj.org/article/247c56d7fa3e49c8a3b36aa0bae4380f
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7
Akademický článek
Equilibrium Thermodynamics, Formation, and Dissociation Kinetics of Trivalent Iron and Gallium Complexes of Triazacyclononane-Triphosphinate (TRAP) Chelators: Unraveling the Foundations of Highly Selective Ga-68 Labeling
Autor: Adrienn Vágner, Attila Forgács, Ernő Brücher, Imre Tóth, Alessandro Maiocchi, Alexander Wurzer, Hans-Jürgen Wester, Johannes Notni, Zsolt Baranyai
Publikováno v: Frontiers in Chemistry, Vol 6 (2018)
In order to rationalize the influence of FeIII contamination on labeling with the 68Ga eluted from 68Ge/68Ga-generator, a detailed investigation was carried out on the equilibrium properties, formation and dissociation kinetics of GaIII- and FeIII-co
Externí odkaz: https://doaj.org/article/5c9674f836cd4111a22d3dd7f4c1ec46
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8
Akademický článek
Synthesis of Symmetrical Tetrameric Conjugates of the Radiolanthanide Chelator DOTPI for Application in Endoradiotherapy by Means of Click Chemistry
Autor: Alexander Wurzer, Adrienn Vágner, Dávid Horváth, Flóra Fellegi, Hans-Jürgen Wester, Ferenc K. Kálmán, Johannes Notni
Publikováno v: Frontiers in Chemistry, Vol 6 (2018)
Due to its 4 carbonic acid groups being available for bioconjugation, the cyclen tetraphosphinate chelator DOTPI, 1,4,7,10-tetraazacyclododecane-1,4,7, 10-tetrakis[methylene(2-carboxyethylphosphinic acid)], represents an ideal scaffold for synthesis
Externí odkaz: https://doaj.org/article/01e301c7310b43c084527984964dfba2
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9
Stand der Technik in der Radiopharmazie
Autor: Alexander Wurzer, Stephan G. Nekolla, Calogero D’Alessandria
Publikováno v: Angewandte Nuklearmedizin. 45:167-188
ZusammenfassungDie wachsende Zahl potenzieller Radioisotope und die steigende Nachfrage nach Radiopharmazeutika (RP) für Bildgebung- und Therapiezwecke haben dazu geführt, dass ihre biomedizinische Anwendung im modernen Gesundheitswesen immer mehr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a63af7dcd52e1ece5ca3acb4d788dc1
https://doi.org/10.1055/a-1715-5069
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