Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Alexander W. Macharia"'
Autor:
Neema Mturi, Alexander W. Macharia, George Mochamah, Anna Färnert, Thad Howard, Thomas N. Williams, Russell E. Ware, Johnstone Makale, Peter Olupot-Olupot
Publikováno v:
Wellcome Open Research, Vol 7 (2022)
Background: β-thalassemia is rare in sub-Saharan Africa and to our knowledge there has been no case of homozygous β-thalassemia major reported from this region. In a recent cohort study, we identified four β-thalassemia mutations among 83 heterozy
Externí odkaz:
https://doaj.org/article/31bd5b0570a4450ab3b87999f253527b
Autor:
Peter Olupot-Olupot, Charles Engoru, Julius Nteziyaremye, Martin Chebet, Tonny Ssenyondo, Rita Muhindo, Gideon Nyutu, Alexander W. Macharia, Sophie Uyoga, Carolyne M. Ndila, Charles Karamagi, Kathryn Maitland, Thomas N. Williams
Publikováno v:
Malaria Journal, Vol 19, Iss 1, Pp 1-9 (2020)
Abstract Background Few recent descriptions of severe childhood malaria have been published from high-transmission regions. In the current study, the clinical epidemiology of severe malaria in Mbale, Eastern Uganda, is described, where the entomologi
Externí odkaz:
https://doaj.org/article/9f3252d79f774f128fe2f2470e7f4ac3
Autor:
Carolyne M. Ndila, Vysaul Nyirongo, Alexander W. Macharia, Anna E. Jeffreys, Kate Rowlands, Christina Hubbart, George B. J. Busby, Gavin Band, Rosalind M. Harding, Kirk A. Rockett, Thomas N. Williams, MalariaGEN Consortium
Publikováno v:
Wellcome Open Research, Vol 5 (2021)
Background: The -α3.7I-thalassaemia deletion is very common throughout Africa because it protects against malaria. When undertaking studies to investigate human genetic adaptations to malaria or other diseases, it is important to account for any con
Externí odkaz:
https://doaj.org/article/5e9ddcad45ef4396ace7027c4ecdeac9
Autor:
Alexander W. Macharia, George Mochamah, Sophie Uyoga, Carolyne M. Ndila, Gideon Nyutu, Metrine Tendwa, Emily Nyatichi, Johnstone Makale, Russell E. Ware, Thomas N. Williams
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 8, Iss 7, Pp n/a-n/a (2020)
Abstract Background β‐Thalassemia is rare in sub‐Saharan Africa. Previous studies have suggested that it is limited to specific parts of West Africa. Based on hemoglobin A2 (HbA2) concentrations measured by HPLC, we recently speculated that β
Externí odkaz:
https://doaj.org/article/faa2ed36d4a8425ba8cb47ce5e66d21a
Autor:
Alexander W. Macharia, George Mochamah, Johnstone Makale, Thad Howard, Neema Mturi, Peter Olupot-Olupot, Anna Färnert, Russell E. Ware, Thomas N. Williams
Background: β-thalassemia is rare in sub-Saharan Africa and to our knowledge there has been no case of homozygous β-thalassemia major reported from this region. In a recent cohort study, we identified four β-thalassemia mutations among 83 heterozy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b4f65b32b97ecda34d0e277c36cc69
http://hdl.handle.net/10044/1/98336
http://hdl.handle.net/10044/1/98336
Autor:
Silvia N Kariuki, Alexander W Macharia, Johnstone Makale, Wilfred Nyamu, Stephen L Hoffman, Melissa C Kapulu, Philip Bejon, Julian C Rayner, Thomas N Williams, On behalf of for the CHMI-SIKA Study Team
Publikováno v:
eLife, Vol 12 (2023)
Background: The long co-evolution of Homo sapiens and Plasmodium falciparum has resulted in the selection of numerous human genetic variants that confer an advantage against severe malaria and death. One such variant is the Dantu blood group antigen,
Externí odkaz:
https://doaj.org/article/d7bea6c1ed454a08936dbbdec5422d73