Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Alexander W. MacFarlane"'
Autor:
Jason S. Wasserman, Holly Fowle, Rumesa Hashmi, Diba Atar, Kishan R. Patel, Amir Yarmahmoodi, Alexander W. Macfarlane, Yinfei Tan, Edna Cukierman, Bojana Gligorijevic, Adam Karami, Kelly A. Whelan, Kerry S. Campbell, Xavier Graña
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Prostate cancer (PCa) is the most common cancer diagnosed in men worldwide and was the second leading cause of cancer-related deaths in US males in 2022. Prostate cancer also represents the second highest cancer mortality disparity between n
Externí odkaz:
https://doaj.org/article/398f3efd1a784589babef813afa2a8f6
Autor:
Matthew Zibelman, Alexander W. MacFarlane, Kimberly Costello, Thomas McGowan, John O’Neill, Rutika Kokate, Hossein Borghaei, Crystal S. Denlinger, Efrat Dotan, Daniel M. Geynisman, Angela Jain, Lainie Martin, Elias Obeid, Karthik Devarajan, Karen Ruth, R. Katherine Alpaugh, Essel Al-Saleem Dulaimi, Edna Cukierman, Margret Einarson, Kerry S. Campbell, Elizabeth R. Plimack
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract This phase I, dose-escalation trial evaluates the safety of combining interferon-gamma (IFN-γ) and nivolumab in patients with metastatic solid tumors. Twenty-six patients are treated in four cohorts assessing increasing doses of IFN-γ with
Externí odkaz:
https://doaj.org/article/ce3d085e03764e52a9561fa23ca9cb9a
Autor:
Sandra V. Fernandez, Alexander W. MacFarlane, Mowafaq Jillab, Maria F. Arisi, Jennifer Yearley, Lakshmanan Annamalai, Yulan Gong, Kathy Q. Cai, R. Katherine Alpaugh, Massimo Cristofanilli, Kerry S. Campbell
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-16 (2020)
Abstract Background Inflammatory breast cancer (IBC) is a rare but aggressive carcinoma characterized by severe erythema and edema of the breast, with many patients presenting in advanced metastatic disease. The “inflammatory” nature is not due t
Externí odkaz:
https://doaj.org/article/6bbb7ddf9f254fc4a9ff80dea3bff104
Autor:
Jill W. Ford, Marieli Gonzalez-Cotto, Alexander W. MacFarlane, Suraj Peri, O. M. Zack Howard, Jeffrey J. Subleski, Karen J. Ruth, Mohammed Haseebuddin, Tahseen Al-Saleem, Youfeng Yang, Pat Rayman, Brian Rini, W. Marston Linehan, James Finke, Jonathan M. Weiss, Kerry S. Campbell, Daniel W. McVicar
Publikováno v:
Frontiers in Oncology, Vol 11 (2022)
Myeloid-derived suppressor cells (MDSC) and tumor-associated macrophages (TAM) contribute to cancer-related inflammation and tumor progression. While several myeloid molecules have been ascribed a regulatory function in these processes, the triggerin
Externí odkaz:
https://doaj.org/article/b29a1d769f3c4074858d8da7e828b13c
Autor:
Dmitry Zhigarev, Asya Varshavsky, Alexander W. MacFarlane, Prathiba Jayaguru, Laura Barreyro, Marina Khoreva, Essel Dulaimi, Reza Nejati, Christina Drenberg, Kerry S. Campbell
Publikováno v:
Cancers, Vol 14, Iss 14, p 3352 (2022)
Acute myeloid leukemia (AML) is an aggressive malignancy that requires rapid treatment with chemotherapies to reduce tumor burden. However, these chemotherapies can compromise lymphocyte function, thereby hindering normal anti-tumor immune responses
Externí odkaz:
https://doaj.org/article/7b676a45f4a64cd99b171e740f7b66cd
