ATR is a multifunctional regulator of male mouse meiosis

Autor: Alexander Widger, Shantha K. Mahadevaiah, Julian Lange, Elias ElInati, Jasmin Zohren, Takayuki Hirota, Sarai Pacheco, Andros Maldonado-Linares, Marcello Stanzione, Obah Ojarikre, Valdone Maciulyte, Dirk G. de Rooij, Attila Tóth, Ignasi Roig, Scott Keeney, James M.A. Turner

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

ATR kinase is required for meiosis in non-mammalian model organisms. Here the authors demonstrate, using a tissue-specific knockout approach, that ATR is also essential for male meiosis in mouse, regulating meiotic recombination and synapsis.

Externí odkaz: https://doaj.org/article/b92089ad88aa43c8bc4181f628f431ba

ATR is a multifunctional regulator of male mouse meiosis

Autor: Obah A. Ojarikre, Scott Keeney, Valdone Maciulyte, Julian Lange, Elias ElInati, Sarai Pacheco, Shantha K. Mahadevaiah, Dirk G. de Rooij, Jasmin Zohren, James M. A. Turner, Attila Tóth, Alexander Widger, Takayuki Hirota, Andros Maldonado-Linares, Ignasi Roig, Marcello Stanzione

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature communications, 9(1):2621. Nature Publishing Group
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Nature Communications
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname

Meiotic cells undergo genetic exchange between homologs through programmed DNA double-strand break (DSB) formation, recombination and synapsis. In mice, the DNA damage-regulated phosphatidylinositol-3-kinase-like kinase (PIKK) ATM regulates all of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea900e3e80245aa81690d46662c4a1c8
https://doi.org/10.1038/s41467-018-04850-0

Recombinogenic Conditions Influence Partner Choice in Spontaneous Mitotic Recombination

Autor: Alexander Widger, James D. Cauwood, Anthony L. Johnson, Rita S. Cha

Publikováno v: PLoS Genetics
PLoS Genetics, Vol 9, Iss 11, p e1003931 (2013)

Mammalian common fragile sites are loci of frequent chromosome breakage and putative recombination hotspots. Here, we utilized Replication Slow Zones (RSZs), a budding yeast homolog of the mammalian common fragile sites, to examine recombination acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6badd6b7e4c98a4bb6b9dc662be5c57d
http://europepmc.org/articles/PMC3820797