Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Alexander W. Fischer"'
Autor:
Susanna Canali, Alexander W. Fischer, Mychael Nguyen, Karl Anderson, Lorna Wu, Anne-Renee Graham, Chiaowen Joyce Hsiao, Chinmayi Bankar, Nancy Dussault, Veronica Ritchie, Meagan Goodridge, Todd Sparrow, Allison Pannoni, Sze-Wah Tse, Vivienne Woo, Kaitlin Klovdahl, Jared Iacovelli, Eric Huang
Publikováno v:
Molecular Metabolism, Vol 86, Iss , Pp 101965- (2024)
Objective: Interleukin (IL)-22 is a potential therapeutic protein for the treatment of metabolic diseases such as obesity, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease due to its involvement in multiple cellular pathw
Externí odkaz:
https://doaj.org/article/1607d00e88f946c5834284e04933fa31
Autor:
Anna Worthmann, Julius Ridder, Sharlaine Y. L. Piel, Ioannis Evangelakos, Melina Musfeldt, Hannah Voß, Marie O’Farrell, Alexander W. Fischer, Sangeeta Adak, Monica Sundd, Hasibullah Siffeti, Friederike Haumann, Katja Kloth, Tatjana Bierhals, Markus Heine, Paul Pertzborn, Mira Pauly, Julia-Josefine Scholz, Suman Kundu, Marceline M. Fuh, Axel Neu, Klaus Tödter, Maja Hempel, Uwe Knippschild, Clay F. Semenkovich, Hartmut Schlüter, Joerg Heeren, Ludger Scheja, Christian Kubisch, Christian Schlein
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Dietary polyunsaturated fatty acids (PUFA) are increasingly recognized for their health benefits, whereas a high production of endogenous fatty acids – a process called de novo lipogenesis (DNL) - is closely linked to metabolic diseases. D
Externí odkaz:
https://doaj.org/article/d4a6b8efd8424ceaa3b39a71f53879ef
Publikováno v:
Adipocyte, Vol 11, Iss 1, Pp 28-33 (2022)
Oxidative tissues such as brown adipose tissue and muscle internalize large amounts of circulating lipids and glucose as energy source. Endothelial cells (ECs) provide a platform for regulated transport and processing of blood-borne nutrients. Next t
Externí odkaz:
https://doaj.org/article/c3b1b677bfdf4ba08bf0289a599bd288
Autor:
Sebastian Boland, Sharan Swarup, Yohannes A. Ambaw, Pedro C. Malia, Ruth C. Richards, Alexander W. Fischer, Shubham Singh, Geetika Aggarwal, Salvatore Spina, Alissa L. Nana, Lea T. Grinberg, William W. Seeley, Michal A. Surma, Christian Klose, Joao A. Paulo, Andrew D. Nguyen, J. Wade Harper, Tobias C. Walther, Robert V. Farese
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Progranulin-deficieny results in gangliosidosis due to reduced lysosomal lipids (BMP) required for ganglioside degradation. Lysosomal ganglioside accumulation may contribute to neuroinflammation and neurodegeneration susceptibility observed in FTD.
Externí odkaz:
https://doaj.org/article/1474593e97d94a4ab73bc2bde059f30e
Autor:
Alexander W. Fischer, Janina Behrens, Frederike Sass, Christian Schlein, Markus Heine, Paul Pertzborn, Ludger Scheja, Joerg Heeren
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 11, Pp 1377-1389 (2020)
Adaptive thermogenesis is highly dependent on uncoupling protein 1 (UCP1), a protein expressed by thermogenic adipocytes present in brown adipose tissue (BAT) and white adipose tissue (WAT). Thermogenic capacity of human and mouse BAT can be measured
Externí odkaz:
https://doaj.org/article/1d35fad949ca4d33ae41051241cad7c3
Autor:
Imke Liebold, Simon Meyer, Markus Heine, Anastasia Kuhl, Jennifer Witt, Leah Eissing, Alexander W. Fischer, Anja Christina Koop, Johannes Kluwe, Julian Schulze zur Wiesch, Malte Wehmeyer, Uwe Knippschild, Ludger Scheja, Joerg Heeren, Lidia Bosurgi, Anna Worthmann
Publikováno v:
Cells, Vol 12, Iss 3, p 341 (2023)
Nonalcoholic fatty liver disease (NAFLD) is the most common liver pathology worldwide. In mice and humans, NAFLD progression is characterized by the appearance of TREM2-expressing macrophages in the liver. However, their mechanistic contributions to
Externí odkaz:
https://doaj.org/article/06133a66adc2417b97bb966c22540fd2
Role of Liver CD38 in the Regulation of Metabolic Pathways during Cold-Induced Thermogenesis in Mice
Autor:
Andrea Benzi, Sonia Spinelli, Laura Sturla, Markus Heine, Alexander W. Fischer, Friedrich Koch-Nolte, Hans-Willi Mittrücker, Andreas H. Guse, Antonio De Flora, Joerg Heeren, Santina Bruzzone
Publikováno v:
Cells, Vol 11, Iss 23, p 3812 (2022)
Boosting NAD+ levels are considered a promising means to promote healthy aging and ameliorate dysfunctional metabolism. The expression of CD38, the major NAD+-consuming enzyme, is downregulated during thermogenesis in both brown and white adipose tis
Externí odkaz:
https://doaj.org/article/2bbe202a521248858605b5a7300a8e0b
Autor:
Frederike Sass, Christian Schlein, Michelle Y. Jaeckstein, Paul Pertzborn, Michaela Schweizer, Thorsten Schinke, Andrea Ballabio, Ludger Scheja, Joerg Heeren, Alexander W. Fischer
Publikováno v:
Molecular Metabolism, Vol 47, Iss , Pp 101173- (2021)
Objective: Brown adipose tissue (BAT) thermogenesis offers the potential to improve metabolic health in mice and humans. However, humans predominantly live under thermoneutral conditions, leading to BAT whitening, a reduction in BAT mitochondrial con
Externí odkaz:
https://doaj.org/article/61c0ca3b350b405cbd5fff8238e7249a
Autor:
Christian Schlein, Alexander W. Fischer, Frederike Sass, Anna Worthmann, Klaus Tödter, Michelle Y. Jaeckstein, Janina Behrens, Matthew D. Lynes, Michael A. Kiebish, Niven R. Narain, Val Bussberg, Abena Darkwah, Naja Zenius Jespersen, Søren Nielsen, Camilla Scheele, Michaela Schweizer, Ingke Braren, Alexander Bartelt, Yu-Hua Tseng, Joerg Heeren, Ludger Scheja
Publikováno v:
Cell Reports, Vol 34, Iss 2, Pp 108624- (2021)
Summary: Thermoneutral conditions typical for standard human living environments result in brown adipose tissue (BAT) involution, characterized by decreased mitochondrial mass and increased lipid deposition. Low BAT activity is associated with poor m
Externí odkaz:
https://doaj.org/article/8ed0fd3d09e243ad800cc875dc39ea85
Publikováno v:
Cell Reports, Vol 33, Iss 5, Pp 108348- (2020)
Summary: Brown adipocytes store metabolic energy as triglycerides (TGs) in lipid droplets (LDs). Fatty acids released from brown adipocyte LDs by lipolysis are thought to activate and fuel UCP1-mediated thermogenesis. Here, we test this hypothesis by
Externí odkaz:
https://doaj.org/article/0b313c34c0ba4ccdb5f8476de02edd2f