Autor:
Tatiana Pazina, Alexander W. MacFarlane, Luca Bernabei, Essel Dulaimi, Rebecca Kotcher, Clinton Yam, Natalie A. Bezman, Michael D. Robbins, Eric A. Ross, Kerry S. Campbell, Adam D. Cohen
Publikováno v:
Cancers, Vol 13, Iss 2, p 226 (2021)
Accumulating evidence demonstrates important roles for natural killer (NK) cells in controlling multiple myeloma (MM). A prospective flow cytometry-based analysis of NK cells in the blood and bone marrow (BM) of MM patient subgroups was performed (sm
Externí odkaz:
https://doaj.org/article/75c17649fb994e4e897d1070881ddcda
Autor:
Tatiana Pazina, Ashley M. James, Alexander W. MacFarlane, Natalie A. Bezman, Karla A. Henning, Christine Bee, Robert F. Graziano, Michael D. Robbins, Adam D. Cohen, Kerry S. Campbell
Publikováno v:
OncoImmunology, Vol 6, Iss 9 (2017)
Elotuzumab is a humanized therapeutic monoclonal antibody directed to the surface glycoprotein SLAMF7 (CS1, CRACC, CD319), which is highly expressed on multiple myeloma (MM) tumor cells. Improved clinical outcomes have been observed following treatme
Externí odkaz:
https://doaj.org/article/e05a7c7070914bb0ac2df82d3517c889
Autor:
Alexander W. MacFarlane, Mowafaq Jillab, Mitchell R. Smith, R. Katherine Alpaugh, Marion E. Cole, Samuel Litwin, Michael M. Millenson, Tahseen Al-Saleem, Adam D. Cohen, Kerry S. Campbell
Publikováno v:
OncoImmunology, Vol 6, Iss 7 (2017)
A prospective analysis of natural killer (NK) cell phenotype and function was performed on fresh peripheral blood samples from untreated patients with B-cell chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). Compared to healthy
Externí odkaz:
https://doaj.org/article/88a0d9c84d12467e99493b7558fedcd3
Autor:
H. Josh Jang, Galen Hostetter, Alexander W. Macfarlane, Zachary Madaj, Eric A. Ross, Toshinori Hinoue, Justin R. Kulchycki, Ryan S. Burgos, Mahvish Tafseer, R. Katherine Alpaugh, Candice L. Schwebel, Rutika Kokate, Daniel M. Geynisman, Matthew R. Zibelman, Pooja Ghatalia, Peter W. Nichols, Woonbok Chung, Jozef Madzo, Noah M. Hahn, David I. Quinn, Jean-Pierre J. Issa, Michael J. Topper, Stephen B. Baylin, Hui Shen, Kerry S. Campbell, Peter A. Jones, Elizabeth R. Plimack
Publikováno v:
Clinical Cancer Research. 29:2052-2065
Purpose: On the basis of preclinical evidence of epigenetic contribution to sensitivity and resistance to immune checkpoint inhibitors (ICI), we hypothesized that guadecitabine (hypomethylating agent) and atezolizumab [anti–programmed cell death li
Autor:
Elizabeth R. Plimack, Peter A. Jones, Kerry S. Campbell, Hui Shen, Stephen B. Baylin, Michael J. Topper, Jean-Pierre J. Issa, David I. Quinn, Noah M. Hahn, Jozef Madzo, Woonbok Chung, Peter W. Nichols, Pooja Ghatalia, Matthew R. Zibelman, Daniel M. Geynisman, Rutika Kokate, Candice L. Schwebel, R. Katherine Alpaugh, Mahvish Tafseer, Ryan S. Burgos, Justin R. Kulchycki, Toshinori Hinoue, Eric A. Ross, Zachary Madaj, Alexander W. Macfarlane, Galen Hostetter, H. Josh Jang
Supplementary Figure 8: PD-L1 levels in tumor or tumor microenvironment does not associate with tumor progression or control.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e7a8eb8aff8605de7e80f259eb3a7f2
https://doi.org/10.1158/1078-0432.22587042
https://doi.org/10.1158/1078-0432.22587042