Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Alexander W. Gough"'
Autor:
J. F. Reindel, Gregg Sobocinski, Alexander W. Gough, Gary D. Pilcher, Walter F. Bobrowski, Felix A. de la Iglesia
Publikováno v:
Toxicologic Pathology. 29:159-173
Epidermal growth factor (EGF) effects have been explored extensively in vivo in rodents, but little is known about trophic responses in nonhuman primates. A previous publication reports the hyperplastic epithelial/parenchymal changes noted in the dig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1df87bb26da9831425c8da12361becb
https://doi.org/10.1080/019262301317052431
https://doi.org/10.1080/019262301317052431
Autor:
L. A. Dethloff, Alexander W. Gough, Michael J. Graziano, Edwin Goldenthal, Felix A. de la Iglesia
Publikováno v:
Human & Experimental Toxicology. 15:335-348
1 Phenytoin is a hydantoin-type anticonvulsive agent used extensively for nearly sixty years in the prophylactic treatment of grand mal and psychomotor seizures. 2 Based upon somewhat contentious evidence of pheny toin-induced lymphoma in mice and up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361a7d6255bd0fb7961c03f7aced713b
https://doi.org/10.1177/096032719601500410
https://doi.org/10.1177/096032719601500410
Autor:
James Herman, John A. Anderson, Felix A. de la Iglesia, Alexander W. Gough, David G. Pegg, E. J. Mcguire, J.C. Theiss
Publikováno v:
The Journal of Toxicological Sciences. 21:207-214
Acute, subacute, and chronic toxicity studies, carcinogenicity bioassays, and reproductive and genetic toxicology studies were performed with quinapril, an ACE inhibitor used in the treatment of hypertension. Acute toxicity is minimal in rodents, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a8c4a4ab04fbb49c7a8db01e436b39
https://doi.org/10.2131/jts.21.4_207
https://doi.org/10.2131/jts.21.4_207
Toxicologic Effects of a Novel Acyl-CoA: Cholesterol Acyltransferase Inhibitor in Cynomolgus Monkeys
Publikováno v:
Toxicologic Pathology. 22:510-518
PD 132301-2, an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor, was administered orally to cynomolgus monkeys for 2 wk at doses of 25, 50, 100, and 200 mg/kg to assess potential subacute toxicity. Sporadic episodes of soft feces and diarrhea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae1814250a998822afa8140fe7144623
https://doi.org/10.1177/019262339402200505
https://doi.org/10.1177/019262339402200505
Autor:
Felix A. de la Iglesia, Susanne Gorospe, Steven K. Duddy, Robert F. Parker, Alexander W. Gough, Michael R. Bleavins, Paul E. Rowse, L. A. Dethloff
Publikováno v:
Toxicology and applied pharmacology. 156(2)
Hemangiomas and hemangiosarcomas are uncommon in rodents and humans and, as such, the mechanisms giving rise to these tumors are poorly understood. Inactivating mutations in the p53 gene have been detected in sporadic and chemically induced human and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22430a825f5a935575cb6fcb6367c3d6
https://pubmed.ncbi.nlm.nih.gov/10198275
https://pubmed.ncbi.nlm.nih.gov/10198275
Publikováno v:
Toxicology. 98(1-3)
Gabapentin, an anticonvulsant agent designated chemically as 1-(aminomethyl)-cyclohexaneacetic acid, was evaluated in a 2-year tumor bioassay in male Wistar rats. Three groups of 50 rats were fed gabapentin at 250, 1000 and 2000 mg/kg in the diet for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78803e6f67a14d9be4c2d0e40291ed11
https://pubmed.ncbi.nlm.nih.gov/7740556
https://pubmed.ncbi.nlm.nih.gov/7740556
Publikováno v:
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 46(4-5)
Amsacrine is an aminoacridine that binds to DNA by intercalation. Because amsacrine interferes with DNA synthesis it has potent genotoxic and cytotoxic properties. To define its tumorigenic nature, amsacrine was studied in a 104-week carcinogenicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ab868a8fc4714ec48051606959d72c7
https://pubmed.ncbi.nlm.nih.gov/7894236
https://pubmed.ncbi.nlm.nih.gov/7894236
Publikováno v:
Environmental Health Perspectives. 105:903
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c6d836b6986686636342bd1501f3739
https://doi.org/10.2307/3433863
https://doi.org/10.2307/3433863
Publikováno v:
Toxicologic Pathology. 12:26-38
A morphologic study of spontaneous proliferative lesions of the mammary gland was based on histologic examination of mammary glands from 1020 male and 1145 female albino Wistar rats aged 6 to 110 weeks. Three hundred and seventy-five mammary tumors r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab54e3c65ac6d29f1ebe6735e0965c2
https://doi.org/10.1177/019262338401200104
https://doi.org/10.1177/019262338401200104
Autor:
N. J. Barsoum, Lorelie Mitchell, Felix A. de la Iglesia, Alexander W. Gough, Edward J. McGuire
Publikováno v:
Toxicology and applied pharmacology. 51(1)
Oxolinic acid and pipemidic acid were administered orally to young beagle dogs for 14 days. Dogs receiving oxolinic acid were hyperactive throughout the study and showed transient hindlimb stiffness on Day 12. In contrast, dogs treated with pipemidic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::892b6685a9ac24e4d6957f15255e17ab
https://pubmed.ncbi.nlm.nih.gov/524369
https://pubmed.ncbi.nlm.nih.gov/524369