Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Alexander W. Bruce"'
Autor:
Sterlin T. Raj, Alexander W. Bruce, Muralidharan Anbalagan, Hemalatha Srinivasan, Sasikala Chinnappan, Mogana Rajagopal, Kushagra Khanna, Harish C. Chandramoorthy, Ravishankar Ram Mani
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
The novel coronavirus disease 2019 (COVID-19) pandemic outbreak caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has garnered unprecedented global attention. It caused over 2.47 million deaths through various syndromes such as a
Externí odkaz:
https://doaj.org/article/86df2832f1924b5ba8686ae858665b94
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Assisted Reproductive Technologies (ART) have revolutionized infertility treatment and animal breeding, but their success largely depends on selecting high-quality oocytes for fertilization and embryos for transfer. During preimplantation development
Externí odkaz:
https://doaj.org/article/36ba558e7f2a468994e66994ccbe363a
Autor:
Lenka Gahurova, Jana Tomankova, Pavlina Cerna, Pablo Bora, Michaela Kubickova, Giorgio Virnicchi, Kristina Kovacovicova, David Potesil, Pavel Hruska, Zbynek Zdrahal, Martin Anger, Andrej Susor, Alexander W. Bruce
Publikováno v:
Open Biology, Vol 13, Iss 8 (2023)
Preimplantation mouse embryo development involves temporal–spatial specification and segregation of three blastocyst cell lineages: trophectoderm, primitive endoderm and epiblast. Spatial separation of the outer-trophectoderm lineage from the two o
Externí odkaz:
https://doaj.org/article/1297ef37d6e343db8ca19d9d4317e37b
Autor:
Pablo Bora, Lenka Gahurova, Tomáš Mašek, Andrea Hauserova, David Potěšil, Denisa Jansova, Andrej Susor, Zbyněk Zdráhal, Anna Ajduk, Martin Pospíšek, Alexander W. Bruce
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-19 (2021)
Bora et al. show that an early blastocyst window of p38-MAPK activity regulates ribosome-related gene expression, rRNA precursor processing, polysome formation, and protein translation. This study suggests a distinct role of p38-MAPKs for providing a
Externí odkaz:
https://doaj.org/article/2d718886001a4b338d26b0dc2ade0e25
Autor:
Pablo Bora, Lenka Gahurova, Andrea Hauserova, Martina Stiborova, Rebecca Collier, David Potěšil, Zbyněk Zdráhal, Alexander W. Bruce
Publikováno v:
Open Biology, Vol 11, Iss 7 (2021)
Successful navigation of the mouse preimplantation stages of development, during which three distinct blastocyst lineages are derived, represents a prerequisite for continued development. We previously identified a role for p38-mitogen-activated kina
Externí odkaz:
https://doaj.org/article/8f8d9742250e4edf97faf2b4b64916ec
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Formation of the hatching mouse blastocyst marks the end of preimplantation development, whereby previous cell cleavages culminate in the formation of three distinct cell lineages (trophectoderm, primitive endoderm and epiblast). We report that dysre
Externí odkaz:
https://doaj.org/article/83be498610024f11b1cf9da8fc44ae2b
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Maternal starvation coincident with preimplantation development has profound consequences for placental-fetal development, with various identified pathologies persisting/manifest in adulthood; the ‘Developmental Origin of Health and Disease’ (DOH
Externí odkaz:
https://doaj.org/article/a56ac91ddd114b51b46a6fd86d6c34bb
Autor:
Tomas Masek, Edgar del Llano, Lenka Gahurova, Michal Kubelka, Andrej Susor, Kristina Roucova, Chih-Jen Lin, Alexander W. Bruce, Martin Pospisek
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 4, p 1254 (2020)
Meiotic maturation of oocyte relies on pre-synthesised maternal mRNA, the translation of which is highly coordinated in space and time. Here, we provide a detailed polysome profiling protocol that demonstrates a combination of the sucrose gradient ul
Externí odkaz:
https://doaj.org/article/7a9be4c9d3404b0587f28699534b2398
Publikováno v:
Open Biology, Vol 7, Iss 11 (2017)
During the first cell-fate decision of mouse preimplantation embryo development, a population of outer-residing polar cells is segregated from a second population of inner apolar cells to form two distinct cell lineages: the trophectoderm and the inn
Externí odkaz:
https://doaj.org/article/c71eac727d804369a4b1dc334738cd84
Autor:
Vasanth Thamodaran, Alexander W. Bruce
Publikováno v:
Open Biology, Vol 6, Iss 9 (2016)
During mouse preimplantation embryo development, the classically described second cell-fate decision involves the specification and segregation, in blastocyst inner cell mass (ICM), of primitive endoderm (PrE) from pluripotent epiblast (EPI). The act
Externí odkaz:
https://doaj.org/article/92f55d515db646a8b3fc2893d021698d